PMID- 32845475
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 25
IP  - 2
DP  - 2021 Jun
TI  - Effects of endobronchial coils for endoscopic lung volume reduction on sleep in 
      COPD patients with advanced pulmonary emphysema.
PG  - 727-735
LID - 10.1007/s11325-020-02176-0 [doi]
AB  - PURPOSE: Treatment of advanced pulmonary emphysema with endobronchial coils can 
      improve clinical outcomes like quality of life (QOL). Yet, patients with chronic 
      obstructive pulmonary disease (COPD) are also known to suffer from reduced sleep 
      quality. The effect of coil therapy on sleep has not yet been investigated. The 
      primary aim of this study was to investigate sleep efficiency before and after 
      coil treatment. Secondly, we investigated the effects on nocturnal breathing 
      pattern, QOL, and physical activity. METHODS: Polysomnography (PSG) testing was 
      performed before (T0), 6 month after (T3), and 12 months after (T4) treatment 
      with endobronchial coils. Further examinations included QOL by St George's 
      Respiratory Questionnaire (SGRQ) and COPD assessment test (CAT), and physical 
      activity using an accelerometer for 1 week after each visit. RESULTS: Of 21 
      patients, 14 completed the study: 6 women; mean age 58.0 +/- 4.9 years; BMI 22.6 +/- 
      4.6 kg/m(2); FEV(1) 28.6 +/- 7.1% predicted; residual volume (RV) 278.2 +/- 49.4% 
      predicted. Sleep efficiency did not vary between baseline and follow-up 
      examinations (T0 69.0 +/- 15.8%; T3 70.9 +/- 16.0%; T4 66.8 +/- 18.9%). Non-REM 
      respiratory rate decreased compared to baseline (T0 19.4 +/- 3.9/min; T3 17.8 +/- 
      3.5/min; T4 17.1 +/- 3.1/min (p = 0.041; p = 0.030) and QOL improved meeting the 
      minimal clinically important difference (MCID) (SGRQ, T3 -12.8 units; T4 -7.1 
      units; CAT: T3 -5.6 units; T4 -3.4 units). No increase in physical activity was 
      recorded (light activity T0 31.9 +/- 9.9; T3 30.8 +/- 16.9; T4 26.3 +/- 10.6 h/week). 
      CONCLUSIONS: Treatment with endobronchial coils did not influence objectively 
      measured sleep quality or physical activity, but reduced nocturnal breathing 
      frequency and improved QOL in severe emphysema patients. TRIAL REGISTRATION: 
      ClinicalTrials.gov Identifier: NCT02399514, First Posted: March 26, 2015.
FAU - Franke, Karl-Josef
AU  - Franke KJ
AD  - Markische Kliniken GmbH, Klinikum Ludenscheid, Ludenscheid, Germany.
AD  - Witten-Herdecke University, Witten, Germany.
FAU - Domanski, Ulrike
AU  - Domanski U
AD  - VAMED Klinik Hagen-Ambrock GmbH, Hagen, Germany.
FAU - Schroder, Maik
AU  - Schroder M
AUID- ORCID: 0000-0002-1794-2710
AD  - Kliniken Essen-Mitte, Essen, Germany. m.schroeder@kem-med.com.
FAU - Nilius, Georg
AU  - Nilius G
AD  - Kliniken Essen-Mitte, Essen, Germany.
AD  - Witten-Herdecke University, Witten, Germany.
LA  - eng
SI  - ClinicalTrials.gov/NCT02399514
PT  - Journal Article
DEP - 20200826
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pneumonectomy/*methods
MH  - Pulmonary Disease, Chronic Obstructive/*physiopathology
MH  - Pulmonary Emphysema/physiopathology/*surgery
MH  - Quality of Life
MH  - Sleep/*physiology
MH  - Sleep Quality
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Endobronchial coils
OT  - Lung volume reduction
OT  - PSG
OT  - Physical activity
OT  - Quality of life
OT  - Sleep
EDAT- 2020/08/28 06:00
MHDA- 2021/12/21 06:00
CRDT- 2020/08/27 06:00
PHST- 2020/05/08 00:00 [received]
PHST- 2020/08/19 00:00 [accepted]
PHST- 2020/08/05 00:00 [revised]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2020/08/27 06:00 [entrez]
AID - 10.1007/s11325-020-02176-0 [pii]
AID - 10.1007/s11325-020-02176-0 [doi]
PST - ppublish
SO  - Sleep Breath. 2021 Jun;25(2):727-735. doi: 10.1007/s11325-020-02176-0. Epub 2020 
      Aug 26.