PMID- 32865181
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20210805
IS  - 1875-8592 (Electronic)
IS  - 1574-0153 (Linking)
VI  - 29
IP  - 4
DP  - 2020
TI  - Interferon-induced transmembrane protein 1 (IFITM1) is essential for progression 
      of laryngeal squamous cell carcinoma in an Osteopontin/NF-kappaB-dependent manner.
PG  - 521-529
LID - 10.3233/CBM-201435 [doi]
AB  - OBJECTIVE: To assess the expression levels of IFITM1 in human tissue samples and 
      laryngeal squamous cell carcinoma (LSCC) cells, and to explore the potential 
      mechanisms of IFITM1 in LSCC progression. METHODS: Quantitative PCR and 
      immunohistochemical (IHC) assays were performed to detect IFITM1 expression in 62 
      LSCC tissues and corresponding normal tissues. We further detected the effects of 
      IFITM1 on the proliferation, migration and invasion of LSCC cells and NF-kappaB 
      signaling pathway through colony formation assay, wound healing assay and 
      transwell assay, respectively. RESULTS: We demonstrated the possible involvement 
      of IFITM1 in the progression of LSCC. We found the upregulated expression of 
      IFITM1 in human LSCC tissues and cells, and analyzed the correlations between 
      IFITM1 expression and osteopontin. Our data further confirmed that IFITM1 
      affected cell proliferation, migration, and invasion of LSCC cells via the 
      regulation of NF-kappaB signaling pathway. CONCLUSIONS: We investigated the potential 
      involvement of IFITM1 in the progression of LSCC, and therefore confirmed that 
      IFITM1 was a potential therapeutic target for LSCC.
FAU - Yin, Yong
AU  - Yin Y
FAU - Yang, Keke
AU  - Yang K
FAU - Li, Juanjuan
AU  - Li J
FAU - Da, Peng
AU  - Da P
FAU - Zhang, Zhenxin
AU  - Zhang Z
FAU - Qiu, Xiaoxia
AU  - Qiu X
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Cancer Biomark
JT  - Cancer biomarkers : section A of Disease markers
JID - 101256509
RN  - 0 (Antigens, Differentiation)
RN  - 0 (NF-kappa B)
RN  - 0 (leu-13 antigen)
RN  - 106441-73-0 (Osteopontin)
SB  - IM
MH  - Antigens, Differentiation/biosynthesis/genetics/*metabolism
MH  - Cell Line, Tumor
MH  - Cell Movement/physiology
MH  - Cell Proliferation/physiology
MH  - Disease Progression
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - NF-kappa B/*metabolism
MH  - Osteopontin
MH  - Polymerase Chain Reaction
MH  - Squamous Cell Carcinoma of Head and Neck/genetics/*metabolism/pathology
MH  - Up-Regulation
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma
OT  - NF-kappaB signaling pathway
OT  - interferon-induced transmembrane protein 1 (IFITM1)
OT  - migration
OT  - osteopontin
OT  - proliferation
OT  - therapeutic target
EDAT- 2020/09/01 06:00
MHDA- 2021/08/06 06:00
CRDT- 2020/09/01 06:00
PHST- 2020/09/01 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
PHST- 2020/09/01 06:00 [entrez]
AID - CBM201435 [pii]
AID - 10.3233/CBM-201435 [doi]
PST - ppublish
SO  - Cancer Biomark. 2020;29(4):521-529. doi: 10.3233/CBM-201435.