PMID- 32848550
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia 
      Induced by Plantar Incision in Mice.
PG  - 766
LID - 10.3389/fnins.2020.00766 [doi]
LID - 766
AB  - Poor postoperative pain (POP) control increases perioperative morbidity, prolongs 
      hospitalization days, and causes chronic pain. However, the specific mechanism(s) 
      underlying POP is unclear and the identification of optimal perioperative 
      treatment remains elusive. Akt and mammalian target of rapamycin (mTOR) are 
      expressed in the spinal cord, dorsal root ganglion, and sensory axons. In this 
      study, we explored the role of Akt and mTOR in pain-related behaviors induced by 
      plantar incision in mice. Plantar incision activated spinal Akt and mTOR in a 
      dose-dependent manner. Pre-treatment with Akt inhibitors intrathecally prevented 
      the activation of mTOR dose-dependently. In addition, blocking the Akt-mTOR 
      signaling cascade attenuated pain-related behaviors and spinal Fos protein 
      expression induced by plantar incision. Our observations demonstrate that 
      Akt-mTOR might be a potential therapeutic target for the treatment of POP.
CI  - Copyright (c) 2020 Xu, Liu, Wei, Jiao, Mo, Lv, Huang, Chen, Ma and Guan.
FAU - Xu, Bing
AU  - Xu B
AD  - Department of Rehabilitation, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Liu, Su-Su
AU  - Liu SS
AD  - Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Wei, Jin
AU  - Wei J
AD  - Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Jiao, Zi-Yin
AU  - Jiao ZY
AD  - Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Mo, Cheng
AU  - Mo C
AD  - Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Lv, Cheng-Mei
AU  - Lv CM
AD  - Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Huang, Ai-Lan
AU  - Huang AL
AD  - Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Chen, Qi-Bo
AU  - Chen QB
AD  - Department of Rehabilitation, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Ma, Li
AU  - Ma L
AD  - Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous 
      Region, Nanning, China.
FAU - Guan, Xue-Hai
AU  - Guan XH
AD  - Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
LA  - eng
PT  - Journal Article
DEP - 20200722
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7396510
OTO - NOTNLM
OT  - incisional pain
OT  - mice
OT  - protein kinase B
OT  - spinal dorsal corn
OT  - the mammalian target of rapamycin kinase
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/01/01
CRDT- 2020/08/28 06:00
PHST- 2020/02/19 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.00766 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Jul 22;14:766. doi: 10.3389/fnins.2020.00766. eCollection 
      2020.