PMID- 32858087
OWN - NLM
STAT- MEDLINE
DCOM- 20220209
LR  - 20220209
IS  - 1879-0089 (Electronic)
IS  - 0145-305X (Linking)
VI  - 114
DP  - 2021 Jan
TI  - Epigenetic control of myeloid cells behavior by Histone Deacetylase activity 
      (HDAC) during tissue and organ regeneration in Xenopus laevis.
PG  - 103840
LID - S0145-305X(20)30395-5 [pii]
LID - 10.1016/j.dci.2020.103840 [doi]
AB  - In the present work we have focused on the Histone Deacetylase (HDAC) control of 
      myeloid cells behavior during Xenopus tail regeneration. Here we show that 
      myeloid differentiation is crucial to modulate the regenerative ability of 
      Xenopus tadpoles in a HDAC activity-dependent fashion. HDAC activity inhibition 
      during the first wave of myeloid differentiation disrupted myeloid cells dynamics 
      in the regenerative bud as well the mRNA expression pattern of myeloid markers, 
      such as LURP, MPOX, Spib and mmp7. We also functionally bridge the spatial and 
      temporal dynamics of lipid droplets, the main platform of lipid mediators 
      synthesis in myeloid cells during the inflammatory response, and the regenerative 
      ability of Xenopus tadpoles. In addition, we showed that 15-LOX activity is 
      necessary during tail regeneration. Taken together our results support a role for 
      the epigenetic control of myeloid behavior during tissue and organ regeneration, 
      which may positively impact translational approaches for regenerative medicine.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Pentagna, Nathalia
AU  - Pentagna N
AD  - Instituto de Ciencias Biomedicas, Universidade Federal Do Rio de Janeiro, Av. 
      Carlos Chagas Filho 373 Bloco F Sala F2-01, Rio de Janeiro, 21941-902, Brazil; 
      Programa de Pos-graduacao Em Medicina (Anatomia Patologica), Faculdade de 
      Medicina, Universidade Federal Do Rio de Janeiro, R. Prof. Rodolpho Paulo Rocco, 
      255, Rio de Janeiro, 21941-590, Brazil. Electronic address: natpires87@gmail.com.
FAU - Pinheiro da Costa, Thayse
AU  - Pinheiro da Costa T
AD  - Instituto de Ciencias Biomedicas, Universidade Federal Do Rio de Janeiro, Av. 
      Carlos Chagas Filho 373 Bloco F Sala F2-01, Rio de Janeiro, 21941-902, Brazil.
FAU - Soares Dos Santos Cardoso, Fellipe
AU  - Soares Dos Santos Cardoso F
AD  - Programa de Pos-graduacao Em Medicina (Anatomia Patologica), Faculdade de 
      Medicina, Universidade Federal Do Rio de Janeiro, R. Prof. Rodolpho Paulo Rocco, 
      255, Rio de Janeiro, 21941-590, Brazil. Electronic address: 
      fellipekardoso@hotmail.com.
FAU - Martins de Almeida, Fernanda
AU  - Martins de Almeida F
AD  - Instituto de Ciencias Biomedicas, Universidade Federal Do Rio de Janeiro, Av. 
      Carlos Chagas Filho 373 Bloco F Sala F2-01, Rio de Janeiro, 21941-902, Brazil; 
      Programa de Pos-graduacao Em Medicina (Anatomia Patologica), Faculdade de 
      Medicina, Universidade Federal Do Rio de Janeiro, R. Prof. Rodolpho Paulo Rocco, 
      255, Rio de Janeiro, 21941-590, Brazil. Electronic address: 
      fealmeida.maia@gmail.com.
FAU - Blanco Martinez, Ana Maria
AU  - Blanco Martinez AM
AD  - Programa de Pos-graduacao Em Medicina (Anatomia Patologica), Faculdade de 
      Medicina, Universidade Federal Do Rio de Janeiro, R. Prof. Rodolpho Paulo Rocco, 
      255, Rio de Janeiro, 21941-590, Brazil. Electronic address: 
      anamartinez@hucff.ufrj.br.
FAU - Abreu, Jose Garcia
AU  - Abreu JG
AD  - Instituto de Ciencias Biomedicas, Universidade Federal Do Rio de Janeiro, Av. 
      Carlos Chagas Filho 373 Bloco F Sala F2-01, Rio de Janeiro, 21941-902, Brazil. 
      Electronic address: garciajr@icb.ufrj.br.
FAU - Levin, Michael
AU  - Levin M
AD  - Allen Discovery Center, Tufts University, School of Arts and Science, Department 
      of Biology, Suite, 4600, Medford, MA, United States. Electronic address: 
      Michael.Levin@tufts.edu.
FAU - Carneiro, Katia
AU  - Carneiro K
AD  - Instituto de Ciencias Biomedicas, Universidade Federal Do Rio de Janeiro, Av. 
      Carlos Chagas Filho 373 Bloco F Sala F2-01, Rio de Janeiro, 21941-902, Brazil; 
      Programa de Pos-graduacao Em Medicina (Anatomia Patologica), Faculdade de 
      Medicina, Universidade Federal Do Rio de Janeiro, R. Prof. Rodolpho Paulo Rocco, 
      255, Rio de Janeiro, 21941-590, Brazil. Electronic address: 
      kcarneiro@histo.ufrj.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200825
PL  - United States
TA  - Dev Comp Immunol
JT  - Developmental and comparative immunology
JID - 7708205
RN  - 0 (Biomarkers)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Epigenesis, Genetic
MH  - Gene Expression Regulation, Developmental
MH  - Histone Deacetylases/*metabolism
MH  - Humans
MH  - Myeloid Cells/*metabolism
MH  - Organogenesis
MH  - Regeneration
MH  - Regenerative Medicine
MH  - Xenopus laevis/*physiology
OTO - NOTNLM
OT  - Epigenetics
OT  - Histone deacetylase
OT  - Myeloid cells
OT  - Tissue and organ regeneration
OT  - Xenopus laevis tail
EDAT- 2020/08/29 06:00
MHDA- 2022/02/10 06:00
CRDT- 2020/08/29 06:00
PHST- 2020/05/09 00:00 [received]
PHST- 2020/08/18 00:00 [revised]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2020/08/29 06:00 [pubmed]
PHST- 2022/02/10 06:00 [medline]
PHST- 2020/08/29 06:00 [entrez]
AID - S0145-305X(20)30395-5 [pii]
AID - 10.1016/j.dci.2020.103840 [doi]
PST - ppublish
SO  - Dev Comp Immunol. 2021 Jan;114:103840. doi: 10.1016/j.dci.2020.103840. Epub 2020 
      Aug 25.