PMID- 32867891
OWN - NLM
STAT- MEDLINE
DCOM- 20210825
LR  - 20210825
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 41
IP  - 5
DP  - 2020 Sep 1
TI  - Effect of perennial dust mites allergy on symptom severity of autumn allergic 
      rhinitis in adults.
PG  - 363-371
LID - 10.2500/aap.2020.41.200046 [doi]
AB  - Background: Multiple immunoglobulin E (IgE) mediated sensitizations and/or 
      allergies often coexist in patients with allergic rhinitis (AR). Several 
      simultaneous allergen exposures in multiple IgE-mediated sensitizations and/or 
      allergies may increase the allergen load and be related to disease severity. No 
      study has verified whether positive allergen serum IgE levels and allergen 
      categories together are associated with AR severity in adults. Objective: To 
      investigate the effects of perennial dust mites (DMs) allergy and multiple serum 
      sIgE-mediated autumn pollen allergy coexistence on symptom severity in adult 
      patients with AR in autumn. Methods: In total, 153 patients with AR and with 
      autumn pollen allergy (Artemisia argyi, ragweed, and hop) with or without DMs 
      allergy were recruited in the autumn pollen season. Symptom severity was assessed 
      by using the Chinese version of the visual analog scale (VAS): four rhinitis 
      symptoms (sneezing, rhinorrhea, nasal pruritus, and nasal congestion) and two 
      ocular symptoms (ocular itching and/or grittiness and/or redness, and ocular 
      tearing) were scored at approximately the same period. We measured allergen serum 
      sIgE levels for the inhaled allergens. The effects of DMs allergy and multiple 
      autumn pollen allergy coexistence on symptom severity were analyzed. Results: 
      Neither the sum of the autumn pollen allergens categories (total number of 
      positive autumn pollen allergens, i.e., Artemisia argyi or ragweed or hop 
      positive: 1; Artemisia argyi and ragweed positive: 2; Artemisia argyi, ragweed, 
      and hop positive: 3) nor serum sIgE levels( total sIgE levels of positive autumn 
      pollen allergens) exerted any influence on the severity of nasal and ocular 
      symptoms (p > 0.05). When the concomitant DMs allergy status was considered, the 
      sum of the positive autumn pollen allergen categories and accumulated positive 
      autumn pollen and DMs serum sIgE levels (total levels of serum sIgE of positive 
      autumn pollen allergens plus the levels of serum sIgE of DMs) had no influence on 
      patients' symptom severity (p > 0.05). Conclusion: The coexistence of perennial 
      DMs allergy and multiple autumn pollen allergy did not affect the severity of 
      symptoms among adult patients with AR and with autumn pollen allergy in autumn.
FAU - Xu, Qingqing
AU  - Xu Q
AD  - From the Department of Allergy, Beijing TongRen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - From the Department of Allergy, Beijing TongRen Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Luo
AU  - Zhang L
AD  - From the Department of Allergy, Beijing TongRen Hospital, Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Antigens, Plant)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Ambrosia/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/*immunology
MH  - Antigens, Plant/*immunology
MH  - Artemisia/immunology
MH  - Female
MH  - Humans
MH  - Humulus/immunology
MH  - Hypersensitivity/complications/*physiopathology
MH  - Immunization
MH  - Immunoglobulin E/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Pollen/*immunology
MH  - Pyroglyphidae/immunology
MH  - Rhinitis, Allergic, Seasonal/complications/*physiopathology
MH  - Seasons
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2020/09/02 06:00
MHDA- 2021/08/26 06:00
CRDT- 2020/09/02 06:00
PHST- 2020/09/02 06:00 [entrez]
PHST- 2020/09/02 06:00 [pubmed]
PHST- 2021/08/26 06:00 [medline]
AID - 10.2500/aap.2020.41.200046 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2020 Sep 1;41(5):363-371. doi: 10.2500/aap.2020.41.200046.