PMID- 32843916
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1948-0210 (Print)
IS  - 1948-0210 (Electronic)
IS  - 1948-0210 (Linking)
VI  - 12
IP  - 7
DP  - 2020 Jul 26
TI  - Vitamin D and calcium signaling in epidermal stem cells and their regeneration.
PG  - 604-611
LID - 10.4252/wjsc.v12.i7.604 [doi]
AB  - Epidermal stem cells (SCs) residing in the skin play an essential role for 
      epidermal regeneration during cutaneous wound healing. Upon injury, distinct 
      epidermal SCs residing in the interfollicular epidermis and/or hair follicles are 
      activated to proliferate. Subsequently, SCs and progeny migrate, differentiate 
      and restore the epidermis. We review a role of the vitamin D signaling through 
      its receptor of vitamin D receptor (Vdr) in these processes. Vdr conditional 
      knockout (cKO) mouse skin experiences a delay in wound re-epithelialization under 
      low dietary calcium conditions, stimulating our efforts to examine a cooperative 
      role of Vdr with calcium signaling through the calcium sensing receptor in the 
      epidermis. We review the role of vitamin D and calcium signaling in different 
      processes essential for injury induced epidermal regeneration during cutaneous 
      wound repair. First, we discuss their roles in self-renewal of epidermal SCs 
      through beta-catenin signaling. Then, we describe epidermal remodeling, in which SCs 
      and progeny migrate and differentiate to restore the epidermis, events controlled 
      by the E-cadherin mediated adherens junction signaling. Finally, we discuss the 
      potential mechanisms for vitamin D and calcium signaling to regulate injury 
      induced epidermal regeneration mutually and interdependently.
CI  - (c)The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Oda, Yuko
AU  - Oda Y
AD  - Department of Medicine, University of California San Francisco, CA 94158, United 
      States.
FAU - Bikle, Daniel D
AU  - Bikle DD
AD  - Department of Medicine, University of California San Francisco, CA 94158, United 
      States.
LA  - eng
GR  - I01 BX001066/BX/BLRD VA/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Stem Cells
JT  - World journal of stem cells
JID - 101535826
PMC - PMC7415249
OTO - NOTNLM
OT  - Calcium
OT  - Epidermis
OT  - Regeneration
OT  - Stem cells
OT  - Vitamin D
OT  - Wound healing
COIS- Conflict-of-interest statement: Authors declare no conflict of interests for this 
      article.
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/07/26
CRDT- 2020/08/27 06:00
PHST- 2020/02/25 00:00 [received]
PHST- 2020/05/18 00:00 [revised]
PHST- 2020/06/10 00:00 [accepted]
PHST- 2020/08/27 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/07/26 00:00 [pmc-release]
AID - 10.4252/wjsc.v12.i7.604 [doi]
PST - ppublish
SO  - World J Stem Cells. 2020 Jul 26;12(7):604-611. doi: 10.4252/wjsc.v12.i7.604.