PMID- 32841297
OWN - NLM
STAT- MEDLINE
DCOM- 20201019
LR  - 20201019
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 8
DP  - 2020
TI  - Association of sleep duration and quality with elevated hs-CRP among healthy 
      Korean adults.
PG  - e0238053
LID - 10.1371/journal.pone.0238053 [doi]
LID - e0238053
AB  - This study aimed to investigate the association of sleep duration and quality 
      with high-sensitivity C-reactive protein (hs-CRP) among middle-aged and elderly 
      Koreans. Among a total of 74,867 participants (25,069 men and 49,798 women) 
      recruited for the Health Examinees (HEXA) study, adjusted geometric means of 
      hs-CRP level were compared across categories of sleep duration (<6, 6-7, 8-9, and 
      >/=10 hours) and sleep quality (difficulty in initiating sleep and maintaining 
      sleep) using ANCOVA models. Odds ratios (ORs) and 95% confidence intervals (CIs) 
      for elevated hs-CRP (>3 mg/L) associated with sleep characteristics were 
      estimated using multivariable-adjusted logistic regression models. Men who slept 
      >/=10 hours per day were significantly associated with elevated hs-CRP (OR = 1.47, 
      95% CI 1.11-1.95). Whereas in women, difficulty in initiating sleep (OR = 1.28, 
      95% CI 1.04-1.57 for "Always"), and maintaining sleep was significantly 
      associated with elevated hs-CRP levels (OR = 1.13, 95% CI 1.02-1.26 for "Often"; 
      OR = 1.11, 95% CI 0.97-1.28 for "Always"). Additionally, women who experienced 
      poor sleep quality presented an elevated level of hs-CRP (OR = 1.13, 95% CI 
      1.03-1.23). Our findings suggest that excessive sleep duration and poor sleep 
      quality are significantly associated with the elevated inflammatory marker, 
      specifically hs-CRP. Further research is needed to examine the effect of sleep 
      interventions focused on these factors.
FAU - Lee, Hwi-Won
AU  - Lee HW
AUID- ORCID: 0000-0002-8480-1395
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Biomedical Sciences, Seoul National University Graduate School, 
      Seoul, Korea.
FAU - Yoon, Hyung-Suk
AU  - Yoon HS
AUID- ORCID: 0000-0003-4519-6337
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Yang, Jae Jeong
AU  - Yang JJ
AUID- ORCID: 0000-0001-6370-2243
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Song, Minkyo
AU  - Song M
AUID- ORCID: 0000-0002-9412-2871
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Lee, Jong-Koo
AU  - Lee JK
AUID- ORCID: 0000-0003-4833-1178
AD  - Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
FAU - Lee, Sang-Ah
AU  - Lee SA
AD  - Department of Preventive Medicine, Kangwon National University School of 
      Medicine, Gangwon, Korea.
FAU - Choi, Ji-Yeob
AU  - Choi JY
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Biomedical Sciences, Seoul National University Graduate School, 
      Seoul, Korea.
FAU - Kang, Daehee
AU  - Kang D
AUID- ORCID: 0000-0003-4031-5878
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
AD  - Department of Biomedical Sciences, Seoul National University Graduate School, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200825
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - C-Reactive Protein/*metabolism
MH  - Female
MH  - *Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea
MH  - Sleep/*physiology
MH  - Time Factors
PMC - PMC7446961
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/08/26 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/08/25
CRDT- 2020/08/26 06:00
PHST- 2019/12/05 00:00 [received]
PHST- 2020/08/08 00:00 [accepted]
PHST- 2020/08/26 06:00 [entrez]
PHST- 2020/08/26 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/08/25 00:00 [pmc-release]
AID - PONE-D-19-33634 [pii]
AID - 10.1371/journal.pone.0238053 [doi]
PST - epublish
SO  - PLoS One. 2020 Aug 25;15(8):e0238053. doi: 10.1371/journal.pone.0238053. 
      eCollection 2020.