PMID- 32854196
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201020
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 10
IP  - 9
DP  - 2020 Aug 25
TI  - Hyperpolarized (129)Xe Time-of-Flight MR Imaging of Perfusion and Brain Function.
LID - 10.3390/diagnostics10090630 [doi]
LID - 630
AB  - Perfusion measurements can provide vital information about the homeostasis of an 
      organ and can therefore be used as biomarkers to diagnose a variety of 
      cardiovascular, renal, and neurological diseases. Currently, the most common 
      techniques to measure perfusion are (15)O positron emission tomography (PET), 
      xenon-enhanced computed tomography (CT), single photon emission computed 
      tomography (SPECT), dynamic contrast enhanced (DCE) MRI, and arterial spin 
      labeling (ASL) MRI. Here, we show how regional perfusion can be quantitively 
      measured with magnetic resonance imaging (MRI) using time-resolved depolarization 
      of hyperpolarized (HP) xenon-129 ((129)Xe), and the application of this approach 
      to detect changes in cerebral blood flow (CBF) due to a hemodynamic response in 
      response to brain stimuli. The investigated HP (129)Xe Time-of-Flight (TOF) 
      technique produced perfusion images with an average signal-to-noise ratio (SNR) 
      of 10.35. Furthermore, to our knowledge, the first hemodynamic response (HDR) map 
      was acquired in healthy volunteers using the HP (129)Xe TOF imaging. Responses to 
      visual and motor stimuli were observed. The acquired HP TOF HDR maps correlated 
      well with traditional proton blood oxygenation level-dependent functional MRI. 
      Overall, this study expands the field of HP MRI with a novel dynamic imaging 
      technique suitable for rapid and quantitative perfusion imaging.
FAU - Shepelytskyi, Yurii
AU  - Shepelytskyi Y
AUID- ORCID: 0000-0001-5526-7958
AD  - Chemistry and Materials Science Program, Lakehead University, 955 Oliver Rd., 
      Thunder Bay, ON P7B 5E1, Canada.
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Rd., Thunder Bay, ON 
      P7B 5E1, Canada.
FAU - Hane, Francis T
AU  - Hane FT
AUID- ORCID: 0000-0002-2738-584X
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Rd., Thunder Bay, ON 
      P7B 5E1, Canada.
AD  - Chemistry Department, Lakehead University, 955 Oliver Rd., Thunder Bay, ON P7B 
      5E1, Canada.
FAU - Grynko, Vira
AU  - Grynko V
AUID- ORCID: 0000-0002-9580-0072
AD  - Chemistry and Materials Science Program, Lakehead University, 955 Oliver Rd., 
      Thunder Bay, ON P7B 5E1, Canada.
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Rd., Thunder Bay, ON 
      P7B 5E1, Canada.
FAU - Li, Tao
AU  - Li T
AD  - Chemistry Department, Lakehead University, 955 Oliver Rd., Thunder Bay, ON P7B 
      5E1, Canada.
FAU - Hassan, Ayman
AU  - Hassan A
AD  - Thunder Bay Regional Health Sciences Centre, 980 Oliver Rd., Thunder Bay, ON P7B 
      6V4, Canada.
AD  - Northern Ontario School of Medicine, 955 Oliver Rd., Thunder Bay, ON P7B 5E1, 
      Canada.
FAU - Albert, Mitchell S
AU  - Albert MS
AD  - Thunder Bay Regional Health Research Institute, 980 Oliver Rd., Thunder Bay, ON 
      P7B 5E1, Canada.
AD  - Chemistry Department, Lakehead University, 955 Oliver Rd., Thunder Bay, ON P7B 
      5E1, Canada.
AD  - Northern Ontario School of Medicine, 955 Oliver Rd., Thunder Bay, ON P7B 5E1, 
      Canada.
LA  - eng
GR  - ORF RE 09 029/Ontario Research Foundation/
GR  - A-18-05/Northern Ontario Academic Medicine Association/
PT  - Journal Article
DEP - 20200825
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC7554935
OTO - NOTNLM
OT  - fMRI
OT  - hemodynamic response
OT  - hyperpolarized 129Xe
OT  - hyperpolarized time-of-flight MRI
OT  - perfusion imaging
COIS- The authors declare no conflict of interest.
EDAT- 2020/08/29 06:00
MHDA- 2020/08/29 06:01
PMCR- 2020/08/25
CRDT- 2020/08/29 06:00
PHST- 2020/08/11 00:00 [received]
PHST- 2020/08/22 00:00 [revised]
PHST- 2020/08/23 00:00 [accepted]
PHST- 2020/08/29 06:00 [entrez]
PHST- 2020/08/29 06:00 [pubmed]
PHST- 2020/08/29 06:01 [medline]
PHST- 2020/08/25 00:00 [pmc-release]
AID - diagnostics10090630 [pii]
AID - diagnostics-10-00630 [pii]
AID - 10.3390/diagnostics10090630 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2020 Aug 25;10(9):630. doi: 10.3390/diagnostics10090630.