PMID- 32865007
OWN - NLM
STAT- MEDLINE
DCOM- 20201231
LR  - 20201231
IS  - 1522-1555 (Electronic)
IS  - 0193-1849 (Linking)
VI  - 319
IP  - 4
DP  - 2020 Oct 1
TI  - Physiological profile regulation during weight gain and loss by ovariectomized 
      females: importance of SIRT1 and SIRT4.
PG  - E769-E778
LID - 10.1152/ajpendo.00465.2019 [doi]
AB  - Obesity in menopausal women occurs because of the systemic effects of loss of 
      ovarian function, resulting in increased body weight and oxidative stress. 
      Caloric restriction (CR) is essential for weight loss, since it provides benefits 
      associated with metabolic normalization resulting from the action of sirtuins. 
      The aim of this work was to evaluate the physiological effects of weight cycling 
      in ovariectomized females. Females aged 2 mo (n = 8/group) were submitted to 
      simulated surgery, ovariectomy (OVX group), and ovariectomy with weight 
      fluctuation (WF group). In the WF group, weight cycling was performed two times, 
      using 21 days of ad libitum commercial feed and 21 days of caloric restriction 
      with 40% of the feed consumed by the OVX group. After 17 wk, the animals were 
      evaluated experimentally. Weight fluctuations reduced triacylglycerol and the 
      adipose tissue index of the WF animals, while increasing the expression of 
      antioxidant proteins. In addition to causing fluctuations in the physiological 
      parameters, the weight cycling led to increases of adipocyte number and serum 
      fatty acids. These effects were reflected in increased expression of the sirtuin 
      (SIRT) 1 and SIRT4 proteins, as well as protein complexes of the mitochondrial 
      electron transport chain, especially in the liver and adipose tissues. The 
      weight-cycling results suggested that mitochondrial and nuclear sirtuins were 
      active in cellular signaling for the control of lipid metabolism, oxidative 
      phosphorylation, and redox status. Weight cycling was able to restore the health 
      characteristics of lean animals.
FAU - Camargo, Thais Furtado
AU  - Camargo TF
AD  - Graduate Program in Biomedical Sciences, Centro Universitario Herminio Ometto, 
      FHO/UNIARARAS, Araras, Sau Paulo, Brazil.
FAU - Zanesco, Ariane Maria
AU  - Zanesco AM
AD  - College of Biomedicine, Centro Universitario Herminio Ometto, Araras, Sau Paulo, 
      Brazil.
FAU - Pacher, Kayo Augusto Salandin
AU  - Pacher KAS
AD  - Graduate Program in Biomedical Sciences, Centro Universitario Herminio Ometto, 
      FHO/UNIARARAS, Araras, Sau Paulo, Brazil.
FAU - Andrade, Thiago Antonio Moretti
AU  - Andrade TAM
AD  - Graduate Program in Biomedical Sciences, Centro Universitario Herminio Ometto, 
      FHO/UNIARARAS, Araras, Sau Paulo, Brazil.
FAU - Alves, Armindo Antonio
AU  - Alves AA
AD  - Centro Universitario Herminio Ometto, Araras, Sau Paulo, Brazil.
FAU - do Amaral, Maria Esmeria Corezola
AU  - do Amaral MEC
AD  - Graduate Program in Biomedical Sciences, Centro Universitario Herminio Ometto, 
      FHO/UNIARARAS, Araras, Sau Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200831
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Antioxidants)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Triglycerides)
RN  - EC 3.5.1.- (Sirt1 protein, rat)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Adipocytes
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Caloric Restriction
MH  - Eating
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Lipid Metabolism/genetics
MH  - *Ovariectomy
MH  - Rats
MH  - Rats, Wistar
MH  - Sirtuin 1/genetics/*physiology
MH  - Triglycerides/metabolism
MH  - Weight Gain/*physiology
MH  - Weight Loss/*physiology
OTO - NOTNLM
OT  - ovariectomized
OT  - oxidative phosphorylation
OT  - restricted diet
OT  - sirtuins
OT  - weight cycle
EDAT- 2020/09/01 06:00
MHDA- 2021/01/01 06:00
CRDT- 2020/09/01 06:00
PHST- 2020/09/01 06:00 [pubmed]
PHST- 2021/01/01 06:00 [medline]
PHST- 2020/09/01 06:00 [entrez]
AID - 10.1152/ajpendo.00465.2019 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E769-E778. doi: 
      10.1152/ajpendo.00465.2019. Epub 2020 Aug 31.