PMID- 32871147
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 191
DP  - 2020 Dec
TI  - Association between prenatal exposure to perfluoroalkyl substances and 
      respiratory tract infections in preschool children.
PG  - 110156
LID - S0013-9351(20)31053-7 [pii]
LID - 10.1016/j.envres.2020.110156 [doi]
AB  - BACKGROUND: Prenatal exposure to perfluoroalkyl substances (PFAS) is considered 
      to affect adversely the immune function. However, the effect of prenatal PFAS 
      exposure on respiratory tract infections (RTIs) in children is unclear. Thus, we 
      evaluated whether cord blood PFAS levels were associated with RTI in the first 5 
      years of life. METHODS: The Shanghai Prenatal Cohort is an on-going birth cohort, 
      which included all the mothers during pregnancy. Children were followed by 
      paediatricians once a year after birth. The levels of 10 PFAS in cord blood were 
      tested using liquid chromatography-mass spectrometry. RTIs were diagnosed based 
      on face-to-face interviews with the parents and review of medical records. 
      Immunoglobulin G (IgG) and immunoglobulin E (IgE) levels, as biomarkers of 
      humoral immunity, were assessed using enzyme-linked immunosorbent assay at age 5 
      years. Multivariable logistic and linear regression models were applied to study 
      the association between prenatal PFAS exposure and RTIs. RESULTS: A total of 743 
      children completed the follow-up, 344 of them had detail information of cord 
      blood PFAS, IgG, and IgE concentrations. Eight PFAS were detected in more than 
      90% of the cord blood samples, except for perfluoroheptanoic acid (PFHpA) and 
      perfluorooctane sulfonamide (FOSA). During the 5-year follow-up period, the 
      frequency of RTIs increased with age, reaching a peak at age 4. Moreover, 20.6% 
      of the children were diagnosed with recurrent RTIs. Children with recurrent RTIs 
      had higher prenatal perfluorobutane sulfonic acid (PFBS) concentration. Higher 
      prenatal PFBS concentration was positively associated with total RTI frequency 
      (beta = 6.05, 95% CI [0.84, 11.26]) in first 5 years of life and negatively 
      associated with IgG level (beta = -0.82, 95% CI [-1.67, -0.01]) at age 5. 
      CONCLUSIONS: Children with higher prenatal PFBS were more vulnerable to RTIs in 
      early life, which may be attributed to immunosuppression of IgG production. These 
      findings need to be further verified in larger prospective studies.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Huang, Heyu
AU  - Huang H
AD  - Department of Pediatric Infectious Disease, Xinhua Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Yu, Kan
AU  - Yu K
AD  - Department of Pediatric Infectious Disease, Xinhua Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zeng, Xinxin
AU  - Zeng X
AD  - Department of Pediatric Infectious Disease, Xinhua Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Liu, Quanhua
AU  - Liu Q
AD  - Department of Pediatric Respiratory Disease, Xinhua Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhao, Yanjun
AU  - Zhao Y
AD  - Department of Developmental Behavior Pediatrics & Child Primary Care, Children's 
      Hospital of Shanghai Jiao Tong University, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
FAU - Zhang, Xi
AU  - Zhang X
AD  - Clinical Research Unit, Xinhua Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China. Electronic address: 
      zhangxi@xinhuamed.com.cn.
FAU - Huang, Lisu
AU  - Huang L
AD  - Department of Pediatric Infectious Disease, Xinhua Hospital Affiliated to 
      Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic 
      address: huanglisu@xinhuamed.com.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200830
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - *Alkanesulfonic Acids/toxicity
MH  - Child, Preschool
MH  - China/epidemiology
MH  - *Environmental Pollutants
MH  - Female
MH  - *Fluorocarbons/toxicity
MH  - Humans
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology
MH  - Prospective Studies
MH  - *Respiratory Tract Infections
OTO - NOTNLM
OT  - Immunoglobulin G
OT  - Perfluoroalkyl substances
OT  - Prenatal exposure
OT  - Prospective birth cohort study
OT  - Respiratory tract infections
EDAT- 2020/09/02 06:00
MHDA- 2021/01/12 06:00
CRDT- 2020/09/02 06:00
PHST- 2020/04/08 00:00 [received]
PHST- 2020/08/18 00:00 [revised]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/09/02 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/09/02 06:00 [entrez]
AID - S0013-9351(20)31053-7 [pii]
AID - 10.1016/j.envres.2020.110156 [doi]
PST - ppublish
SO  - Environ Res. 2020 Dec;191:110156. doi: 10.1016/j.envres.2020.110156. Epub 2020 
      Aug 30.