PMID- 32869893
OWN - NLM
STAT- MEDLINE
DCOM- 20210407
LR  - 20210407
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 131
IP  - 4
DP  - 2021 Apr
TI  - Disparities in Mortality from Larynx Cancer: Implications for Reducing Racial 
      Differences.
PG  - E1147-E1155
LID - 10.1002/lary.29046 [doi]
AB  - OBJECTIVE: Race predicts overall mortality (OM) of laryngeal squamous cell 
      carcinoma (LSCC) in the United States (US). We assessed whether racial 
      disparities affect cancer-specific mortality (CSM) using the Surveillance, 
      Epidemiology, and End Results (SEER) database. METHODS: Adults with LSCC from 
      2004 to 2015 were selected. Univariable and multivariable Cox proportional 
      hazards and Fine-Gray competing-risks regression analysis adjusted for 
      clinicodemographic factors defined hazard ratios (aHR). RESULTS: We identified 
      14,506 patients. The median age was 63 years. Most were male (11,725, 80.8%) and 
      white (11,653, 80.3%), followed by Black (2294, 15.8%). Most had early-stage 
      disease (7544, 52.0%) and received radiotherapy only (4107, 28.3%), followed by 
      chemoradiation (3748, 25.8%). With median follow-up of 60 months, overall 3- and 
      5-year OM were 34.0% and 43.2%; CSM were 16.0% and 18.9%, respectively. Black 
      patients had higher OM than white patients on univariable (HR 1.35, 95% CI, 
      1.26-1.44, P < .001) and multivariable (aHR 1.10, 95% CI, 1.02-1.18, P = .011) 
      analyses. Black patients had higher CSM on univariable analysis (HR 1.22, 95% CI, 
      1.09-1.35, P < .001) but not on multivariable CSM analysis (aHR 1.01, 95% CI, 
      0.90-1.13, P = .864). On multivariable analysis, year of diagnosis, age, disease 
      site, stage, treatment, nodal metastasis, marital status, education, and 
      geography significantly predicted CSM. CONCLUSION: On multivariable analyses 
      controlling for sociodemographic, clinical, and treatment characteristics, Black 
      and white patients differed in OM but not in CSM. However, Black patients 
      presented with greater proportions of higher stage cancers and sociodemographic 
      factors such as income and marital status that were associated with worse 
      outcomes. Efforts to target sociodemographic disparities may contribute to the 
      mitigation of racial disparities in LSCC. LEVEL OF EVIDENCE: 4 Laryngoscope, 
      131:E1147-E1155, 2021.
CI  - (c) 2020 American Laryngological, Rhinological and Otological Society Inc, "The 
      Triological Society" and American Laryngological Association (ALA).
FAU - Chen, Sophia
AU  - Chen S
AUID- ORCID: 0000-0002-9364-3042
AD  - Department of Otolaryngology-Head & Neck Surgery, New York University School of 
      Medicine, New York, New York, U.S.A.
FAU - Dee, Edward Christopher
AU  - Dee EC
AUID- ORCID: 0000-0001-6119-0889
AD  - Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
AD  - Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts, 
      U.S.A.
FAU - Muralidhar, Vinayak
AU  - Muralidhar V
AD  - Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
FAU - Nguyen, Paul L
AU  - Nguyen PL
AD  - Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and 
      Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
FAU - Amin, Milan R
AU  - Amin MR
AD  - Department of Otolaryngology-Head & Neck Surgery, New York University Langone 
      Health, New York, New York, U.S.A.
FAU - Givi, Babak
AU  - Givi B
AD  - Department of Otolaryngology-Head & Neck Surgery, New York University Langone 
      Health, New York, New York, U.S.A.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200901
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*ethnology/*mortality/therapy
MH  - Female
MH  - *Health Status Disparities
MH  - Humans
MH  - Laryngeal Neoplasms/*ethnology/*mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - SEER Program
MH  - United States
OTO - NOTNLM
OT  - Laryngeal cancer, head and neck cancer, racial disparities, overall mortality, 
      cancer-specific mortality
EDAT- 2020/09/02 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/09/02 06:00
PHST- 2020/06/12 00:00 [received]
PHST- 2020/07/14 00:00 [revised]
PHST- 2020/07/27 00:00 [accepted]
PHST- 2020/09/02 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/09/02 06:00 [entrez]
AID - 10.1002/lary.29046 [doi]
PST - ppublish
SO  - Laryngoscope. 2021 Apr;131(4):E1147-E1155. doi: 10.1002/lary.29046. Epub 2020 Sep 
      1.