PMID- 3284731 OWN - NLM STAT- MEDLINE DCOM- 19880614 LR - 20190912 IS - 0012-6578 (Print) IS - 0012-6578 (Linking) VI - 22 IP - 3 DP - 1988 Mar TI - Monoamine oxidase inhibitors: safety and efficacy issues. PG - 232-5 AB - Controversy has historically centered on the use of monoamine oxidase inhibitors (MAOI) in the treatment of depression because of safety and efficacy issues. Hypertensive crisis following ingestion of foods containing tyramine is the most feared problem associated with MAOI therapy. The authors conclude that only four tyramine-containing foods clearly warrant absolute prohibition, but indicate situations where moderation should apply. Although MAOI remain second-line agents in the treatment of endogenous depression, it is unclear whether MAOI or tricyclic antidepressants should be the drugs of choice in atypical depression and this question necessitates future research. FAU - Brown, C S AU - Brown CS AD - Department of Clinical Pharmacy, University of Tennessee, Memphis 38163. FAU - Bryant, S G AU - Bryant SG LA - eng PT - Journal Article PT - Review PL - United States TA - Drug Intell Clin Pharm JT - Drug intelligence & clinical pharmacy JID - 0212457 RN - 0 (Monoamine Oxidase Inhibitors) SB - IM MH - Depressive Disorder/drug therapy MH - Diet MH - Humans MH - Monoamine Oxidase Inhibitors/*adverse effects/therapeutic use RF - 23 EDAT- 1988/03/01 00:00 MHDA- 1988/03/01 00:01 CRDT- 1988/03/01 00:00 PHST- 1988/03/01 00:00 [pubmed] PHST- 1988/03/01 00:01 [medline] PHST- 1988/03/01 00:00 [entrez] AID - 10.1177/106002808802200311 [doi] PST - ppublish SO - Drug Intell Clin Pharm. 1988 Mar;22(3):232-5. doi: 10.1177/106002808802200311.