PMID- 32850310
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 10
DP  - 2020
TI  - Circular RNA 103862 Promotes Proliferation and Invasion of Laryngeal Squamous 
      Cell Carcinoma Cells Through the miR-493-5p/GOLM1 Axis.
PG  - 1064
LID - 10.3389/fonc.2020.01064 [doi]
LID - 1064
AB  - Accumulating evidence suggests that circular RNAs (circRNAs) may be a key 
      contributor to oncogenesis. Yet, the function of circRNAs in laryngeal squamous 
      cell carcinoma (LSCC) is still not clear. In this study, we examined the function 
      of circRNA_103862 in LSCC progression by analyzing the tissue specimens collected 
      from a patient with LSCC by using different LSCC cell models in vitro and an LSCC 
      xenograft model in nude mice. We found that circRNA_103862 was frequently 
      upregulated in the tissues of LSCC and was correlated with metastasis and 
      prognosis of LSCC patients. Furthermore, circRNA_103862 downregulation could 
      reduce proliferation, migration, and invasion ability of LSCC cells. In terms of 
      mechanism exploration, miR-493-5p was sponged by circRNA_103862. Rescue 
      experiments also showed that circRNA_103862 could achieve a carcinogenic effect 
      by regulating miR-493-5p. Moreover, a luciferase reporter analysis showed that 
      Golgi membrane protein 1 (GOLM1) is a downstream effector of miR-493-5p. In 
      conclusion, our data suggested that circRNA_103862 promotes the proliferation of 
      LSCC through targeting the miR-493-5p/GOLM1 axis, and it might serve as a 
      potential prognosis marker and therapy target for LSCC.
CI  - Copyright (c) 2020 Wang, Wu, Wang, Yang, Li, Wang, Zhao, Zhang, Liu, Cao, Tian, Yu 
      and Sun.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Wu, Tianyi
AU  - Wu T
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Henan Provincial 
      People's Hospital, Zhengzhou University People's Hospital, Henan University 
      People's Hospital, Zhengzhou, China.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Yang, Like
AU  - Yang L
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Li, Qiuying
AU  - Li Q
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Wang, Jingting
AU  - Wang J
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Zhao, Rui
AU  - Zhao R
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Zhang, Jiarui
AU  - Zhang J
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Cao, Jing
AU  - Cao J
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Tian, Linli
AU  - Tian L
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Yu, Boyu
AU  - Yu B
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
FAU - Sun, Yanan
AU  - Sun Y
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, Harbin, China.
LA  - eng
PT  - Journal Article
DEP - 20200729
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC7405723
OTO - NOTNLM
OT  - GOLM1
OT  - LSCC
OT  - circRNA_103862
OT  - circular RNA
OT  - miR-493-5p
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/01/01
CRDT- 2020/08/28 06:00
PHST- 2020/02/24 00:00 [received]
PHST- 2020/05/28 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2020.01064 [doi]
PST - epublish
SO  - Front Oncol. 2020 Jul 29;10:1064. doi: 10.3389/fonc.2020.01064. eCollection 2020.