PMID- 3287004
OWN - NLM
STAT- MEDLINE
DCOM- 19880707
LR  - 20190817
IS  - 0022-4804 (Print)
IS  - 0022-4804 (Linking)
VI  - 44
IP  - 5
DP  - 1988 May
TI  - A comparison between intrarectal ultrasound and CT scanning in staging of 
      experimental rectal tumors.
PG  - 522-6
AB  - The purpose of this study was to compare the accuracy of preoperative staging of 
      experimental rectal tumors by digital rectal exam, intrarectal ultrasound (IRUS), 
      and CT scanning with pathologic exam. Rectal tumor masses were induced in 10 
      mongrel dogs by submucosal injection of 2-3 cc of Freund's complete adjuvant. One 
      week later, the animals underwent digital rectal exam, IRUS, and pelvic CT scans. 
      Pelvic exenteration specimens were submitted for pathologic evaluation. 
      Evaluations and interpretations were done in blinded fashion by independent 
      examiners. The rectal "tumor" was detected in 9 of 10 digital exams, 10 of 10 
      IRUS exams, and 1 of 10 CT scans. Correct Duke's staging occurred in 70% of 
      digital exams, 90% of IRUS exams, and 10% of CT exams compared to pathological 
      staging. Lymph nodes were detected on pathologic exam in all animals (8.7/animal, 
      range 3-16), on IRUS in all animals (6.4/animal, range 5-13), and in none of the 
      digital or CT examinations. IRUS was significantly more accurate in detecting (P 
      less than 0.0001) and locally staging tumors (P less than 0.0001), and in 
      detecting and localizing lymphadenopathy compared to CT scan. Intrarectal 
      ultrasound is a simple, highly accurate device for assessing depth of wall 
      penetration of rectal tumors and in detecting pararectal lymph nodes and should 
      be considered the preoperative staging procedure of choice for rectal cancer.
FAU - Senagore, A
AU  - Senagore A
AD  - Department of Surgical Research, Ferguson Clinic, Grand Rapids, Michigan 49503.
FAU - Milsom, J W
AU  - Milsom JW
FAU - Senagore, P
AU  - Senagore P
FAU - Mazier, W P
AU  - Mazier WP
FAU - Scholten, D J
AU  - Scholten DJ
FAU - Zydbel, P
AU  - Zydbel P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
SB  - IM
MH  - Animals
MH  - Lymph Nodes/pathology
MH  - Neoplasm Staging/*methods
MH  - Rectal Neoplasms/*pathology
MH  - Rectum/diagnostic imaging/*pathology
MH  - *Tomography, X-Ray Computed
MH  - *Ultrasonography
EDAT- 1988/05/01 00:00
MHDA- 1988/05/01 00:01
CRDT- 1988/05/01 00:00
PHST- 1988/05/01 00:00 [pubmed]
PHST- 1988/05/01 00:01 [medline]
PHST- 1988/05/01 00:00 [entrez]
AID - 0022-4804(88)90157-6 [pii]
AID - 10.1016/0022-4804(88)90157-6 [doi]
PST - ppublish
SO  - J Surg Res. 1988 May;44(5):522-6. doi: 10.1016/0022-4804(88)90157-6.