PMID- 32852748
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20210823
IS  - 1864-6433 (Electronic)
IS  - 0914-7187 (Linking)
VI  - 34
IP  - 11
DP  - 2020 Nov
TI  - Regional gray matter-dedicated SUVR with 3D-MRI detects positive amyloid deposits 
      in equivocal amyloid PET images.
PG  - 856-863
LID - 10.1007/s12149-020-01513-3 [doi]
AB  - PURPOSE: It is usually easy to judge whether amyloid PET images should be 
      interpreted as positive or negative for amyloid deposits by visual inspection or 
      quantitative measurement standard uptake value ratio (SUVR), but the findings are 
      equivocal in some cases. As conventional mean cortical SUVR (mcSUVR) measures 
      accumulation in both gray matter (GM) and white matter, it may mis-estimate 
      amyloid deposits. The purpose of the study was to develop a regional GM-dedicated 
      SUVR measuring (GMSUVR) system for amyloid PET images with 3D-MRI, and evaluate 
      its utility for detecting amyloid deposits in equivocal cases. METHODS: Of 126 
      subjects who underwent amyloid PET with (11)C-PiB and 3D-MRI, the area of 
      amyloid-positive regions and the critical regional GMSUVR thresholds were first 
      determined in 15 amyloid-positive and 15 amyloid-negative patients, using the 
      automatic volumetric measurement of segmented brain images system. We then tested 
      36 amyloid-negative, 60 amyloid-positive, and 13 equivocal subjects with this 
      GMSUVR system and with conventional mcSUVR. RESULTS: Sensitivity, specificity, 
      accuracy, positive predictive value (PPV) and negative predictive value (NPV) 
      were 100%, 92%, 97%, 95%, and 100% for the GMSUVR system; and 97%, 86%, 93%, 92% 
      and 94%, respectively, for mcSUVR. In 24 cases in which the findings were 
      equivocal or discordant, the sensitivity, specificity, accuracy, PPV, and NPV 
      were all 100% for the GMSUVR system; and were 90%, 33%, 83%, 90%, and 33%, 
      respectively, for mcSUVR. CONCLUSION: The regional GMSUVR measurement method was 
      well able to discriminate between amyloid-positive and -negative subjects, even 
      in cases where amyloid deposition was equivocal.
FAU - Ishii, Kazunari
AU  - Ishii K
AUID- ORCID: 0000-0001-6601-952X
AD  - Department of Radiology, Kindai University Faculty of Medicine, 377-2 
      Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan. ishii@med.kindai.ac.jp.
AD  - Institute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 
      Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan. ishii@med.kindai.ac.jp.
AD  - Neurocognitive Disorders Center, Kindai University Hospital, 377-2 Ohnohigashi, 
      Osaka-Sayama, Osaka, 589-8511, Japan. ishii@med.kindai.ac.jp.
FAU - Yamada, Takahiro
AU  - Yamada T
AD  - Institute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 
      Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
FAU - Hanaoka, Kohei
AU  - Hanaoka K
AD  - Institute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 
      Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
FAU - Kaida, Hayato
AU  - Kaida H
AD  - Department of Radiology, Kindai University Faculty of Medicine, 377-2 
      Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
AD  - Institute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 
      Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
FAU - Miyazaki, Koichi
AU  - Miyazaki K
AD  - Department of Radiology, Kindai University Faculty of Medicine, 377-2 
      Ohnohigashi, Osaka-Sayama, Osaka, 589-8511, Japan.
FAU - Ueda, Masami
AU  - Ueda M
AD  - Neurocognitive Disorders Center, Kindai University Hospital, 377-2 Ohnohigashi, 
      Osaka-Sayama, Osaka, 589-8511, Japan.
FAU - Hanada, Kazushi
AU  - Hanada K
AD  - Neurocognitive Disorders Center, Kindai University Hospital, 377-2 Ohnohigashi, 
      Osaka-Sayama, Osaka, 589-8511, Japan.
FAU - Saigoh, Kazumasa
AU  - Saigoh K
AD  - Neurocognitive Disorders Center, Kindai University Hospital, 377-2 Ohnohigashi, 
      Osaka-Sayama, Osaka, 589-8511, Japan.
FAU - Sauerbeck, Julia
AU  - Sauerbeck J
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, 
      Marchioninistr. 15, 81377, Munich, Germany.
FAU - Rominger, Axel
AU  - Rominger A
AD  - Inselspital, University Hospital Bern, University Clinic for Nuclear Medicine, 
      Freiburgstrasse 18, 3010, Bern, Switzerland.
FAU - Bartenstein, Peter
AU  - Bartenstein P
AD  - Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, 
      Marchioninistr. 15, 81377, Munich, Germany.
FAU - Kimura, Yuichi
AU  - Kimura Y
AD  - Graduate School of Biology-Oriented Science and Technology, Kindai University, 
      930 Nishimitani, Kinokawa City, Wakayama, 649-6493, Japan.
LA  - eng
GR  - 50534103/Japan Society for the Promotion of Science/
GR  - KD201804/Kindai University/
PT  - Journal Article
DEP - 20200827
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0 (Amyloid)
SB  - IM
MH  - Aged
MH  - Amyloid/*metabolism
MH  - Biological Transport
MH  - Female
MH  - Gray Matter/*diagnostic imaging/*metabolism
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography
OTO - NOTNLM
OT  - 11C-PiB PET
OT  - Alzheimer's disease
OT  - Amyloid
OT  - Equivocal accumulation
OT  - MRI
EDAT- 2020/08/28 06:00
MHDA- 2021/08/24 06:00
CRDT- 2020/08/28 06:00
PHST- 2020/07/12 00:00 [received]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2020/08/28 06:00 [entrez]
AID - 10.1007/s12149-020-01513-3 [pii]
AID - 10.1007/s12149-020-01513-3 [doi]
PST - ppublish
SO  - Ann Nucl Med. 2020 Nov;34(11):856-863. doi: 10.1007/s12149-020-01513-3. Epub 2020 
      Aug 27.