PMID- 32844953
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20221124
IS  - 1980-5322 (Electronic)
IS  - 1807-5932 (Print)
IS  - 1807-5932 (Linking)
VI  - 75
DP  - 2020
TI  - microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma.
PG  - e1804
LID - 10.6061/clinics/2020/e1804 [doi]
LID - e1804
AB  - OBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low 
      survival rate and a high metastatic rate. The current work was designed to 
      investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and 
      prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent 
      normal tissues, as well as serum samples from RB patients and healthy controls 
      were measured. The association between miR-144 expression levels and clinical 
      features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in 
      RB were verified by receiver operating characteristic analysis and Kaplan-Meier 
      survival assays. RESULTS: The expression level of miR-144 was markedly decreased 
      in tumor tissues of RB patients, and the expression level of miR-144 was 
      positively associated with tumor size and metastasis in RB patients. Moreover, 
      miR-144 can distinguish tumor tissues from normal tissues with high specificity 
      and sensitivity, and RB patients with lower miR-144 expression have shorter 
      overall and disease-free survival rates than those with higher miR-144 
      expression. Alternatively, miR-144 also decreased in the serum of RB patients in 
      comparison with healthy subjects, and miR-144 expression levels in the tissue 
      samples and serum were positively correlated. Furthermore, miR-144 levels in the 
      serum of RB patients sensitively distinguished RB patients from healthy controls. 
      CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of 
      RB patients and may function as a diagnostic and prognostic marker for RB.
FAU - Zheng, Qian
AU  - Zheng Q
AUID- ORCID: 0000-0002-9334-2741
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
FAU - Zhu, Qin
AU  - Zhu Q
AUID- ORCID: 0000-0003-2186-3828
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
FAU - Li, Cuiping
AU  - Li C
AUID- ORCID: 0000-0002-8021-8039
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
FAU - Hao, Shuang
AU  - Hao S
AUID- ORCID: 0000-0002-3127-9345
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
FAU - Li, Jianguo
AU  - Li J
AUID- ORCID: 0000-0002-6082-3354
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
FAU - Yu, Xin
AU  - Yu X
AUID- ORCID: 0000-0001-8302-8954
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
FAU - Qi, Dengmei
AU  - Qi D
AUID- ORCID: 0000-0001-8721-229X
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
FAU - Pan, Yu
AU  - Pan Y
AUID- ORCID: 0000-0003-3634-2750
AD  - Department of Ophthalmology, Zibo Maternal and Child Health Hospital, Zibo 
      255029, China.
LA  - eng
PT  - Journal Article
DEP - 20200819
PL  - United States
TA  - Clinics (Sao Paulo)
JT  - Clinics (Sao Paulo, Brazil)
JID - 101244734
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MIRN144 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Humans
MH  - *MicroRNAs/genetics
MH  - Prognosis
MH  - *Retinal Neoplasms/diagnosis/genetics
MH  - *Retinoblastoma/diagnosis/genetics
PMC - PMC7426600
COIS- No potential conflict of interest was reported.
EDAT- 2020/08/28 06:00
MHDA- 2020/11/03 06:00
PMCR- 2020/01/01
CRDT- 2020/08/27 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/05/19 00:00 [accepted]
PHST- 2020/08/27 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - S1807-5932(22)00477-X [pii]
AID - cln_75p1 [pii]
AID - 10.6061/clinics/2020/e1804 [doi]
PST - ppublish
SO  - Clinics (Sao Paulo). 2020;75:e1804. doi: 10.6061/clinics/2020/e1804. Epub 2020 
      Aug 19.