PMID- 32851070
OWN - NLM
STAT- MEDLINE
DCOM- 20210429
LR  - 20220416
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2020
DP  - 2020
TI  - Effects of Antiacid Therapy on Granuloma after Transoral Type IV-VI Cordectomy in 
      Patients with Early-Stage Glottic Cancer.
PG  - 4178376
LID - 10.1155/2020/4178376 [doi]
LID - 4178376
AB  - OBJECTIVE: To investigate whether preventive administration of a proton pump 
      inhibitor (PPI) can reduce the occurrence and development of traumatic granuloma 
      (TG) following type IV-VI cordectomy. METHODS: We retrospectively analyzed the 
      status of postoperative granulomas in 37 patients who underwent type IV-VI 
      cordectomy due to glottic cancer and determined whether postoperative 
      administration of a PPI had any impact on granuloma formation and development. 
      RESULTS: The percentage and number of patients with granuloma in the PPI 
      treatment group (experimental group) at the 1st, 2nd, 3rd, and 6th month 
      following surgery were 81.25% (13/16), 25.00% (4/16), 18.75% (3/16), and 0.00% 
      (0/16), respectively. The percentage and number of patients with granuloma in the 
      no-PPI group (control group) were 95.24% (20/21), 71.43% (15/21), 52.38% (11/21), 
      and 14.29% (3/21), respectively. The granuloma percentage of the PPI treatment 
      group was lower than that of the control group at all postoperative time points 
      assessed. The differences were not statistically significant at the 1st month (p 
      = 0.175) but were statistically significant at the 2nd and 3rd months after 
      surgery (p = 0.005, p = 0.037). CONCLUSION: Preventive use of a PPI in patients 
      after type IV-VI cordectomy can shorten the TG recovery duration and may reduce 
      the severity of TG, but it cannot prevent TG from occurring. Our results should 
      be confirmed by prospective randomized controlled trials with large sample sizes.
CI  - Copyright (c) 2020 Xiaofeng Jin et al.
FAU - Jin, Xiaofeng
AU  - Jin X
AUID- ORCID: 0000-0003-3140-9389
AD  - Department of Otolaryngology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Science and Peking Union Medical College, Beijing 100005, 
      China.
AD  - Department of Otolaryngology, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumchi, 830011 Xinjiang Uygur Autonomous Region, China.
FAU - Niu, Yanyan
AU  - Niu Y
AUID- ORCID: 0000-0001-7275-2787
AD  - Department of Otolaryngology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Science and Peking Union Medical College, Beijing 100005, 
      China.
FAU - Gu, Wei
AU  - Gu W
AD  - Department of Otolaryngology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Science and Peking Union Medical College, Beijing 100005, 
      China.
FAU - Wang, Jian
AU  - Wang J
AUID- ORCID: 0000-0002-6261-7829
AD  - Department of Otolaryngology, Peking Union Medical College Hospital, Chinese 
      Academy of Medical Science and Peking Union Medical College, Beijing 100005, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200810
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Combined Modality Therapy
MH  - Female
MH  - Glottis/drug effects/pathology/*surgery
MH  - Granuloma/*drug therapy/pathology/surgery
MH  - Humans
MH  - Laryngeal Neoplasms/*drug therapy/pathology/surgery
MH  - Laser Therapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Postoperative Period
MH  - Progression-Free Survival
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Vocal Cords/pathology/surgery
MH  - Voice Quality
PMC - PMC7436350
COIS- The authors declare that they have no conflicts of interest (financial or 
      nonfinancial) to disclose.
EDAT- 2020/08/28 06:00
MHDA- 2021/04/30 06:00
PMCR- 2020/08/10
CRDT- 2020/08/28 06:00
PHST- 2020/03/31 00:00 [received]
PHST- 2020/07/13 00:00 [revised]
PHST- 2020/07/18 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/04/30 06:00 [medline]
PHST- 2020/08/10 00:00 [pmc-release]
AID - 10.1155/2020/4178376 [doi]
PST - epublish
SO  - Biomed Res Int. 2020 Aug 10;2020:4178376. doi: 10.1155/2020/4178376. eCollection 
      2020.