PMID- 32862657 OWN - NLM STAT- MEDLINE DCOM- 20210730 LR - 20211203 IS - 1931-8405 (Electronic) IS - 0889-2229 (Print) IS - 0889-2229 (Linking) VI - 36 IP - 12 DP - 2020 Dec TI - Short Communication: Carotid Artery Plaque Burden in HIV Is Associated with Soluble Mediators and Monocytes. PG - 1020-1023 LID - 10.1089/AID.2020.0075 [doi] AB - Maximum carotid plaque thickness (MCPT) measures the largest plaque thickness in the carotid artery and reflects atherosclerosis plaque burden. MCPT may be a better predictor of cardiovascular disease than carotid artery intima-media thickness (cIMT) because it identifies potential unstable arterial atherosclerosis plaques. We assessed the relationships of monocyte and T cell populations and plasma soluble mediators with MCPT measures. We performed a cross-sectional and small follow-up analysis in people living with HIV (PLWH) aged >40 years on stable antiretroviral therapy (ART) >6 months. MCPT was acquired by high-resolution B-mode ultrasound. Existing monocyte subsets and T cell activation frequencies were determined by flow cytometry and plasma mediators of inflammation and apolipoproteins were measured by Luminex assay. One hundred twenty-five ART-treated PLWH, 88% male, 55% Caucasian, with a median age of 51 years, median CD4 count of 477 cells/muL (Q1: 325, Q3: 612), 84% undetectable plasma HIV RNA (<50 copies/mL). Twenty-five PLWH had detectable carotid plaque. MCPT correlated with monocyte chemoattractant protein-1 (MCP-1; r = 0.487, p = .016), tumor necrosis factor-alpha (TNF-alpha; r = 0.474 p = .019), soluble vascular cell adhesion molecule-1 (sVCAM-1; r = 0.472, p = .020), apolipoprotein B6 (ApoB6; r = -0.473, p = .019), and interleukin-6 (IL-6; r = 0.455, p = .025). In a multivariable regression model, MCP-1, TNF-alpha, and sVCAM-1 remained significant after adjustment for age. Carotid plaque burden was associated with increased inflammatory, monocyte, and endothelial measures, including MCP-1, TNF-alpha, and sVCAM-1 levels. Further investigation on the evolution or severity of plaque burden in this population is warranted. FAU - Chow, Dominic C AU - Chow DC AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - Mau, Makoa AU - Mau M AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - Hodis, Howard N AU - Hodis HN AD - Atherosclerosis Research Unit, University of Southern California, Los Angeles, California, USA. FAU - Kewcharoen, Jakrin AU - Kewcharoen J AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - Li, Yanjie AU - Li Y AD - Atherosclerosis Research Unit, University of Southern California, Los Angeles, California, USA. FAU - Siriwardhana, Chathura AU - Siriwardhana C AD - Department of Tropical Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - Souza, Scott A AU - Souza SA AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. AD - Queen's Medical Center, Honolulu, Hawai'i, USA. FAU - Mitchell, Brooks I AU - Mitchell BI AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - Bowler, Scott AU - Bowler S AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - SahBandar, Ivo AU - SahBandar I AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. AD - Department of Tropical Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. AD - Weill Cornell Medicine, New York, New York, USA. FAU - Gangcuangco, Louie Mar A AU - Gangcuangco LMA AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - MacPherson, Iain AU - MacPherson I AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. FAU - Ndhlovu, Lishomwa C AU - Ndhlovu LC AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. AD - Department of Tropical Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. AD - Weill Cornell Medicine, New York, New York, USA. FAU - Shikuma, Cecilia M AU - Shikuma CM AD - Hawai'i Center for AIDS, Department of Medicine, University of Hawai'i, John A. Burns School of Medicine, Honolulu, Hawai'i, USA. LA - eng GR - U54 MD007584/MD/NIMHD NIH HHS/United States GR - U54 MD007601/MD/NIMHD NIH HHS/United States GR - R01 HL095135/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20200928 PL - United States TA - AIDS Res Hum Retroviruses JT - AIDS research and human retroviruses JID - 8709376 SB - IM MH - *Carotid Artery Diseases MH - Carotid Intima-Media Thickness MH - *Carotid Stenosis MH - Cross-Sectional Studies MH - Female MH - *HIV Infections MH - Humans MH - Male MH - Middle Aged MH - Monocytes MH - Risk Factors PMC - PMC7703087 OTO - NOTNLM OT - maximum carotid plaque thickness OT - monocyte subsets OT - soluble mediators COIS- No competing financial interests exist. EDAT- 2020/08/31 06:00 MHDA- 2021/07/31 06:00 PMCR- 2021/12/01 CRDT- 2020/09/01 06:00 PHST- 2020/08/31 06:00 [pubmed] PHST- 2021/07/31 06:00 [medline] PHST- 2020/09/01 06:00 [entrez] PHST- 2021/12/01 00:00 [pmc-release] AID - 10.1089/aid.2020.0075 [pii] AID - 10.1089/AID.2020.0075 [doi] PST - ppublish SO - AIDS Res Hum Retroviruses. 2020 Dec;36(12):1020-1023. doi: 10.1089/AID.2020.0075. Epub 2020 Sep 28.