PMID- 32851538
OWN - NLM
STAT- MEDLINE
DCOM- 20210510
LR  - 20210510
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 42
IP  - 4
DP  - 2021 Apr
TI  - Connected speech in progressive supranuclear palsy: a possible role in 
      differential diagnosis.
PG  - 1483-1490
LID - 10.1007/s10072-020-04635-8 [doi]
AB  - BACKGROUND: Progressive supranuclear palsy (PSP) is an atypical Parkinsonism 
      characterized by motor and neuropsycological disorders. Language could be 
      impaired in PSP patients, also in Richardson variant (PSP-RS). The analysis of 
      connected speech is used in neurodegenerative disorder to investigate different 
      levels of language organization, including phonetic, phonological, 
      lexico-semantic, morpho-syntactic, and pragmatic processing. OBJECTIVE: In our 
      study, we aimed to investigate the language profile, especially connected speech, 
      in early-stage PSP-RS and Parkinson's disease (PD) patients without predominant 
      speech or language disorders. METHODS: Language was assessed using the Screening 
      for Aphasia in NeuroDegeneration (SAND); connected speech analysis was conducted 
      from the picture description subtest. RESULTS: We enrolled 48 patients, 22 PD and 
      26 PSP (18 PSP-RS and 8 non-RS). PSP-RS patients presented an impairment in 
      language domain, particularly regarding connected speech. PSP-RS patients 
      presented worse performances than PD in different scores. The output of PSP-RS 
      patients was characterized by a reduction in number of sentences and subordinates 
      with respect to PD; PSP presented also more repaired sequences and phonological 
      and lexico-semantic errors than PD. Number of sentences and number of 
      subordinates of the picture description task were identified as predictors of PSP 
      diagnosis. CONCLUSION: In summary, the SAND scale is able to identify language 
      impairment in PSP patients. The analysis of connected speech could highlight some 
      important aspects of language impairment in PSP-RS patients, and it could be 
      helpful in the differential diagnosis with PD.
FAU - Del Prete, Eleonora
AU  - Del Prete E
AD  - Clinical and Experimental Medicine Department, Neurology Unit, University of 
      Pisa, Via Roma 67, Pisa, Italy.
FAU - Tommasini, Luca
AU  - Tommasini L
AD  - Clinical and Experimental Medicine Department, Neurology Unit, University of 
      Pisa, Via Roma 67, Pisa, Italy.
FAU - Mazzucchi, Sonia
AU  - Mazzucchi S
AD  - Clinical and Experimental Medicine Department, Neurology Unit, University of 
      Pisa, Via Roma 67, Pisa, Italy.
FAU - Frosini, Daniela
AU  - Frosini D
AD  - Neurology Unit, Department of Medical Specialties, AOUP, Pisa, Italy.
FAU - Palermo, Giovanni
AU  - Palermo G
AD  - Clinical and Experimental Medicine Department, Neurology Unit, University of 
      Pisa, Via Roma 67, Pisa, Italy.
FAU - Morganti, Riccardo
AU  - Morganti R
AD  - Section of Statistics, University Hospital of Pisa, Pisa, Italy.
FAU - Pagni, Cristina
AU  - Pagni C
AD  - Clinical and Experimental Medicine Department, Neurology Unit, University of 
      Pisa, Via Roma 67, Pisa, Italy.
FAU - Tognoni, Gloria
AU  - Tognoni G
AD  - Neurology Unit, Department of Medical Specialties, AOUP, Pisa, Italy.
FAU - Bonuccelli, Ubaldo
AU  - Bonuccelli U
AD  - Clinical and Experimental Medicine Department, Neurology Unit, University of 
      Pisa, Via Roma 67, Pisa, Italy.
FAU - Ceravolo, Roberto
AU  - Ceravolo R
AUID- ORCID: 0000-0003-1412-9406
AD  - Clinical and Experimental Medicine Department, Neurology Unit, University of 
      Pisa, Via Roma 67, Pisa, Italy. roberto.ceravolo@unipi.it.
LA  - eng
PT  - Journal Article
DEP - 20200827
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
SB  - IM
MH  - Diagnosis, Differential
MH  - Humans
MH  - *Parkinson Disease/complications/diagnosis
MH  - *Parkinsonian Disorders
MH  - *Speech
MH  - *Supranuclear Palsy, Progressive/complications/diagnosis
OTO - NOTNLM
OT  - Connected speech
OT  - Language
OT  - Progressive supranuclear palsy
OT  - SAND
EDAT- 2020/08/28 06:00
MHDA- 2021/05/11 06:00
CRDT- 2020/08/28 06:00
PHST- 2020/05/16 00:00 [received]
PHST- 2020/07/30 00:00 [accepted]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/05/11 06:00 [medline]
PHST- 2020/08/28 06:00 [entrez]
AID - 10.1007/s10072-020-04635-8 [pii]
AID - 10.1007/s10072-020-04635-8 [doi]
PST - ppublish
SO  - Neurol Sci. 2021 Apr;42(4):1483-1490. doi: 10.1007/s10072-020-04635-8. Epub 2020 
      Aug 27.