PMID- 32842548
OWN - NLM
STAT- MEDLINE
DCOM- 20210311
LR  - 20210311
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 17
DP  - 2020 Aug 23
TI  - Simultaneous Natural Deep Eutectic Solvent-Based Ultrasonic-Assisted Extraction 
      of Bioactive Compounds of Cinnamon Bark and Sappan Wood as a Dipeptidyl Peptidase 
      IV Inhibitor.
LID - 10.3390/molecules25173832 [doi]
LID - 3832
AB  - Cinnamon bark (Cinnamomum burmannii) and sappan wood (Caesalpinia sappan) have 
      been reported to be beneficial for Type-2 Diabetes Mellitus (T2DM) and the 
      combination is commonly used by Indonesian herbal industries. In the present 
      study, the simultaneous extraction of bioactive compounds from both plants was 
      conducted using natural deep eutectic solvent (NADES), their content analyzed 
      using high-performance liquid chromatography (HPLC), and their dipeptidyl 
      peptidase IV (DPP IV) inhibitory activity evaluated. An additional in silico 
      molecular docking analysis was conducted to ensure their activity. The results 
      showed that NADES (with a composition of choline chloride-glycerol) extraction 
      from cinnamon and sappan wood had DPP IV inhibitory activity of 205.0 and 1254.0 
      microg/mL, respectively. Brazilin as a marker substance from sappan wood was 
      responsible for the DPP IV inhibitory activity, while none of the marker 
      substances chosen for cinnamon bark (trans-cinnamaldehyde, coumarin, and 
      trans-cinnamic acid) were found to have significant DPP IV inhibitory activity. 
      These results were confirmed by molecular docking conducted in brazilin, 
      trans-cinnamaldehyde, coumarin, and trans-cinnamic acid.
FAU - Ahmad, Islamudin
AU  - Ahmad I
AUID- ORCID: 0000-0002-7429-9215
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas 
      Mulawarman, Samarinda, East Kalimantan 75119, Indonesia.
FAU - Arifianti, Ayun Erwina
AU  - Arifianti AE
AD  - Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas 
      Indonesia, Depok, West Java 16424, Indonesia.
FAU - Sakti, Aditya Sindu
AU  - Sakti AS
AD  - Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, 
      Depok, West Java 16424, Indonesia.
FAU - Saputri, Fadlina Chany
AU  - Saputri FC
AD  - Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, 
      Depok, West Java 16424, Indonesia.
FAU - Mun'im, Abdul
AU  - Mun'im A
AD  - Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, 
      Depok, West Java 16424, Indonesia.
AD  - Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas 
      Indonesia, Depok, West Java 16424, Indonesia.
LA  - eng
GR  - NKB-458/UN2.RST/HKP.05.00/2020/Kementerian Riset Teknologi Dan Pendidikan Tinggi 
      Republik Indonesia/
PT  - Journal Article
DEP - 20200823
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Dipeptidyl-Peptidase IV Inhibitors)
RN  - EC 3.4.14.5 (Dipeptidyl Peptidase 4)
SB  - IM
MH  - Cinnamomum zeylanicum/*chemistry
MH  - Dipeptidyl Peptidase 4/*chemistry
MH  - *Dipeptidyl-Peptidase IV Inhibitors/chemistry/isolation & purification
MH  - *Molecular Docking Simulation
MH  - Plant Bark/*chemistry
MH  - *Ultrasonic Waves
MH  - Wood/*chemistry
PMC - PMC7504365
OTO - NOTNLM
OT  - Cinnamon bark
OT  - dipeptidyl peptidase IV
OT  - natural deep eutectic solvent
OT  - sappan wood
OT  - ultrasonic-assisted extraction
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2020/08/28 06:00
MHDA- 2021/03/12 06:00
PMCR- 2020/08/23
CRDT- 2020/08/27 06:00
PHST- 2020/08/06 00:00 [received]
PHST- 2020/08/17 00:00 [revised]
PHST- 2020/08/21 00:00 [accepted]
PHST- 2020/08/27 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/03/12 06:00 [medline]
PHST- 2020/08/23 00:00 [pmc-release]
AID - molecules25173832 [pii]
AID - molecules-25-03832 [pii]
AID - 10.3390/molecules25173832 [doi]
PST - epublish
SO  - Molecules. 2020 Aug 23;25(17):3832. doi: 10.3390/molecules25173832.