PMID- 32854033
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210110
IS  - 1936-5233 (Print)
IS  - 1936-5233 (Electronic)
IS  - 1936-5233 (Linking)
VI  - 13
IP  - 12
DP  - 2020 Dec
TI  - Searching for the real function of mTOR signaling in the regulation of PD-L1 
      expression.
PG  - 100847
LID - S1936-5233(20)30339-9 [pii]
LID - 10.1016/j.tranon.2020.100847 [doi]
LID - 100847
AB  - The mammalian target of rapamycin (mTOR), via forming two important complexes: 
      mTOR complex 1 (mTORC1) and complex 2 (mTORC2), plays an important role in the 
      regulation of immunity in addition to exerting many other biological funcions. 
      Beyond its regulatory effects on immune cells, the mTOR axis also regulates the 
      expression of programmed death-ligand 1 (PD-L1) in cancer cells; accordingly, 
      inhibition of mTOR alters PD-L1 levels in different cancer cell types. However, 
      the currently published studies on mTOR inhibition-induced PD-L1 alteration have 
      generated conflicting results. This review will focus on summarizing current 
      findings in this regard and discussing possible reasons for the discrepancies and 
      their potential implications for PD-L1 modulation in cancer therapy.
CI  - Copyright (c) 2020 The Author. Published by Elsevier Inc. All rights reserved.
FAU - Sun, Shi-Yong
AU  - Sun SY
AD  - Department of Hematology and Medical Oncology, Emory University of School of 
      Medicine, Winship Cancer Institute of Emory University, Atlanta, GA, United 
      States of America. Electronic address: ssun@emory.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200824
PL  - United States
TA  - Transl Oncol
JT  - Translational oncology
JID - 101472619
PMC - PMC7451686
OTO - NOTNLM
OT  - Cancer
OT  - PD-L1
OT  - Rapalogs
OT  - mTOR
OT  - mTORC1
OT  - p70S6K
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/08/28 06:00
MHDA- 2020/08/28 06:01
PMCR- 2020/08/24
CRDT- 2020/08/28 06:00
PHST- 2020/06/18 00:00 [received]
PHST- 2020/07/17 00:00 [revised]
PHST- 2020/08/04 00:00 [accepted]
PHST- 2020/08/28 06:00 [pubmed]
PHST- 2020/08/28 06:01 [medline]
PHST- 2020/08/28 06:00 [entrez]
PHST- 2020/08/24 00:00 [pmc-release]
AID - S1936-5233(20)30339-9 [pii]
AID - 100847 [pii]
AID - 10.1016/j.tranon.2020.100847 [doi]
PST - ppublish
SO  - Transl Oncol. 2020 Dec;13(12):100847. doi: 10.1016/j.tranon.2020.100847. Epub 
      2020 Aug 24.