PMID- 32854856
OWN - NLM
STAT- MEDLINE
DCOM- 20211011
LR  - 20211011
IS  - 2162-5514 (Electronic)
IS  - 0074-7742 (Print)
IS  - 0074-7742 (Linking)
VI  - 155
DP  - 2020
TI  - Harnessing neurogenesis in the adult brain-A role in type 2 diabetes mellitus and 
      Alzheimer's disease.
PG  - 235-269
LID - S0074-7742(20)30051-9 [pii]
LID - 10.1016/bs.irn.2020.03.020 [doi]
AB  - Some metabolic disorders, such as type 2 diabetes mellitus (T2DM) are risk 
      factors for the development of cognitive deficits and Alzheimer's disease (AD). 
      Epidemiological studies suggest that in people with T2DM, the risk of developing 
      dementia is 2.5 times higher than that in the non-diabetic population. The 
      signaling pathways that underlie the increased risk and facilitate cognitive 
      deficits are not fully understood. In fact, the cause of memory deficits in AD is 
      not fully elucidated. The dentate gyrus of the hippocampus plays an important 
      role in memory formation. Hippocampal neurogenesis is the generation of new 
      neurons and glia in the adult brain throughout life. New neurons incorporate in 
      the granular cell layer of the dentate gyrus and play a role in learning and 
      memory and hippocampal plasticity. A large body of studies suggests that 
      hippocampal neurogenesis is impaired in mouse models of AD and T2DM. Recent 
      evidence shows that hippocampal neurogenesis is also impaired in human patients 
      exhibiting mild cognitive impairment or AD. This review discusses the role of 
      hippocampal neurogenesis in the development of cognitive deficits and AD, and 
      considers inflammatory and endothelial signaling pathways in T2DM that may 
      compromise hippocampal neurogenesis and cognitive function, leading to AD.
CI  - (c) 2020 Elsevier Inc. All rights reserved.
FAU - Lazarov, Orly
AU  - Lazarov O
AD  - Department of Anatomy and Cell Biology, The University of Illinois at Chicago, 
      Chicago, IL, United States. Electronic address: olazarov@uic.edu.
FAU - Minshall, Richard D
AU  - Minshall RD
AD  - Department of Pharmacology, The University of Illinois at Chicago, Chicago, IL, 
      United States; Department of Anesthesiology, The University of Illinois at 
      Chicago, Chicago, IL, United States.
FAU - Bonini, Marcelo G
AU  - Bonini MG
AD  - Department of Medicine (Hematology/Oncology), Feinberg School of Medicine of 
      Northwestern University and Basic Sciences Research, Robert H. Lurie 
      Comprehensive Cancer Centre, Chicago, IL, United States.
LA  - eng
GR  - R01 AG033570/AG/NIA NIH HHS/United States
GR  - R01 AG060238/AG/NIA NIH HHS/United States
GR  - R01 AG062251/AG/NIA NIH HHS/United States
GR  - R21 AG061628/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Int Rev Neurobiol
JT  - International review of neurobiology
JID - 0374740
SB  - IM
MH  - Alzheimer Disease/pathology/*therapy
MH  - Animals
MH  - Diabetes Mellitus, Type 2/pathology/*therapy
MH  - Hippocampus/pathology
MH  - Humans
MH  - Inflammation/pathology
MH  - *Neurogenesis
MH  - Neurovascular Coupling
PMC - PMC7687300
MID - NIHMS1647579
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Caveolin-1
OT  - Cerebrovasculature
OT  - Cognition
OT  - Diabetes
OT  - Endothelial function
OT  - Hippocampal neurogenesis
EDAT- 2020/08/29 06:00
MHDA- 2021/10/12 06:00
PMCR- 2020/11/25
CRDT- 2020/08/29 06:00
PHST- 2020/08/29 06:00 [entrez]
PHST- 2020/08/29 06:00 [pubmed]
PHST- 2021/10/12 06:00 [medline]
PHST- 2020/11/25 00:00 [pmc-release]
AID - S0074-7742(20)30051-9 [pii]
AID - 10.1016/bs.irn.2020.03.020 [doi]
PST - ppublish
SO  - Int Rev Neurobiol. 2020;155:235-269. doi: 10.1016/bs.irn.2020.03.020.