PMID- 32849886
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1728-1997 (Print)
IS  - 2252-0589 (Electronic)
IS  - 2252-0589 (Linking)
VI  - 21
IP  - 2
DP  - 2020 Spring
TI  - Cardiorespiratory effects of epidurally administered ketamine or lidocaine in 
      dogs undergoing ovariohysterectomy surgery: a comparative study.
PG  - 92-96
AB  - BACKGROUND: Analgesic and hemodynamic effects of ketamine in subanesthetic doses 
      during surgical anesthesia and postoperative, are due to the action on the 
      N-methyl-D-aspartate receptors (NMDAR). AIMS: To evaluate the intraoperative 
      cardiorespiratory effects provided by ketamine compared to lidocaine, both 
      administered epidurally, in bitches submitted to ovariohysterectomy. METHODS: 
      Thirty-six dogs of different breeds were used in a randomized, prospective, and 
      blinded clinical trial. Two groups were formed: G(KET) (ketamine 3 mg/kg, n=18) 
      and G(LIDO) (lidocaine 4 mg/kg, n=18). Animals were premedicated with 
      acepromazine 0.05 mg/kg intravenous. Anesthesia was induced with propofol 5 mg/kg 
      intravenous. Anesthetic maintenance was performed with isoflurane in 100% oxygen. 
      Every 5 min during surgery, heart rate (HR), respiratory rate (RR), esophageal 
      temperature ( degrees C), oxygen saturation (SPO(2)), end tidal carbon dioxide (ETCO(2)) 
      and mean arterial pressure (MAP) were monitored. RESULTS: Cardiorespiratory 
      variables during anesthesia were within normal ranges. Heart rate was 
      significantly higher at 5 (108 +/- 12 vs 95 +/- 11) and 10 (110 +/- 11 vs 97 +/- 11) min 
      in G(KET) compared to G(LIDO) after the start of surgery (P=0.03 and P=0.01, 
      respectively). Mean arterial pressure was higher in G(KET), (100 +/- 23, 105 +/- 35, 
      and 103 +/- 35 mmHg) in comparison with G(LIDO) (66 +/- 7, 74 +/- 10, and 67 +/- 9 mmHg) 
      at 20, 25 and 30 min (P=0.01, P=0.004, and P=0.002, respectively). Mild 
      hypothermia at 25 (36.5 1.3C) and 30 (36.5 1.4C) min in the G(KET) was recorded. 
      CONCLUSION: Epidural administration of ketamine provides better hemodynamic 
      stability, compared to the use of epidural lidocaine.
FAU - Miranda-Cortes, A E
AU  - Miranda-Cortes AE
AD  - Section of Pharmacology and Veterinary Therapeutics, Department of Clinical 
      Pharmacology and Veterinary Anesthesia, Faculty of Higher Studies Cuautitlan, 
      National Autonomous University of Mexico, Cuautitlan Izcalli, Mexico State, 
      54714, Mexico.
FAU - Ruiz-Garcia, A G
AU  - Ruiz-Garcia AG
AD  - Section of Pharmacology and Veterinary Therapeutics, Department of Clinical 
      Pharmacology and Veterinary Anesthesia, Faculty of Higher Studies Cuautitlan, 
      National Autonomous University of Mexico, Cuautitlan Izcalli, Mexico State, 
      54714, Mexico.
FAU - Olivera-Ayub, A E
AU  - Olivera-Ayub AE
AD  - Department of Surgery, Faculty of Veterinary Medicine, National Autonomous 
      University of Mexico, Mexico City, 04510, Mexico.
FAU - Garza-Malacara, G
AU  - Garza-Malacara G
AD  - Department of Canine Clinic, Faculty of Higher Studies Cuautitlan, National 
      Autonomous University of Mexico, Mexico State, 54714, Mexico.
FAU - Ruiz-Cervantes, J G
AU  - Ruiz-Cervantes JG
AD  - Department of Biological Sciences, and Clinical Pharmacology and Veterinary 
      Anesthesia, Faculty of Higher Studies Cuautitlan, National Autonomous University 
      of Mexico, Cuautitlan Izcalli, Mexico State, 54714, Mexico.
FAU - Toscano-Zapien, J A
AU  - Toscano-Zapien JA
AD  - MSc Student in Neurology Area, Research Unit of Pediatric Hospital Century XXI, 
      Mexican Social Security Institute, Mexico City, 06725, Mexico.
FAU - Hernandez-Avalos, I
AU  - Hernandez-Avalos I
AD  - Department of Biological Sciences, and Clinical Pharmacology and Veterinary 
      Anesthesia, Faculty of Higher Studies Cuautitlan, National Autonomous University 
      of Mexico, Cuautitlan Izcalli, Mexico State, 54714, Mexico.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Vet Res
JT  - Iranian journal of veterinary research
JID - 101660030
PMC - PMC7430370
OTO - NOTNLM
OT  - Analgesia
OT  - Dog
OT  - Epidural
OT  - Ketamine
OT  - Lidocaine
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/03/01
CRDT- 2020/08/28 06:00
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/03/01 00:00 [pmc-release]
AID - IJijvr-21-092 [pii]
PST - ppublish
SO  - Iran J Vet Res. 2020 Spring;21(2):92-96.