PMID- 32851296 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240329 IS - 2574-2272 (Electronic) IS - 2096-3726 (Print) IS - 2574-2272 (Linking) VI - 3 IP - 2 DP - 2019 Jun TI - Kawasaki disease shock syndrome: A report of two cases and literature review. PG - 81-85 LID - 10.1002/ped4.12127 [doi] AB - IMPORTANCE: Kawasaki disease shock syndrome (KDSS) is a rare Kawasaki disease (KD) manifestation. The pediatricians are not aware of the full range of clinical characteristics of KDSS. OBJECTIVE: We aimed to investigate the clinical features, diagnosis and treatment of KDSS in two patients and we included a literature review. METHODS: We collected and analyzed the clinical data for two patients with KDSS. Additionally, using "Kawasaki diseases shock syndrome" as a key phrase, we searched PubMed, Biotechnology Information and Wanfang Data Knowledge Service Platform databases for any similar reports between January 2009 and March 2017. RESULTS: Both of our patients diagnosed with KD developed sustained hypotension during the course of intravenous immunoglobulin treatment, as well as hypoalbuminemia, and increased C-reactive protein and brain natriuretic peptide levels during hypotension. Both patients responded well to fluid resuscitation and inotropic support. No aneurysms formed in either patient during follow-up. We reviewed two related studies in Chinese and 11 studies in English. INTERPRETATION: KD may present with severe shock, and requires proper diagnosis and rapid treatment. The prognosis for most patients with KDSS is excellent. CI - (c) 2019 Chinese Medical Association. Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. FAU - Zhang, Qingyou AU - Zhang Q AD - Department of Pediatrics Peking University First Hospital Beijing China. FAU - Liao, Ying AU - Liao Y AD - Department of Pediatrics Peking University First Hospital Beijing China. FAU - Du, Junbao AU - Du J AD - Department of Pediatrics Peking University First Hospital Beijing China. LA - eng PT - Journal Article DEP - 20190625 PL - United States TA - Pediatr Investig JT - Pediatric investigation JID - 101731527 PMC - PMC7331343 OTO - NOTNLM OT - Brain natriuretic peptide OT - Children OT - Kawasaki disease OT - Shock COIS- None. EDAT- 2019/06/25 00:00 MHDA- 2019/06/25 00:01 PMCR- 2019/06/25 CRDT- 2020/08/28 06:00 PHST- 2018/11/02 00:00 [received] PHST- 2019/02/26 00:00 [accepted] PHST- 2020/08/28 06:00 [entrez] PHST- 2019/06/25 00:00 [pubmed] PHST- 2019/06/25 00:01 [medline] PHST- 2019/06/25 00:00 [pmc-release] AID - PED412127 [pii] AID - 10.1002/ped4.12127 [doi] PST - epublish SO - Pediatr Investig. 2019 Jun 25;3(2):81-85. doi: 10.1002/ped4.12127. eCollection 2019 Jun.