PMID- 32871531
OWN - NLM
STAT- MEDLINE
DCOM- 20210305
LR  - 20220323
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 277
DP  - 2020 Dec 1
TI  - Association of pro-inflammatory cytokines with clinical features in euthymic 
      patients with Bipolar-I-Disorder.
PG  - 450-455
LID - S0165-0327(20)32578-7 [pii]
LID - 10.1016/j.jad.2020.07.125 [doi]
AB  - BACKGROUND: A chronic low-grade inflammatory state appears to be a relevant 
      mechanism in the pathophysiology of bipolar disorder. Pro-inflammatory cytokines 
      may influence disease course and individual symptomatology; and biological 
      markers correlating with illness features may be of utility in clinical decision 
      making during euthymia. METHODS: 51 euthymic outpatients with Bipolar-I-Disorder 
      (BD-I) and 93 healthy controls (HC) were investigated. Comparisons between 
      groups, and correlations with clinical features were performed. Serum 
      concentrations of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and 
      soluble interleukin-6 receptor (sIL-6R) were evaluated by ELISA under highly 
      standardized conditions. Clinical features included duration of illness, number 
      of previous suicide attempts and mood episodes (manic, hypomanic, depressive), 
      scores of the Young Mania Rating Scale (YMRS), the Inventory of Depressive 
      Symptoms (IDS-30), the Pittsburg Sleep Quality Index (PSQI), and the Global 
      Assessment of Functioning (GAF). RESULTS: No significant difference in serum 
      concentrations of IL-1beta, TNF-alpha, and sIL-6R between BD-I euthymic patients and HC 
      could be identified. Among euthymic BD-I patients, a positive correlation of 
      r(s) = 0.47 (p = 0.004) between levels of IL-1beta and IDS-30 score was identified. 
      LIMITATIONS: The design was cross-sectional, most patients were receiving 
      medication, only 3 cytokines were assessed, only euthymic BD-I patients were 
      evaluated. CONCLUSIONS: The findings suggest that elevated pro-inflammatory 
      cytokine concentrations are likely state rather than trait markers of BD-I. It 
      also seems unlikely that cytokine concentrations are clinically informative 
      interepisode. An inflammatory component might possibly be involved in the 
      pathophysiology of subsyndromic depression in BD-I, and conceivably of bipolar 
      depression per se.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Vares, Edgar Arrua
AU  - Vares EA
AD  - Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav 
      Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Lehmann, Sarah
AU  - Lehmann S
AD  - Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav 
      Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Sauer, Cathrin
AU  - Sauer C
AD  - Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav 
      Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Pariante, Carmine
AU  - Pariante C
AD  - Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College 
      London.
FAU - Wieland, Falk
AU  - Wieland F
AD  - Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav 
      Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Soltmann, Bettina
AU  - Soltmann B
AD  - Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav 
      Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Bauer, Michael
AU  - Bauer M
AD  - Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav 
      Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
FAU - Ritter, Philipp
AU  - Ritter P
AD  - Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav 
      Carus, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. 
      Electronic address: Philipp.Ritter@uniklinikum-dresden.de.
LA  - eng
GR  - G108/603/MRC_/Medical Research Council/United Kingdom
GR  - MR/J002739/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/N029488/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200801
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Biomarkers
MH  - *Bipolar Disorder
MH  - Cross-Sectional Studies
MH  - Cyclothymic Disorder
MH  - Cytokines
MH  - Humans
OTO - NOTNLM
OT  - Bipolar depression
OT  - Bipolar disorder
OT  - Clinical features
OT  - Inflammation
OT  - Pro-inflammatory cytokines
OT  - State or trait
EDAT- 2020/09/02 06:00
MHDA- 2021/03/06 06:00
CRDT- 2020/09/02 06:00
PHST- 2020/04/12 00:00 [received]
PHST- 2020/06/25 00:00 [revised]
PHST- 2020/07/28 00:00 [accepted]
PHST- 2020/09/02 06:00 [pubmed]
PHST- 2021/03/06 06:00 [medline]
PHST- 2020/09/02 06:00 [entrez]
AID - S0165-0327(20)32578-7 [pii]
AID - 10.1016/j.jad.2020.07.125 [doi]
PST - ppublish
SO  - J Affect Disord. 2020 Dec 1;277:450-455. doi: 10.1016/j.jad.2020.07.125. Epub 
      2020 Aug 1.