PMID- 32860359
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 1873-4251 (Electronic)
IS  - 1570-162X (Linking)
VI  - 19
IP  - 1
DP  - 2021
TI  - Prevalence of Asymptomatic Cryptococcal Antigenemia and Association with 
      Follow-up Risk of Cryptococcal Meningitis and Mortality among HIV Infected 
      Patients in North West India: A Prospective Cohort Study.
PG  - 35-39
LID - 10.2174/1570162X18666200827113816 [doi]
AB  - OBJECTIVE: Cryptococcal meningitis is an important cause of morbidity and 
      mortality in HIV infected individuals. In the era of universal antiretroviral 
      therapy, the incidence of immune reconstitution inflammatory syndrome (IRIS) 
      related cryptococcal meningitis has increased. Detection of serum cryptococcal 
      antigen in asymptomatic PLHIV (People Living With HIV) and preemptive treatment 
      with fluconazole can decrease the burden of cryptococcal disease. We conducted 
      this study to find the prevalence of asymptomatic cryptococcal antigenemia in 
      India and its correlation with mortality in PLHIV. METHOD AND MATERIALS: This was 
      a prospective observational study. HIV infected ART naive patients with age of >/= 
      18 years who had CD4 counts </= 100 /muL were included and serum cryptococcal 
      antigen test was done. These patients were followed for six months to look for 
      the development of Cryptococcal meningitis and mortality. RESULTS: A total of 116 
      patients were analyzed. Asymptomatic cryptococcal antigenemia was detected in 
      5.17% of patients and is correlated with increased risk of cryptococcal 
      meningitis and mortality on follow-up in PLHIV. CONCLUSION: Serum cryptococcal 
      antigen positivity is correlated with an increased risk of Cryptococcal 
      meningitis and mortality in PLHIV. We recommend the screening of asymptomatic 
      PLHIV with CD4 </= 100/muL for serum cryptococcal antigen, so that pre-emptive 
      treatment can be initiated to reduce morbidity and mortality.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Bhati, Rajendra
AU  - Bhati R
AD  - Department of Medicine, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
FAU - Pramendra, Sirohi
AU  - Pramendra S
AD  - Department of Medicine, S.P. Medical College, Bikaner, India.
FAU - Sejoo, Bharat
AU  - Sejoo B
AD  - Department of Medicine, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
FAU - Kumar, Deepak
AU  - Kumar D
AD  - Department of Medicine, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
FAU - Bohra, Gopal K
AU  - Bohra GK
AD  - Department of Medicine, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
FAU - Meena, Durga S
AU  - Meena DS
AD  - Department of Medicine, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
FAU - Verma, Diwakar
AU  - Verma D
AD  - Department of Emergency Medicine, All India Institute of Medical Sciences, 
      Jodhpur, Rajasthan, India.
FAU - Midha, Naresh K
AU  - Midha NK
AD  - Department of Medicine, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Netherlands
TA  - Curr HIV Res
JT  - Current HIV research
JID - 101156990
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*drug therapy/epidemiology/*etiology
MH  - Adult
MH  - Asymptomatic Diseases/epidemiology
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/*complications/*drug therapy/epidemiology/*mortality
MH  - Humans
MH  - Incidence
MH  - India/epidemiology
MH  - Male
MH  - Meningitis, Cryptococcal/*drug therapy/epidemiology/*etiology/*mortality
MH  - Middle Aged
MH  - Prevalence
MH  - Prospective Studies
MH  - Risk Assessment
OTO - NOTNLM
OT  - CD4 counts
OT  - Cryptococcal meningitis
OT  - HIV infection
OT  - antiretroviral therapy
OT  - asymptomatic cryptococcal antigenemia
OT  - serum cryptococcal antigen
EDAT- 2020/08/30 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/08/30 06:00
PHST- 2020/04/10 00:00 [received]
PHST- 2020/07/17 00:00 [revised]
PHST- 2020/08/05 00:00 [accepted]
PHST- 2020/08/30 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/08/30 06:00 [entrez]
AID - CHR-EPUB-109519 [pii]
AID - 10.2174/1570162X18666200827113816 [doi]
PST - ppublish
SO  - Curr HIV Res. 2021;19(1):35-39. doi: 10.2174/1570162X18666200827113816.