PMID- 32848203
OWN - NLM
STAT- MEDLINE
DCOM- 20211220
LR  - 20211220
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 45
IP  - 1
DP  - 2021 Jan
TI  - Roux-en-Y gastric bypass and gastric sleeve surgery result in long term bone 
      loss.
PG  - 235-246
LID - 10.1038/s41366-020-00660-x [doi]
AB  - OBJECTIVES: Little is known about the long-term skeletal impact of bariatric 
      procedures, particularly the increasingly commonly performed gastric sleeve 
      surgery (GS). We examined bone density (BMD) change following three types of 
      bariatric surgery Roux-en-Y gastric bypass (RYGB), GS and laparoscopic adjustable 
      gastric banding (LAGB), compared with diet, over 36 months. METHODS: 
      Non-randomized, prospective study of participants with severe obesity (n = 52), 
      undergoing weight-loss interventions: RYGB (n = 7), GS (n = 21), LAGB (n = 11) 
      and diet (n = 13). Measurements of calciotropic indices, gut hormones (fasting 
      and post prandial) peptide YY (PYY), glucagon-like peptide 1 (GLP1) and 
      adiponectin together with dual-X-ray absorptiometry and quantitative computed 
      tomography scans were performed thorough the study. RESULTS: All groups lost 
      weight during the first 12 months. Despite weight stability from 12 to 36 months 
      and supplementation of calcium and vitamin D, there was progressive bone loss at 
      the total hip (TH) over 36 months in RYGB -14% (95% CI: -12, -17) and GS -9% (95% 
      CI: -7, -10). In RYGB forearm BMD also declined over 36 months -9% (95% CI: -6, 
      -12) and LS BMD declined over the first 12 months -7% (95% CI: -3, -12). RYGB and 
      GS groups experienced significantly greater bone loss until 36 months than LAGB 
      and diet groups, which experienced no significant BMD loss. These bone losses 
      remained significant after adjustment for weight loss and age. RYGB and GS 
      procedures resulted in elevated postprandial PYY, adiponectin and bone turnover 
      markers up to 36 months without such changes among LAGB and diet participants. 
      CONCLUSIONS: RYGB and GS but not LAGB resulted in ongoing TH bone loss for three 
      postoperative years. For RYGB, bone loss was also observed at LS and 
      non-weight-bearing forearms. These BMD changes were independent of weight and age 
      differences. We, therefore, recommend close monitoring of bone health following 
      RYGB and GS surgeries.
FAU - Brzozowska, Malgorzata M
AU  - Brzozowska MM
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
AD  - Sutherland and St George Hospitals, Sydney, NSW, Australia.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
FAU - Tran, Thach
AU  - Tran T
AUID- ORCID: 0000-0002-6454-124X
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
FAU - Bliuc, Dana
AU  - Bliuc D
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
FAU - Jorgensen, John
AU  - Jorgensen J
AD  - St George Private Hospital, Sydney, NSW, Australia.
FAU - Talbot, Michael
AU  - Talbot M
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
AD  - St George Private Hospital, Sydney, NSW, Australia.
FAU - Fenton-Lee, Douglas
AU  - Fenton-Lee D
AD  - St Vincent's Private Hospital, Sydney, NSW, Australia.
FAU - Chen, Weiwen
AU  - Chen W
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
FAU - Hong, Angel
AU  - Hong A
AD  - Clinical Chemistry & Endocrinology, NSW Health Pathology, Prince of Wales 
      Hospital, Sydney, NSW, Australia.
FAU - Viardot, Alex
AU  - Viardot A
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
AD  - Department of Endocrinology, St Vincent's Hospital Clinical School, Sydney, NSW, 
      Australia.
FAU - White, Chris P
AU  - White CP
AUID- ORCID: 0000-0002-7732-2206
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
AD  - Clinical Chemistry & Endocrinology, NSW Health Pathology, Prince of Wales 
      Hospital, Sydney, NSW, Australia.
AD  - Department of Endocrinology and Metabolism, Prince of Wales Hospital, Sydney, 
      NSW, Australia.
FAU - Nguyen, Tuan V
AU  - Nguyen TV
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
AD  - University of Notre Dame Australia, School of Medicine Sydney, Sydney, NSW, 
      Australia.
AD  - University of Technology Sydney, Sydney, NSW, Australia.
FAU - Pocock, Nicholas
AU  - Pocock N
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
AD  - Department of Nuclear Medicine, St Vincent's Hospital, Sydney, NSW, Australia.
FAU - Eisman, John A
AU  - Eisman JA
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
AD  - University of Notre Dame Australia, School of Medicine Sydney, Sydney, NSW, 
      Australia.
AD  - Department of Endocrinology, St Vincent's Hospital, Sydney, NSW, Australia.
FAU - Baldock, Paul A
AU  - Baldock PA
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia.
AD  - University of Notre Dame Australia, School of Medicine Sydney, Sydney, NSW, 
      Australia.
FAU - Center, Jacqueline R
AU  - Center JR
AUID- ORCID: 0000-0002-5278-4527
AD  - Osteoporosis and Bone Biology Division, Garvan institute of Medical Research, 
      Sydney, NSW, Australia. j.center@garvan.org.au.
AD  - University of New South Wales Sydney, Faculty of Medicine, Sydney, NSW, 
      Australia. j.center@garvan.org.au.
AD  - University of Notre Dame Australia, School of Medicine Sydney, Sydney, NSW, 
      Australia. j.center@garvan.org.au.
AD  - Department of Endocrinology, St Vincent's Hospital, Sydney, NSW, Australia. 
      j.center@garvan.org.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200826
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
SB  - IM
MH  - Adult
MH  - Bone Density/*physiology
MH  - Female
MH  - *Gastric Bypass/adverse effects/statistics & numerical data
MH  - Humans
MH  - Middle Aged
MH  - Obesity, Morbid/*surgery
MH  - Prospective Studies
MH  - Weight Loss/*physiology
EDAT- 2020/08/28 06:00
MHDA- 2021/12/21 06:00
CRDT- 2020/08/28 06:00
PHST- 2020/03/08 00:00 [received]
PHST- 2020/08/15 00:00 [accepted]
PHST- 2020/07/14 00:00 [revised]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/12/21 06:00 [medline]
PHST- 2020/08/28 06:00 [entrez]
AID - 10.1038/s41366-020-00660-x [pii]
AID - 10.1038/s41366-020-00660-x [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2021 Jan;45(1):235-246. doi: 10.1038/s41366-020-00660-x. Epub 
      2020 Aug 26.