PMID- 32841897
OWN - NLM
STAT- MEDLINE
DCOM- 20210217
LR  - 20210217
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 131
DP  - 2020 Nov
TI  - Dysfunction of the neurovascular unit in diabetes-related neurodegeneration.
PG  - 110656
LID - S0753-3322(20)30849-0 [pii]
LID - 10.1016/j.biopha.2020.110656 [doi]
AB  - In current aging societies, diabetes mellitus and neurodegenerative diseases 
      represented by Alzheimer's disease are highly prevalent among adults, especially 
      the elderly all over the world. It is worth noting that a substantial body of 
      evidence suggests diabetes contributes to accelerated neurodegenerative processes 
      and the decline of cognition. Over the last few years, some studies have 
      indicated neurovascular uncoupling and disrupted functional connectivity in the 
      early stages of many neurodegenerative diseases, and the concept of the 
      neurovascular unit (NVU) has been highlighted to understand the initiation and 
      progression of neurodegenerative diseases recently. Considering that some 
      components of the NVU are also demonstrated to have abnormal morphology and 
      function under the condition of diabetes, we propose the hypothesis that diabetes 
      may promote the onset and development of neurodegenerative diseases by impairing 
      the integrity of the NVU, named Diabetes-NVU-Neurodegeneration Hypothesis. The 
      existing body of literature supporting the hypothesis and elucidating the 
      underlying mechanisms will be summarized in this review.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Yan, Caochong
AU  - Yan C
AD  - The Key Laboratory of Reproductive Genetics, Ministry of Education, School of 
      Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Women's 
      Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, 
      China.
FAU - Zhou, Yunxiang
AU  - Zhou Y
AD  - Department of Surgical Oncology, the Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China. Electronic 
      address: yxzhou@zju.edu.cn.
FAU - Chen, Qiang
AU  - Chen Q
AD  - Department of Surgical Oncology, the Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, China.
FAU - Luo, Yi
AU  - Luo Y
AD  - The Second Affiliated Hospital, Zhejiang University School of Medicine (Changxing 
      Branch), Huzhou, Zhejiang, 313100, China.
FAU - Zhang, John H
AU  - Zhang JH
AD  - Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, 
      Loma Linda University, Loma Linda, CA, 92354, USA; Department of Anesthesiology, 
      Neurosurgery and Neurology, Loma Linda University School of Medicine, Loma Linda, 
      CA, 92354, USA. Electronic address: johnzhang3910@yahoo.com.
FAU - Huang, Hefeng
AU  - Huang H
AD  - The Key Laboratory of Reproductive Genetics, Ministry of Education, School of 
      Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Women's 
      Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, 
      China; The International Peace Maternity and Child Health Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. Electronic 
      address: huanghefg@hotmail.com.
FAU - Shao, Anwen
AU  - Shao A
AD  - Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang, 310009, China. Electronic address: 
      21118116@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200822
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
SB  - IM
MH  - Aging/metabolism/pathology
MH  - Alzheimer Disease/etiology/metabolism/pathology
MH  - Animals
MH  - Blood-Brain Barrier/*metabolism/pathology
MH  - Brain/*metabolism/pathology
MH  - Diabetes Complications/metabolism/pathology
MH  - Diabetes Mellitus/*metabolism/pathology
MH  - Humans
MH  - Neurodegenerative Diseases/etiology/*metabolism/pathology
MH  - Neurovascular Coupling/*physiology
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Diabetes mellitus
OT  - Hypothesis
OT  - Neurodegeneration
OT  - Neurovascular unit
EDAT- 2020/08/26 06:00
MHDA- 2021/02/18 06:00
CRDT- 2020/08/26 06:00
PHST- 2020/05/11 00:00 [received]
PHST- 2020/08/10 00:00 [revised]
PHST- 2020/08/17 00:00 [accepted]
PHST- 2020/08/26 06:00 [pubmed]
PHST- 2021/02/18 06:00 [medline]
PHST- 2020/08/26 06:00 [entrez]
AID - S0753-3322(20)30849-0 [pii]
AID - 10.1016/j.biopha.2020.110656 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2020 Nov;131:110656. doi: 10.1016/j.biopha.2020.110656. Epub 
      2020 Aug 22.