PMID- 32871903
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20240329
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 35
DP  - 2020 Aug 28
TI  - Pregnancy outcomes and the dose-related effects of acupuncture therapies in women 
      undergoing in vitro fertilization: A protocol for systematic review and 
      meta-analysis.
PG  - e21815
LID - 10.1097/MD.0000000000021815 [doi]
LID - e21815
AB  - BACKGROUND: Previous studies have given an inaccurate assessment of the role of 
      acupuncture in in vitro fertilization (IVF). We will use acupuncture doses as an 
      entry point, discussing the dose-related effects of acupuncture therapy in women 
      undergoing IVF. METHODS: This study will search the following database: EMBASE, 
      PubMed, Web of Science, the Cochrane Central Register of Controlled Trials 
      (CENTRAL), and 4 Chinese databases. All databases will be searched from the date 
      of database establishment to January 31, 2019. In addition, we will search 
      possible studies which were included in previous meta-analyses. The primary 
      outcomes are the clinical pregnancy rate (CPR) and the live birth rate (LBR). The 
      secondary outcomes involved the biochemical pregnancy rate (BPR), the ongoing 
      pregnancy rate (OPR), serum hormone level, the incidence of ovarian 
      hyper-stimulation syndrome (OHSS), the cycle cancellation rates, and adverse 
      events (AEs). After checking and integrating the raw data, we will use a 2-step 
      to conduct the meta-analysis. Firstly, we will assess the effect of acupuncture 
      on in vitro fertilization and embryo transfer (IVF-ET). Secondly, the 
      meta-analysis will be performed for studies with similar total number of 
      treatment sessions to investigate the dose-related effects of acupuncture. RevMan 
      V.5.3 statistical software will be used for meta-analysis. If it is not 
      appropriate for a meta-analysis, then a descriptive analysis will be conducted. 
      RESULTS: This study will investigate the relationship between pregnancy outcomes 
      and the doses of acupuncture therapy in women undergoing IVF, and answer whether 
      a higher-doses of acupuncture treatment will contribute to a better outcome of 
      IVF-ET. CONCLUSION: The funding of this meta-analysis may provide convincing 
      evidence for clinicians, benefitting more patients who crave children. INPLASY 
      REGISTRATION NUMBER: INPLASY202070072.
FAU - Zou, Zihao
AU  - Zou Z
AD  - Acupuncture-Moxibustion and Tuina School, Chengdu University of Traditional 
      Chinese Medicine.
FAU - Zheng, Qianhua
AU  - Zheng Q
AD  - Acupuncture-Moxibustion and Tuina School, Chengdu University of Traditional 
      Chinese Medicine.
FAU - Wen, Xin
AU  - Wen X
AD  - Acupuncture-Moxibustion and Tuina School, Chengdu University of Traditional 
      Chinese Medicine.
FAU - Yang, Zuoqin
AU  - Yang Z
AD  - Chengdu Pidu District Hospital of TCM/The 3rd Clinical Medical Hospital of 
      Chengdu University of TCM.
FAU - Hou, Tinghui
AU  - Hou T
AD  - Acupuncture-Moxibustion and Tuina School, Chengdu University of Traditional 
      Chinese Medicine.
FAU - Hao, Xinyu
AU  - Hao X
AD  - Acupuncture-Moxibustion and Tuina School, Chengdu University of Traditional 
      Chinese Medicine.
FAU - Zhou, Siyuan
AU  - Zhou S
AD  - Acupuncture-Moxibustion and Tuina School, Chengdu University of Traditional 
      Chinese Medicine.
FAU - Li, Ying
AU  - Li Y
AD  - Graduate School, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - *Acupuncture Therapy
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Live Birth
MH  - *Meta-Analysis as Topic
MH  - Ovarian Hyperstimulation Syndrome
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Research Design
MH  - *Systematic Reviews as Topic
PMC - PMC7458246
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/09/03 06:00
MHDA- 2020/09/15 06:00
PMCR- 2020/08/28
CRDT- 2020/09/03 06:00
PHST- 2020/09/03 06:00 [entrez]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2020/08/28 00:00 [pmc-release]
AID - 00005792-202008280-00046 [pii]
AID - MD-D-20-05927 [pii]
AID - 10.1097/MD.0000000000021815 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Aug 28;99(35):e21815. doi: 
      10.1097/MD.0000000000021815.