PMID- 32851096
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - Low Bone Turnover Markers in Young and Middle-Aged Male Patients with Type 2 
      Diabetes Mellitus.
PG  - 6191468
LID - 10.1155/2020/6191468 [doi]
LID - 6191468
AB  - Accumulating evidence has supported an increased risk of osteoporotic fracture in 
      postmenopausal women and elderly men diagnosed with diabetes mellitus. However, 
      it is not uncommon for young and middle-aged male patients diagnosed with type 2 
      diabetes mellitus (T2DM) to suffer from osteopenia or osteoporosis. Few studies 
      focused on this population group are available. The aim of this study is to 
      evaluate bone metabolic status and investigate the influence of T2DM on bone 
      metabolism in 30-50-year-old men. Anthropometric assessment and blood samples 
      were obtained from 160 patients with T2DM and 69 nondiabetic volunteers. Serum 
      parathyroid hormone (PTH) and bone turnover markers (BTMs), including serum 
      procollagen type I N-terminal peptide (PINP), osteocalcin (OC), and 
      beta-cross-linked C-telopeptide of type I collagen (beta-CTX), were analysed. No 
      significant differences were observed based on age, body mass index, systolic 
      blood pressure, serum calcium, phosphorus, creatinine, total protein, and albumin 
      levels when comparing T2DM and control groups. Fasting blood glucose, HbA1c, 
      triglyceride (TG), total cholesterol, and low-density lipoprotein cholesterol 
      were significantly increased, while high-density lipoprotein cholesterol was 
      significantly decreased in the T2DM group. Compared with controls, diabetic 
      patients showed lower serum PINP, OC, and PTH levels, whereas serum beta-CTX levels 
      were similar between the two groups. Moreover, HbA1c levels were positively 
      correlated with PINP and inversely associated with PTH levels. TG levels were 
      negatively correlated with OC or beta-CTX levels. Furthermore, multiple linear 
      regression revealed a positive correlation between HbA1c and PINP levels. These 
      results also revealed a negative association between HbA1c and PTH, and between 
      TG and OC levels, even after adjusting for expected confounder factors. 
      Collectively, these findings indicated that young and middle-aged male patients 
      with T2DM showed a lower turnover state resulting from bone formation inhibition. 
      Glucose and lipid metabolic disorders may affect bone formation through different 
      pathways.
CI  - Copyright (c) 2020 X. X. Liu et al.
FAU - Liu, X X
AU  - Liu XX
AUID- ORCID: 0000-0002-8950-2976
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin 300134, China.
FAU - Jiang, L
AU  - Jiang L
AUID- ORCID: 0000-0003-3336-8998
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin 300134, China.
FAU - Liu, Q
AU  - Liu Q
AUID- ORCID: 0000-0001-6192-5582
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin 300134, China.
FAU - Zhang, J
AU  - Zhang J
AUID- ORCID: 0000-0002-5081-7698
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin 300134, China.
FAU - Niu, W
AU  - Niu W
AUID- ORCID: 0000-0001-7481-1576
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin 300134, China.
FAU - Liu, J
AU  - Liu J
AUID- ORCID: 0000-0002-1942-6752
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin 300134, China.
FAU - Zhang, Q
AU  - Zhang Q
AUID- ORCID: 0000-0001-5251-6170
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of 
      Endocrinology, Tianjin Medical University, Tianjin 300134, China.
LA  - eng
PT  - Journal Article
DEP - 20200810
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type I)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides)
RN  - 0 (Procollagen)
RN  - 0 (collagen type I trimeric cross-linked peptide)
RN  - 0 (procollagen Type I N-terminal peptide)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Bone Remodeling/*physiology
MH  - Collagen Type I/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/*blood
MH  - Parathyroid Hormone/*blood
MH  - Peptide Fragments/*blood
MH  - Peptides/*blood
MH  - Procollagen/*blood
PMC - PMC7436354
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this paper.
EDAT- 2020/08/28 06:00
MHDA- 2021/07/10 06:00
PMCR- 2020/08/10
CRDT- 2020/08/28 06:00
PHST- 2020/04/27 00:00 [received]
PHST- 2020/07/10 00:00 [revised]
PHST- 2020/07/28 00:00 [accepted]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/08/10 00:00 [pmc-release]
AID - 10.1155/2020/6191468 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 Aug 10;2020:6191468. doi: 10.1155/2020/6191468. eCollection 
      2020.