PMID- 32848327
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 0972-8988 (Print)
IS  - 2231-0916 (Electronic)
IS  - 0972-8988 (Linking)
VI  - 13
IP  - 7
DP  - 2020 Jul
TI  - Characterization and identification of charcoal of inedible Kerandang fish 
      (Channa pleurophthalmus Blkr) body parts and potential antiallergenic properties.
PG  - 1480-1486
LID - 10.14202/vetworld.2020.1480-1486 [doi]
AB  - BACKGROUND AND AIM: The study about the antiallergenic properties of inedible 
      fish body parts is still limited. Therefore, this study aimed to characterize the 
      charcoal from the body parts of Kerandang fish (Channa pleurophthalmus Blkr) and 
      identify its antiallergenic properties. MATERIALS AND METHODS: This study used 
      some non-edible body parts extracted from the Kerandang fish (i.e., the scalp, 
      scales, and dorsal, pectoral, ventral, anal, and caudal fins) using a maceration 
      method with different solvents (ethanol, ethyl acetate, and chloroform). The 
      identification of active compounds in the extract was carried out using liquid 
      chromatography-high-resolution mass spectrometry (LC-HRMS) analysis, while the 
      antihyaluronidase activity was determined using the antihyaluronidase test. The 
      highest charcoal antihyaluronidase activity-extract was applied to 
      ovalbumin-induced mice for 7 days with various doses (10, 15, and 20 mg/kg). The 
      specific immunoglobulin E (IgE) was measured using enzyme-linked immunosorbent 
      assay on day 8. RESULTS: Our LC-HRMS analysis showed that the active compound of 
      charcoal in the caudal fins of Kerandang fish was hexadecanamide. The highest 
      inhibition (IC(50)) of hyaluronidase was found in the ethyl acetate extract of 
      fish caudal fins at a concentration of 4 mg/mL. We found that 15 mg/kg body 
      weight of charcoal of fish caudal fins suppressed IgE expression in male mice. 
      CONCLUSION: Our findings indicate that the charcoal of non-edible body parts of 
      Kerandang and one of its constituent, hexadecanamide, may have strong 
      antiallergic effects.
CI  - Copyright: (c) Aryani, et al.
FAU - Aryani, Aryani
AU  - Aryani A
AD  - Doctoral Program, Faculty of Fisheries and Marine Sciences, Brawijaya University, 
      Malang 65145, East Java, Indonesia.
FAU - Suprayitno, Eddy
AU  - Suprayitno E
AD  - Department of Fisheries Product Technology, Faculty of Fisheries and Marine 
      Sciences, Brawijaya University, Malang 65145, East Java, Indonesia.
FAU - Sasmito, Bambang Budi
AU  - Sasmito BB
AD  - Department of Fisheries Product Technology, Faculty of Fisheries and Marine 
      Sciences, Brawijaya University, Malang 65145, East Java, Indonesia.
FAU - Hardoko, Hardoko
AU  - Hardoko H
AD  - Department of Fisheries Product Technology, Faculty of Fisheries and Marine 
      Sciences, Brawijaya University, Malang 65145, East Java, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20200730
PL  - India
TA  - Vet World
JT  - Veterinary world
JID - 101504872
PMC - PMC7429384
OTO - NOTNLM
OT  - Kerandang fish
OT  - anti-allergy
OT  - charcoal
OT  - hyaluronidase
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/07/01
CRDT- 2020/08/28 06:00
PHST- 2020/02/26 00:00 [received]
PHST- 2020/06/05 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - Vetworld-13-1480 [pii]
AID - 10.14202/vetworld.2020.1480-1486 [doi]
PST - ppublish
SO  - Vet World. 2020 Jul;13(7):1480-1486. doi: 10.14202/vetworld.2020.1480-1486. Epub 
      2020 Jul 30.