PMID- 32855992
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2328-8957 (Print)
IS  - 2328-8957 (Electronic)
IS  - 2328-8957 (Linking)
VI  - 7
IP  - 8
DP  - 2020 Aug
TI  - A Case of Steroid-Responsive, COVID-19 Immune Reconstitution Inflammatory 
      Syndrome Following the Use of Granulocyte Colony-Stimulating Factor.
PG  - ofaa326
LID - 10.1093/ofid/ofaa326 [doi]
LID - ofaa326
AB  - We present a case report of a 54-year-old male with metastasized nasopharyngeal 
      carcinoma presenting to the hospital with dyspnea, anorexia and fever. 
      Examination revealed chemotherapy-induced pancytopenia. The patient tested 
      positive for SARSCoV-2, but respiratory complications were mild. The patient was 
      treated with granulocyte-colony stimulating factor (G-CSF) leading to 
      amelioration of the neutropenia. However, severe acute respiratory distress 
      syndrome (ARDS) occurred, prompting the diagnosis of immune reconstitution 
      inflammatory syndrome (IRIS). GCSF is currently investigated as additional 
      therapy in ARDS, but this case report emphasizes that risks and benefits must be 
      carefully assessed. To our knowledge, this is the first case report of 
      IRIS-induced ARDS in a COVID-19 patient.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of 
      Infectious Diseases Society of America.
FAU - Mertens, Jonathan
AU  - Mertens J
AUID- ORCID: 0000-0002-4822-4113
AD  - Department of Internal Medicine, University Hospital Antwerp, Antwerp, Belgium.
FAU - Laghrib, Yassine
AU  - Laghrib Y
AD  - Department of Internal Medicine, University Hospital Antwerp, Antwerp, Belgium.
FAU - Kenyon, Chris
AU  - Kenyon C
AUID- ORCID: 0000-0001-9861-8033
AD  - HIV/STI Unit, Institute of Tropical Medicine, Department of Clinical Sciences, 
      Antwerp, Belgium.
AD  - Division of Infectious Diseases and HIV Medicine, University of Cape Town, 
      Observatory, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20200817
PL  - United States
TA  - Open Forum Infect Dis
JT  - Open forum infectious diseases
JID - 101637045
PMC - PMC7443106
OTO - NOTNLM
OT  - ARDS
OT  - COVID-19
OT  - IRIS
OT  - SARS-CoV-2
OT  - granulocyte-colony stimulating factor
OT  - immune reconstitution inflammatory syndrome
EDAT- 2020/08/29 06:00
MHDA- 2020/08/29 06:01
PMCR- 2020/08/17
CRDT- 2020/08/29 06:00
PHST- 2020/05/27 00:00 [received]
PHST- 2020/07/27 00:00 [accepted]
PHST- 2020/08/29 06:00 [entrez]
PHST- 2020/08/29 06:00 [pubmed]
PHST- 2020/08/29 06:01 [medline]
PHST- 2020/08/17 00:00 [pmc-release]
AID - ofaa326 [pii]
AID - 10.1093/ofid/ofaa326 [doi]
PST - epublish
SO  - Open Forum Infect Dis. 2020 Aug 17;7(8):ofaa326. doi: 10.1093/ofid/ofaa326. 
      eCollection 2020 Aug.