PMID- 32839556
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20220716
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 35
IP  - 6
DP  - 2021 Jun
TI  - Indocyanine green angiographic findings in presumed intraocular tuberculosis.
PG  - 1680-1687
LID - 10.1038/s41433-020-01144-y [doi]
AB  - PURPOSE: To study features of Indocyanine green angiography (ICGA) in patients 
      with presumed intraocular tuberculosis. METHODS: Retrospective study of 48 
      consecutive patients (77 eyes) who underwent ICGA. The following signs were 
      analysed: choroidal perfusion inhomogeneity, early hyperfluorescent stromal 
      vessels, round or oval hypofluorescent dark dots (HDDs), hypofluorescent 
      geographic lesions (HGLs), fuzzy or lost pattern of large stromal choroidal 
      vessels, disc hyperfluorescence and diffuse late choroidal hyperfluorescence. 
      RESULTS: Among 44 eyes of 29 patients with no clinical evidence of choroidal 
      involvement, only 7 eyes of 6 patients had no ICGA evidence of choroidal 
      involvement. On the other hand, ICGA findings suggesting choroidal involvement 
      were noted in 37 (84.1%) eyes of 23 patients in the form of HDDs in all 37 (100%) 
      eyes, HGLs in 7 (18.9%) eyes, disc hyperfluorescence in 20 (45.5%) eyes, fuzzy 
      stromal vessels in 17 (38.6%) eyes, early hyperfluorescent stromal vessels in 13 
      (29.5%) eyes, late pinpoint hyperfluorescence in 11 (25%) eyes and late diffuse 
      choroidal hyperfluorescence in 7 (15.9%) eyes. Among 33 eyes of 19 patients with 
      clinically evident choroidal involvement, the following findings were identified; 
      HDDs in 12 (36.4%) eyes, HGLs in 10 (30.3%) eyes, both HDDs and HGLs in 9 (27.3%) 
      eyes, disc hyperfluorescence in 11 (33.3%) eyes, early hyperfluorescent stromal 
      vessels in 7 (21.2%) eyes, fuzzy stromal vessels in 6 (18.2%) eyes and late 
      diffuse choroidal hyperfluorescence was present in 2 (6.1%) eyes. CONCLUSIONS: 
      ICGA is necessary in identifying and diagnosing subclinical tuberculous choroidal 
      involvement. The most prevalent ICGA finding was persistent HDDs.
FAU - Abouammoh, Marwan A
AU  - Abouammoh MA
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - De Simone, Luca
AU  - De Simone L
AD  - Ocular Immunology Unit, Azienda USL-IRCCS, Reggio Emilia, Italy.
FAU - Almousa, Abdullah N
AU  - Almousa AN
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Al-Dossari, Mona
AU  - Al-Dossari M
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia.
FAU - Herbort, Carl P
AU  - Herbort CP
AD  - Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care 
      (COS), Clinic Montchoisi Teaching Centre, and Department of Ophthalmology, 
      University of Lausanne, Lausanne, Switzerland.
FAU - Abu El-Asrar, Ahmed M
AU  - Abu El-Asrar AM
AD  - Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, 
      Saudi Arabia. abuelasrar@yahoo.com.
AD  - Dr. Nasser Al-Rashid Research Chair in Ophthalmology, King Saud University, 
      Riyadh, Saudi Arabia. abuelasrar@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20200824
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Choroid
MH  - Coloring Agents
MH  - Fluorescein Angiography
MH  - Humans
MH  - *Indocyanine Green
MH  - Retrospective Studies
MH  - *Tuberculosis
PMC - PMC8169866
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/08/26 06:00
MHDA- 2021/07/01 06:00
PMCR- 2022/06/01
CRDT- 2020/08/26 06:00
PHST- 2020/03/28 00:00 [received]
PHST- 2020/08/12 00:00 [accepted]
PHST- 2020/07/14 00:00 [revised]
PHST- 2020/08/26 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2020/08/26 06:00 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - 10.1038/s41433-020-01144-y [pii]
AID - 1144 [pii]
AID - 10.1038/s41433-020-01144-y [doi]
PST - ppublish
SO  - Eye (Lond). 2021 Jun;35(6):1680-1687. doi: 10.1038/s41433-020-01144-y. Epub 2020 
      Aug 24.