PMID- 32846938
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201022
IS  - 2414-6366 (Electronic)
IS  - 2414-6366 (Linking)
VI  - 5
IP  - 3
DP  - 2020 Aug 24
TI  - HSV-2 Infection as a Potential Cofactor for HIV Disease Progression and Selection 
      of Drug Resistance Mutations in Adults under WHO-Recommended First-Line 
      Antiretroviral Therapy: A Multicentric, Cross-Sectional Study in Cameroon, 
      Central African Republic, Chad, and Gabon.
LID - 10.3390/tropicalmed5030136 [doi]
LID - 136
AB  - Although herpes simplex virus-2 (HSV-2) infection is a known cofactor for HIV 
      transmission in Central Africa, its role in HIV disease progression is unclear. 
      The aim of this study was to examine the potential link between HSV-2 infection 
      and HIV disease progression, in addition to identifying the presence of genes 
      conferring HIV antiretroviral resistance mutations. This was a cross-sectional 
      study involving 302 HIV-infected adults in Central Africa with virological 
      failure (viral load >1000 copies/mL) on first-line antiretroviral therapy from 
      four different countries. The seroprevalence of HSV-2 was 32% (96/302). Amongst 
      the HIV-infected individuals who were HSV-2 seropositive, the mean HIV viral load 
      and CD4 count were 4.82 +/- 0.83 log copies/mL and 243 +/- 144 cells/microliter, 
      respectively. Among the HIV-infected individuals who were HSV-2-seronegative, the 
      mean HIV viral load and CD4 count were 3.48 +/- 0.44 log copies/mL and 646 +/- 212 
      cells/microliter, respectively (p < 0.001). There was a statistically significant 
      relationship (p < 0.001) between HSV-2 seropositivity and the presence of 
      resistance mutations to antiretrovirals (ARV), non-nucleoside reverse 
      transcriptase inhibitors (NNRTI), and nucleoside reverse transcriptase inhibitors 
      (NRTI) with odds ratios of 9.7, 10, and 11.9, respectively. There was no link 
      between HSV-2 serostatus and protease inhibitor (PI) resistance mutations. There 
      was a substantial accumulation of resistance mutations in HSV-2-seropositive 
      compared to -seronegative patients. These findings support the link between HIV 
      disease progression and HSV-2 infection. An association was observed between the 
      presence of NNRTI and NRTI resistance mutations and HSV-2 seropositivity.
FAU - Mihimit, Abdoulaye
AU  - Mihimit A
AD  - Ecole Doctorale d'Infectiologie Tropicale, BP: 876 Franceville, Gabon.
AD  - Centre Hospitalier Universitaire de la Mere et de l'Enfant, BP: 6667 N'Djamena, 
      Chad.
FAU - Adawaye, Chatte
AU  - Adawaye C
AD  - Institut National Superieur des Sciences et Techniques d'Abeche, BP: 130 Abeche, 
      Chad.
FAU - Pere, Helene
AU  - Pere H
AD  - Laboratoire de Microbiologie, Hopital Europeen Georges Pompidou, Assistance 
      Publique-Hopitaux de Paris, and Faculte de Medecine Paris Descartes, Universite 
      Paris Descartes, Sorbonne Paris Cite, 75015 Paris, France.
FAU - Costiniuk, Cecilia
AU  - Costiniuk C
AUID- ORCID: 0000-0002-4547-714X
AD  - Department of Medicine, Divisions of Infectious Diseases/Chronic Viral Illness 
      Service, McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
FAU - Koyalta, Donato
AU  - Koyalta D
AD  - Faculte des Sciences de la Sante Humaine, departement de Medecine, Universite de 
      N'Djamena, BP: 1117 N'Djamena, Chad.
AD  - United Nations Programme on HIV and AIDS UNAIDS, BP: 1146 N'Djamena, Chad.
FAU - Mbopi-Keou, Francois-Xavier
AU  - Mbopi-Keou FX
AD  - National Public Health Laboratory, Ministry of Public Health & University of 
      Yaounde I, P.O. Box: 3601 Yaounde, Cameroon.
FAU - Mboumba Bouassa, Ralph-Sydney
AU  - Mboumba Bouassa RS
AD  - Ecole Doctorale d'Infectiologie Tropicale, BP: 876 Franceville, Gabon.
AD  - Laboratoire de Microbiologie, Hopital Europeen Georges Pompidou, Assistance 
      Publique-Hopitaux de Paris, and Faculte de Medecine Paris Descartes, Universite 
      Paris Descartes, Sorbonne Paris Cite, 75015 Paris, France.
FAU - Talla, Frederic
AU  - Talla F
AD  - Laboratoire d'analyse medicales Litto-Labo, BP: 13038 Douala, Cameroon.
FAU - Moussa, Sandrine
AU  - Moussa S
AD  - Institut Pasteur de Bangui, BP:923 Bangui, Central African Republic.
FAU - Longo, Jean De Dieu
AU  - Longo JD
AD  - Centre National de Reference des Maladies Sexuellement Transmissibles et de la 
      Therapie Antiretrovirale, BP:236 Bangui, Central African Republic.
AD  - Departement de Sante Publique, Faculte des Sciences de la Sante de Bangui, Unite 
      de Recherches et d'Intervention sur les Maladies Sexuellement Transmissibles et 
      le SIDA, BP:923 Bangui, Central African Republic.
FAU - Tchombou, Bertin Hig-Zounet
AU  - Tchombou BH
AD  - Faculte des Sciences de la Sante Humaine, departement de Medecine, Universite de 
      N'Djamena, BP: 1117 N'Djamena, Chad.
FAU - Gresenguet, Gerard
AU  - Gresenguet G
AD  - Departement de Sante Publique, Faculte des Sciences de la Sante de Bangui, Unite 
      de Recherches et d'Intervention sur les Maladies Sexuellement Transmissibles et 
      le SIDA, BP:923 Bangui, Central African Republic.
FAU - Charpentier, Charlotte
AU  - Charpentier C
AD  - Laboratoire de Virologie, Hopital Bichat-Claude Bernard, Assistance 
      Publique-Hopitaux de Paris, 75018 Paris, France.
FAU - Belec, Laurent
AU  - Belec L
AD  - Laboratoire de Microbiologie, Hopital Europeen Georges Pompidou, Assistance 
      Publique-Hopitaux de Paris, and Faculte de Medecine Paris Descartes, Universite 
      Paris Descartes, Sorbonne Paris Cite, 75015 Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20200824
PL  - Switzerland
TA  - Trop Med Infect Dis
JT  - Tropical medicine and infectious disease
JID - 101709042
PMC - PMC7557575
OTO - NOTNLM
OT  - Central Africa
OT  - HIV-1
OT  - HIV-1 RNA load
OT  - HSV-2
OT  - WHO recommendations
OT  - drug resistance mutations
OT  - surrogate markers
COIS- The authors declare that there is no conflict of interest.
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/08/24
CRDT- 2020/08/28 06:00
PHST- 2020/05/23 00:00 [received]
PHST- 2020/07/16 00:00 [revised]
PHST- 2020/07/27 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/08/24 00:00 [pmc-release]
AID - tropicalmed5030136 [pii]
AID - tropicalmed-05-00136 [pii]
AID - 10.3390/tropicalmed5030136 [doi]
PST - epublish
SO  - Trop Med Infect Dis. 2020 Aug 24;5(3):136. doi: 10.3390/tropicalmed5030136.