PMID- 32849829
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 11
DP  - 2020
TI  - Genome-Wide Association Study Using Individual Single-Nucleotide Polymorphisms 
      and Haplotypes for Erythrocyte Traits in Alpine Merino Sheep.
PG  - 848
LID - 10.3389/fgene.2020.00848 [doi]
LID - 848
AB  - Adaptation to high-altitude hypoxia is essential for domestic animals, such as 
      yak, Tibetan chicken, and Tibetan sheep, living on high plateaus, as it ensures 
      efficient oxygen absorption and utilization. Red blood cells are the primary 
      medium for transporting oxygen in the blood. However, little is known about the 
      genetic mechanism of erythrocyte traits. Genome-wide association studies (GWASs) 
      based on single markers or haplotypes have identified potential mechanisms for 
      genetic variation and quantitative traits. To identify loci associated with 
      erythrocyte traits, we performed a GWAS based on the method of the single marker 
      and haplotype in 498 Alpine Merino sheep for six erythrocyte traits: red blood 
      cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular hemoglobin 
      (MCH), mean corpuscular hemoglobin concentration (MCHC), and RBC volume 
      distribution width coefficient of variation (RWD_CV). Forty-two significant 
      single-nucleotide polymorphisms (SNPs) associated with the six erythrocyte traits 
      were detected by means of a single-marker GWAS, and 34 significant haplotypes 
      associated with five erythrocyte traits were detected by means of haplotype 
      analysis. We identified six genes (DHCR24, SPATA9, FLI1, PLCB1, EFNB2, and SH2B3) 
      as potential genes of interest via gene function annotations, location, and 
      expression variation. In particular, FLI1 and PLCB1 were associated with 
      hematopoiesis and erythropoiesis, respectively. These results provide a 
      theoretical basis for analyzing erythrocyte traits and high-altitude hypoxia 
      adaptation in Alpine Merino sheep and will be a useful reference for future 
      studies of plateau-dwelling livestock.
CI  - Copyright (c) 2020 Zhu, Guo, Zhao, Qiao, Han, Liu, Yuan, Wang, Li, Yue and Yang.
FAU - Zhu, Shaohua
AU  - Zhu S
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Guo, Tingting
AU  - Guo T
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Zhao, Hongchang
AU  - Zhao H
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Qiao, Guoyan
AU  - Qiao G
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Han, Mei
AU  - Han M
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Liu, Jianbin
AU  - Liu J
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Yuan, Chao
AU  - Yuan C
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Wang, Tianxiang
AU  - Wang T
AD  - Gansu Provincial Sheep Breeding Technology Extension Station, Sunan, China.
FAU - Li, Fanwen
AU  - Li F
AD  - Gansu Provincial Sheep Breeding Technology Extension Station, Sunan, China.
FAU - Yue, Yaojing
AU  - Yue Y
AD  - Sheep Breeding Engineering Technology Center, Chinese Academy of Agricultural 
      Sciences, Lanzhou, China.
FAU - Yang, Bohui
AU  - Yang B
AD  - Animal Science Department, Lanzhou Institute of Husbandry and Pharmaceutical 
      Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200731
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC7411260
OTO - NOTNLM
OT  - alpine merino sheep
OT  - erythrocyte traits
OT  - genome-wide association study
OT  - haplotype
OT  - high-altitude hypoxia adaptation
OT  - single-nucleotide polymorphism
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/07/31
CRDT- 2020/08/28 06:00
PHST- 2020/04/03 00:00 [received]
PHST- 2020/07/13 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/07/31 00:00 [pmc-release]
AID - 10.3389/fgene.2020.00848 [doi]
PST - epublish
SO  - Front Genet. 2020 Jul 31;11:848. doi: 10.3389/fgene.2020.00848. eCollection 2020.