PMID- 32835969 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20201221 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 263 DP - 2021 Jan TI - Prenatal exposure to multiple phenolic compounds, fetal reproductive hormones, and the second to fourth digit ratio of children aged 10 years in a prospective birth cohort. PG - 127877 LID - S0045-6535(20)32072-5 [pii] LID - 10.1016/j.chemosphere.2020.127877 [doi] AB - Select phenols are known to possess hormone-disrupting properties, but no previous study has addressed the potential effects of prenatal exposure to phenol mixtures on fetal reproductive hormones and children's second to fourth digit (2D: 4D) ratio, a marker for in utero testosterone (T) exposure. We aimed to explore interrelations of prenatal phenol exposures individually and in mixtures, cord serum reproductive hormones, and 2D: 4D ratio of children aged 10 years. Urinary 11 phenol concentrations were determined from 392 pregnant women participating in a longitudinal birth cohort. We estimated associations of prenatal phenol exposures individually and in mixtures with cord reproductive hormones and children's 2D:4D ratio using three statistical approaches, including generalized linear models (GLMs), elastic net regression (ENR) models and Bayesian kernel machine regression (BKMR) models. In female newborns, the three models showed that maternal triclosan (TCS) concentrations were significantly negatively associated with cord serum T levels [regression coefficient (beta) = -0.076, 95% confidence interval (CI): 0.138, -0.013; p = 0.018]. Additionally, maternal urinary bisphenol A (BPA) levels were related to decreases in 2D:4D ratio of the left hand in girls by GLMs (beta = -0.003, 95% CI: 0.007, -0.001; p = 0.024) and ENR models, but not BKMR models. We provided evidence that prenatal TCS exposure predicted lower cord serum T levels, and maternal BPA exposure was related to decreased 2D:4D ratio of the left hand in females. CI - Copyright (c) 2020 Elsevier Ltd. All rights reserved. FAU - Guo, Jianqiu AU - Guo J AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Wu, Chunhua AU - Wu C AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: chwu@shmu.edu.cn. FAU - Zhang, Jiming AU - Zhang J AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Li, Wenting AU - Li W AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Lv, Shenliang AU - Lv S AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Lu, Dasheng AU - Lu D AD - Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China. FAU - Qi, Xiaojuan AU - Qi X AD - Zhejiang Provincial Center for Disease Control and Prevention, No. 3399 Binsheng Road, Hangzhou, 310051, China. FAU - Feng, Chao AU - Feng C AD - Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China. FAU - Liang, Weijiu AU - Liang W AD - Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, 200051, China. FAU - Chang, Xiuli AU - Chang X AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Zhang, Yubin AU - Zhang Y AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. FAU - Xu, Hao AU - Xu H AD - Changning District Center for Disease Control and Prevention, No.39 Yunwushan Road, Shanghai, 200051, China. FAU - Cao, Yang AU - Cao Y AD - Clinical Epidemiology and Biostatistics, School of Medical Sciences, Orebro University, Orebro, 70182, Sweden. FAU - Wang, Guoquan AU - Wang G AD - Shanghai Municipal Center for Disease Control and Prevention, No. 1380 Zhongshan West Road, Shanghai, 200336, China. FAU - Zhou, Zhijun AU - Zhou Z AD - School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education/Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China. Electronic address: zjzhou@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20200809 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Phenols) SB - IM MH - Aged MH - Bayes Theorem MH - Child MH - Female MH - Humans MH - Infant, Newborn MH - Maternal Exposure MH - Phenols/toxicity MH - Pregnancy MH - *Prenatal Exposure Delayed Effects MH - Prospective Studies OTO - NOTNLM OT - Bayesian kernel machine regression OT - Elastic net regression OT - Phenol mixtures OT - Reproductive hormones OT - The second to fourth digit ratio COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/08/25 06:00 MHDA- 2020/12/22 06:00 CRDT- 2020/08/25 06:00 PHST- 2020/05/28 00:00 [received] PHST- 2020/07/25 00:00 [revised] PHST- 2020/07/29 00:00 [accepted] PHST- 2020/08/25 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] PHST- 2020/08/25 06:00 [entrez] AID - S0045-6535(20)32072-5 [pii] AID - 10.1016/j.chemosphere.2020.127877 [doi] PST - ppublish SO - Chemosphere. 2021 Jan;263:127877. doi: 10.1016/j.chemosphere.2020.127877. Epub 2020 Aug 9.