PMID- 32854851
OWN - NLM
STAT- MEDLINE
DCOM- 20211011
LR  - 20211204
IS  - 2162-5514 (Electronic)
IS  - 0074-7742 (Print)
IS  - 0074-7742 (Linking)
VI  - 155
DP  - 2020
TI  - Dysregulation of metabolic flexibility: The impact of mTOR on autophagy in 
      neurodegenerative disease.
PG  - 1-35
LID - S0074-7742(20)30009-X [pii]
LID - 10.1016/bs.irn.2020.01.009 [doi]
AB  - Non-communicable diseases (NCDs) that involve neurodegenerative disorders and 
      metabolic disease impact over 400 million individuals globally. Interestingly, 
      metabolic disorders, such as diabetes mellitus, are significant risk factors for 
      the development of neurodegenerative diseases. Given that current therapies for 
      these NCDs address symptomatic care, new avenues of discovery are required to 
      offer treatments that affect disease progression. Innovative strategies that fill 
      this void involve the mechanistic target of rapamycin (mTOR) and its associated 
      pathways of mTOR complex 1 (mTORC1), mTOR complex 2 (mTORC2), AMP activated 
      protein kinase (AMPK), trophic factors that include erythropoietin (EPO), and the 
      programmed cell death pathways of autophagy and apoptosis. These pathways are 
      intriguing in their potential to provide effective care for metabolic and 
      neurodegenerative disorders. Yet, future work is necessary to fully comprehend 
      the entire breadth of the mTOR pathways that can effectively and safely translate 
      treatments to clinical medicine without the development of unexpected clinical 
      disabilities.
CI  - (c) 2020 Elsevier Inc. All rights reserved.
FAU - Maiese, Kenneth
AU  - Maiese K
AD  - Cellular and Molecular Signaling, New York, NY, United States. Electronic 
      address: wntin75@yahoo.com.
LA  - eng
GR  - R01 NS053946/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200811
PL  - United States
TA  - Int Rev Neurobiol
JT  - International review of neurobiology
JID - 0374740
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Apoptosis/genetics
MH  - Autophagy/*genetics
MH  - Humans
MH  - Middle Aged
MH  - Neurodegenerative Diseases/*genetics/*metabolism
MH  - Noncommunicable Diseases/epidemiology
MH  - TOR Serine-Threonine Kinases/*genetics/*metabolism
PMC - PMC7457955
MID - NIHMS1590143
OTO - NOTNLM
OT  - AMPK
OT  - Alzheimer's disease
OT  - Apoptosis
OT  - Autophagy
OT  - Dementia
OT  - Diabetes mellitus
OT  - Erythropoietin
OT  - mTOR
OT  - mTORC1
OT  - mTORC2
EDAT- 2020/08/29 06:00
MHDA- 2021/10/12 06:00
PMCR- 2020/08/31
CRDT- 2020/08/29 06:00
PHST- 2020/08/29 06:00 [entrez]
PHST- 2020/08/29 06:00 [pubmed]
PHST- 2021/10/12 06:00 [medline]
PHST- 2020/08/31 00:00 [pmc-release]
AID - S0074-7742(20)30009-X [pii]
AID - 10.1016/bs.irn.2020.01.009 [doi]
PST - ppublish
SO  - Int Rev Neurobiol. 2020;155:1-35. doi: 10.1016/bs.irn.2020.01.009. Epub 2020 Aug 
      11.