PMID- 32871196
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210707
IS  - 1873-3441 (Electronic)
IS  - 0939-6411 (Linking)
VI  - 156
DP  - 2020 Nov
TI  - Electrospinning/electrospraying coatings for metal microneedles: A design of 
      experiments (DOE) and quality by design (QbD) approach.
PG  - 20-39
LID - S0939-6411(20)30267-8 [pii]
LID - 10.1016/j.ejpb.2020.08.023 [doi]
AB  - The research presented here shows QbD implementation for the optimisation of the 
      key process parameters in electrohydrodynamic atomisation (EHDA). Here, the 
      electrosprayed nanoparticles and electrospun fibers consisting of a polymeric 
      matrix and dye. Eight formulations were assessed consisting of 5% w/v of 
      polycaprolactone (PCL) in dichloromethane (DCM) and 5% w/v polyvinylpyrrolidone 
      (PVP) in ethanol. A full factorial DOE was used to assess the various parameters 
      (applied voltage, deposition distance, flow rate). Further particle and fiber 
      analysis using Scanning Electron Microscopy (SEM), Differential Scanning 
      Calorimetry (DSC), Thermogravimetric Analysis (TGA), Fourier Transform Infrared 
      Spectroscopy (FTIR), particle/fiber size distribution. In addition to this in 
      vitro release studied were carried out using fluorescein and Rhodamine B as model 
      dyes and in vitro permeation studies were applied. The results show a significant 
      difference in the morphology of resultant structures as well as a more rapid 
      release profile for the PVP particles and fibers in comparison to the sustained 
      release profiles found with PCL. In vitro drug release studies showed 100% drug 
      release after 7 days for PCL particles and showed 100% drug release within 
      120 min for PVP particles. The release kinetics and the permeation study showed 
      that the MN successfully pierced the membrane and the electrospun MN coating 
      released a large amount of the loaded drug within 6 h. This study has 
      demonstrated the capability of these robust MNs to encapsulate a diverse range 
      drugs within a polymeric matrix giving rise to the potential of developed 
      personalised medical devices.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Ali, Radeyah
AU  - Ali R
AD  - Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
FAU - Mehta, Prina
AU  - Mehta P
AD  - Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
FAU - Kyriaki Monou, Paraskevi
AU  - Kyriaki Monou P
AD  - Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University 
      of Thessaloniki, Greece.
FAU - Arshad, Muhammad S
AU  - Arshad MS
AD  - Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
FAU - Panteris, Emmanuel
AU  - Panteris E
AD  - Department of Botany, School of Biology, Aristotle University of Thessaloniki, 
      GR-54124 Thessaloniki, Greece.
FAU - Rasekh, Manoochehr
AU  - Rasekh M
AD  - Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK; 
      College of Engineering, Design and Physical Sciences, Brunel University London, 
      Middlesex UB8 3PH, UK.
FAU - Singh, Neenu
AU  - Singh N
AD  - Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
FAU - Qutachi, Omar
AU  - Qutachi O
AD  - Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
FAU - Wilson, Philippe
AU  - Wilson P
AD  - School of Animal, Rural and Environmental Sciences, Nottingham Trent University, 
      Brackenhurst Campus, Southwell NG25 0QF, UK.
FAU - Tzetzis, Dimitrios
AU  - Tzetzis D
AD  - School of Science and Technology, International Hellenic University, Thermi, 
      Greece.
FAU - Chang, Ming-Wei
AU  - Chang MW
AD  - Nanotechnology and Integrated Bioengineering Centre, University of Ulster, 
      Jordanstown Campus, Newtownabbey, Northern Ireland BT37 0QB, UK.
FAU - Fatouros, Dimitrios G
AU  - Fatouros DG
AD  - Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University 
      of Thessaloniki, Greece. Electronic address: dfatouro@pharm.auth.gr.
FAU - Ahmad, Zeeshan
AU  - Ahmad Z
AD  - Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK. 
      Electronic address: zahmad@dmu.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20200829
PL  - Netherlands
TA  - Eur J Pharm Biopharm
JT  - European journal of pharmaceutics and biopharmaceutics : official journal of 
      Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JID - 9109778
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 24980-41-4 (polycaprolactone)
RN  - FZ989GH94E (Povidone)
SB  - IM
MH  - Drug Liberation
MH  - Microinjections/*instrumentation/standards
MH  - *Needles/standards
MH  - Polyesters/chemistry/standards
MH  - Polymers/*chemistry/standards
MH  - Povidone/chemistry/standards
MH  - *Qualitative Research
MH  - Spectroscopy, Fourier Transform Infrared/methods
MH  - Technology, Pharmaceutical/*instrumentation/standards
OTO - NOTNLM
OT  - Electrohydrodynamic atomisation
OT  - Microneedles
OT  - Quality by design
OT  - Transdermal delivery
EDAT- 2020/09/02 06:00
MHDA- 2021/07/08 06:00
CRDT- 2020/09/02 06:00
PHST- 2020/03/19 00:00 [received]
PHST- 2020/08/11 00:00 [revised]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/09/02 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2020/09/02 06:00 [entrez]
AID - S0939-6411(20)30267-8 [pii]
AID - 10.1016/j.ejpb.2020.08.023 [doi]
PST - ppublish
SO  - Eur J Pharm Biopharm. 2020 Nov;156:20-39. doi: 10.1016/j.ejpb.2020.08.023. Epub 
      2020 Aug 29.