PMID- 32866736 OWN - NLM STAT- MEDLINE DCOM- 20210111 LR - 20210111 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 144 DP - 2020 Nov TI - Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring. PG - 105811 LID - S0160-4120(20)31766-9 [pii] LID - 10.1016/j.envint.2020.105811 [doi] AB - Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as BPA replacements, are being increasingly detected in human biological matrices. BPA and some of its analogues are classified as endocrine disruptors suspected of contributing to adverse health outcomes such as altered reproduction and neurodevelopment, obesity, and metabolic disorders among other developmental and chronic impairments. One of the aims of the H2020 European Human Biomonitoring Initiative (HBM4EU) is the implementation of effect biomarkers at large scales in future HBM studies in a systematic and standardized way, in order to complement exposure data with mechanistically-based biomarkers of early adverse effects. This review aimed to identify and prioritize existing biomarkers of effect for BPA, as well as to provide relevant mechanistic and adverse outcome pathway (AOP) information in order to cover knowledge gaps and better interpret effect biomarker data. A comprehensive literature search was performed in PubMed to identify all the epidemiologic studies published in the last 10 years addressing the potential relationship between bisphenols exposure and alterations in biological parameters. A total of 5716 references were screened, out of which, 119 full-text articles were analyzed and tabulated in detail. This work provides first an overview of all epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid and thyroid hormones, metabolic and allergy/immune biomarkers previously studied. Then, promising effect biomarkers related to altered neurodevelopmental and reproductive outcomes including brain-derived neurotrophic factor (BDNF), kisspeptin (KiSS), and gene expression of nuclear receptors are prioritized, providing mechanistic insights based on in vitro, animal studies and AOP information. Finally, the potential of omics technologies for biomarker discovery and its implications for risk assessment are discussed. To the best of our knowledge, this is the first effort to comprehensively identify bisphenol-related biomarkers of effect for HBM purposes. CI - Copyright (c) 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Mustieles, Vicente AU - Mustieles V AD - University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigacion Biosanitaria (ibs. GRANADA), Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain. Electronic address: vmustieles@ugr.es. FAU - D'Cruz, Shereen Cynthia AU - D'Cruz SC AD - Univ Rennes, EHESP, Inserm, Irset (Institut de recherche en sante, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. FAU - Couderq, Stephan AU - Couderq S AD - Evolution des Regulations Endocriniennes, Departement "Adaptation du Vivant", UMR 7221 MNHN/CNRS, Sorbonne Universite, Paris 75006, France. FAU - Rodriguez-Carrillo, Andrea AU - Rodriguez-Carrillo A AD - University of Granada, Center for Biomedical Research (CIBM), Spain. FAU - Fini, Jean-Baptiste AU - Fini JB AD - Evolution des Regulations Endocriniennes, Departement "Adaptation du Vivant", UMR 7221 MNHN/CNRS, Sorbonne Universite, Paris 75006, France. FAU - Hofer, Tim AU - Hofer T AD - Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, P.O. Box 222 Skoyen, NO-0213 Oslo, Norway. FAU - Steffensen, Inger-Lise AU - Steffensen IL AD - Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, P.O. Box 222 Skoyen, NO-0213 Oslo, Norway. FAU - Dirven, Hubert AU - Dirven H AD - Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, P.O. Box 222 Skoyen, NO-0213 Oslo, Norway. FAU - Barouki, Robert AU - Barouki R AD - University Paris Descartes, ComUE Sorbonne Paris Cite, Paris, France. Institut national de la sante et de la recherche medicale (INSERM, National Institute of Health & Medical Research) UMR S-1124, Paris, France. FAU - Olea, Nicolas AU - Olea N AD - University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigacion Biosanitaria (ibs. GRANADA), Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain. FAU - Fernandez, Mariana F AU - Fernandez MF AD - University of Granada, Center for Biomedical Research (CIBM), Spain; Instituto de Investigacion Biosanitaria (ibs. GRANADA), Spain; Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain. Electronic address: marieta@ugr.es. FAU - David, Arthur AU - David A AD - Univ Rennes, EHESP, Inserm, Irset (Institut de recherche en sante, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address: arthur.david@ehesp.fr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20200828 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Benzhydryl Compounds) RN - 0 (Biomarkers) RN - 0 (Phenols) RN - MLT3645I99 (bisphenol A) SB - IM MH - Animals MH - *Benzhydryl Compounds/toxicity MH - *Biological Monitoring MH - Biomarkers MH - Humans MH - Phenols/toxicity OTO - NOTNLM OT - Adverse outcome pathway OT - Bisphenol A OT - Bisphenol analogues OT - Effect biomarker OT - Human biomonitoring EDAT- 2020/09/01 06:00 MHDA- 2021/01/12 06:00 CRDT- 2020/09/01 06:00 PHST- 2020/01/22 00:00 [received] PHST- 2020/04/24 00:00 [revised] PHST- 2020/05/07 00:00 [accepted] PHST- 2020/09/01 06:00 [pubmed] PHST- 2021/01/12 06:00 [medline] PHST- 2020/09/01 06:00 [entrez] AID - S0160-4120(20)31766-9 [pii] AID - 10.1016/j.envint.2020.105811 [doi] PST - ppublish SO - Environ Int. 2020 Nov;144:105811. doi: 10.1016/j.envint.2020.105811. Epub 2020 Aug 28.