PMID- 32861382
OWN - NLM
STAT- MEDLINE
DCOM- 20210331
LR  - 20210331
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 72
IP  - 4
DP  - 2020 Jul-Aug
TI  - Etiology and distribution of isolated aortic stenosis in Indian patients - A 
      study from a large tertiary care hospital in north India.
PG  - 272-277
LID - S0019-4832(20)30141-3 [pii]
LID - 10.1016/j.ihj.2020.06.013 [doi]
AB  - BACKGROUND: Isolated aortic valve disease (IAVD) has traditionally been a disease 
      of elderly, etiology being either senile degeneration of a tricuspid aortic valve 
      or calcification of a bicuspid aortic valve. However, there is scarcity of Indian 
      data regarding demographic distribution and etiological patterns of IAVD in 
      context of emerging therapies like transcatheter aortic valve implantation 
      (TAVR). METHODS & RESULTS: A retrospective observational analysis of 60,560 
      echocardiograms over three years revealed 3728 newly diagnosed cases of valvular 
      heart disease (VHD). Isolated mitral valve disease (IMVD) constituted 48.7% 
      (n = 1815) of all VHD, including 1104 (29.6%) cases of pure mitral stenosis (MS) 
      which was the commonest single lesion followed by combined mitral and aortic 
      valve disease (CMAVD) (n = 1320, 34.5%), mixed aortic valve disease (MAVD) 
      (n = 349, 9.4%), isolated aortic stenosis (IAS) (n = 179, 4.8%) and isolated 
      aortic regurgitation (IAR) (n = 75, 2.0%). IAS patients had bimodal age 
      distribution with peaks in first and sixth decade, contributed by congenital and 
      acquired IAS respectively. Acquired IAS comprised of degenerative tricuspid 
      aortic valve (n = 79, 58.1%; mean age: 63.2 +/- 8.8 years), bicuspid aortic valve 
      (BAV) (n = 34, 25.0%; mean age: 36.0 +/- 8.3 years), rheumatic (n = 4, 2.9%; mean 
      age: 55.3 +/- 3.4 years) and non-rheumatic IAS with unclear morphology (n = 19, 
      14%; mean age: 48.5 +/- 9.3 years). 65.6% patients with acquired non-rheumatic 
      isolated aortic stenosis were less than 60 years of age. CONCLUSION: In Indian 
      population, senile valvular degeneration is the commonest cause of acquired IAS 
      with majority of them presenting before 60 years of age, thereby bereaving them 
      with the option of TAVR as a treatment modality.
CI  - Copyright (c) 2020 Cardiological Society of India. Published by Elsevier B.V. All 
      rights reserved.
FAU - Sahu, Ankit Kumar
AU  - Sahu AK
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India.
FAU - Sagar, Pramod
AU  - Sagar P
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India.
FAU - Khanna, Roopali
AU  - Khanna R
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India.
FAU - Kumar, Sudeep
AU  - Kumar S
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India.
FAU - Tewari, Satyendra
AU  - Tewari S
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India.
FAU - Kapoor, Aditya
AU  - Kapoor A
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India.
FAU - Garg, Naveen
AU  - Garg N
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India.
FAU - Goel, Pravin K
AU  - Goel PK
AD  - Department of Cardiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences (SGPGIMS), Lucknow, 226014, Uttar Pradesh, India. Electronic address: 
      golf_pgi@yahoo.co.in.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20200629
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve/*diagnostic imaging/surgery
MH  - Aortic Valve Stenosis/epidemiology/*etiology/surgery
MH  - Child
MH  - Echocardiography/*methods
MH  - Female
MH  - Humans
MH  - Incidence
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tertiary Care Centers/*statistics & numerical data
MH  - Transcatheter Aortic Valve Replacement/*methods
MH  - Young Adult
PMC - PMC7474108
OTO - NOTNLM
OT  - Acquired degenerative aortic stenosis
OT  - Isolated aortic valve stenosis
OT  - Transcatheter aortic valve replacement
OT  - Valvular heart disease
COIS- Declaration of Competing Interest All authors have none to declare.
EDAT- 2020/08/31 06:00
MHDA- 2021/04/01 06:00
PMCR- 2020/07/01
CRDT- 2020/08/31 06:00
PHST- 2020/04/08 00:00 [received]
PHST- 2020/05/29 00:00 [revised]
PHST- 2020/06/21 00:00 [accepted]
PHST- 2020/08/31 06:00 [entrez]
PHST- 2020/08/31 06:00 [pubmed]
PHST- 2021/04/01 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - S0019-4832(20)30141-3 [pii]
AID - 10.1016/j.ihj.2020.06.013 [doi]
PST - ppublish
SO  - Indian Heart J. 2020 Jul-Aug;72(4):272-277. doi: 10.1016/j.ihj.2020.06.013. Epub 
      2020 Jun 29.