PMID- 32843669
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Aug 25
TI  - Risk factors for retinopathy in hemodialysis patients with type 2 diabetes 
      mellitus.
PG  - 14158
LID - 10.1038/s41598-020-70998-9 [doi]
LID - 14158
AB  - There is limited knowledge on the prevalence and risk factors of diabetic 
      retinopathy (DR) in dialysis patients. We have investigated the association 
      between diabetes mellitus and lipid-related biomarkers and retinopathy in 
      hemodialysis patients. We reviewed 1,255 hemodialysis patients with type 2 
      diabetes mellitus (T2DM) who participated in the German Diabetes and Dialysis 
      Study (4D Study). Associations between categorical clinical, biochemical 
      variables and diabetic retinopathy were examined by logistic regression. On 
      average, patients were 66 +/- 8 years of age, 54% were male and the HbA1c was 
      6.7% +/- 1.3%. DR, found in 71% of the patients, was significantly and positively 
      associated with fasting glucose, HbA1c, time on dialysis, age, systolic blood 
      pressure, body mass index and the prevalence of other microvascular diseases 
      (e.g. neuropathy). Unexpectedly, DR was associated with high HDL cholesterol and 
      high apolipoproteins AI and AII. Patients with coronary artery disease were less 
      likely to have DR. DR was not associated with gender, smoking, diastolic blood 
      pressure, VLDL cholesterol, triglycerides, and LDL cholesterol. In summary, the 
      prevalence of DR in patients with type 2 diabetes mellitus requiring hemodialysis 
      is higher than in patients suffering from T2DM, who do not receive hemodialysis. 
      DR was positively related to systolic blood pressure (BP), glucometabolic 
      control, and, paradoxically, HDL cholesterol. This data suggests that glucose and 
      blood pressure control may delay the development of DR in patients with diabetes 
      mellitus on dialysis.
FAU - Muller, Michael
AU  - Muller M
AUID- ORCID: 0000-0001-9336-1910
AD  - Department of Ophthalmology, Goethe-University, Theodor Stern Kai 7, 60590, 
      Frankfurt am Main, Germany. michael.mueller@kgu.de.
FAU - Schonfeld, Carl-Ludwig
AU  - Schonfeld CL
AD  - Herzog Carl Theodor Eye Clinic, Munich, Germany.
FAU - Grammer, Tanja
AU  - Grammer T
AD  - Mannheim Institute of Public Health, Social and Preventive Medicine, Medical 
      Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
FAU - Krane, Vera
AU  - Krane V
AD  - Division of Nephrology, Department of Medicine, University Clinic Wurzburg, 
      Wurzburg, Germany.
FAU - Drechsler, Christiane
AU  - Drechsler C
AD  - Division of Nephrology, Department of Medicine, University Clinic Wurzburg, 
      Wurzburg, Germany.
FAU - Genser, Bernd
AU  - Genser B
AD  - Mannheim Institute of Public Health, Social and Preventive Medicine, Medical 
      Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
FAU - Kohnen, Thomas
AU  - Kohnen T
AD  - Department of Ophthalmology, Goethe-University, Theodor Stern Kai 7, 60590, 
      Frankfurt am Main, Germany.
FAU - Wanner, Christoph
AU  - Wanner C
AUID- ORCID: 0000-0001-9507-5301
AD  - Division of Nephrology, Department of Medicine, University Clinic Wurzburg, 
      Wurzburg, Germany.
FAU - Marz, Winfried
AU  - Marz W
AD  - Mannheim Institute of Public Health, Social and Preventive Medicine, Medical 
      Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
AD  - Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical 
      University of Graz, Graz, Austria.
AD  - Synlab Academy, Synlab Services GmbH, Mannheim, Germany.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200825
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Apolipoproteins)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoproteins/blood
MH  - Blindness/epidemiology/etiology
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Comorbidity
MH  - Coronary Disease/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Diabetic Nephropathies/epidemiology/*etiology
MH  - Diabetic Retinopathy/epidemiology/*etiology
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hyperlipidemias/epidemiology
MH  - Hypertension/epidemiology
MH  - Inflammation/epidemiology
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - *Renal Dialysis
MH  - Risk Factors
MH  - Smoking/epidemiology
PMC - PMC7447637
COIS- All authors certify that they have no affiliations with or involvement in any 
      organisation or entity with any financial interest (such as honoraria; 
      educational grants; participation in speakers' bureaus; membership, employment, 
      consultancies, stock ownership, or other equity interest; and expert testimony or 
      patent-licensing agreement), or non-financial interest (such as personal or 
      professional relationships, affiliations, knowledge of beliefs) in the subject 
      matter or materials discussed in this manuscript.
EDAT- 2020/08/28 06:00
MHDA- 2021/01/05 06:00
PMCR- 2020/08/25
CRDT- 2020/08/27 06:00
PHST- 2019/05/01 00:00 [received]
PHST- 2020/08/04 00:00 [accepted]
PHST- 2020/08/27 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2020/08/25 00:00 [pmc-release]
AID - 10.1038/s41598-020-70998-9 [pii]
AID - 70998 [pii]
AID - 10.1038/s41598-020-70998-9 [doi]
PST - epublish
SO  - Sci Rep. 2020 Aug 25;10(1):14158. doi: 10.1038/s41598-020-70998-9.