PMID- 32871909 OWN - NLM STAT- MEDLINE DCOM- 20200914 LR - 20221005 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 99 IP - 35 DP - 2020 Aug 28 TI - Effects of high-quality nursing care on psychological outcomes and quality of life in patients with hepatocellular carcinoma: A protocol of systematic review and meta-analysis. PG - e21855 LID - 10.1097/MD.0000000000021855 [doi] LID - e21855 AB - BACKGROUND: High quality nursing care (HQNC) has been reported to effectively prevent psychological disorders and improve the quality of life (QoL) in patients with hepatocellular carcinoma (HCC) during the treatment. However, the exact effect of HQNC remains controversial. This systematic review will be aimed to assess the effectiveness of HQNC on psychological disorders and QoL in patients with HCC. METHODS: Eligible prospective controlled clinical trials were searched from Google Scholar, Medline, Excerpt Medica Database (Embase), PubMed, Web of Science (WOS), Cochrane Library, China Scientific Journal Database (CSJD), China National Knowledge Infrastructure (CNKI), Chinese BioMedical Database (CBM) and Wanfang Database. Papers in English or Chinese published from January 2000 to July 2020 will be included without any restrictions. The clinical outcomes including psychological outcomes, QoL, and adverse events of HQNC in patients with HCC were systematically evaluated.Study selection and data extraction will be performed independently by two reviewers. Stata 14.0 and Review Manager 5.3 were used for data analysis. Methodological quality for each eligible study will be assessed by using Cochrane risk of bias tool. Subgroup and meta-regression analysis will be carried out depending on the availability of sufficient data. RESULTS: The results of this systematic review will be published in a peer-reviewed journal. CONCLUSION: The results of this study may provide helpful evidence of HQNC on psychological effects and QoL in patients with HCC. INPLASY REGISTRATION NUMBER: INPLASY202070096. FAU - Zhang, Lei AU - Zhang L AD - Department of Oncology, The People's Hospital of Taizhou, Taizhou, Jiangsu Province. FAU - Zhang, Xuan AU - Zhang X AD - Digestive Endoscopy Center, Liaocheng People's Hospital. FAU - Cui, Zhaokun AU - Cui Z AD - Department of Anesthesiology, Liaocheng Infectious Diseases Hospital, Liaocheng, Shandong Province. FAU - Zhou, Lijuan AU - Zhou L AD - Department of Nursing, The People's Hospital of Taizhou, Taizhou, Jiangsu Province. FAU - Qu, Kai AU - Qu K AD - Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province. FAU - Wang, Nannan AU - Wang N AUID- ORCID: 0000-0002-8165-3729 AD - The Sixth Ward of Hepatology Department, Qingdao Sixth People's Hospital, Qingdao, Shandong Province, PR China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Anxiety/etiology MH - Carcinoma, Hepatocellular/*nursing/*psychology MH - Depression/etiology MH - Humans MH - Liver Neoplasms/*nursing/*psychology MH - *Meta-Analysis as Topic MH - Pain Measurement MH - Quality of Health Care MH - Quality of Life MH - Research Design MH - *Systematic Reviews as Topic PMC - PMC7458187 COIS- The authors have no conflicts of interests to disclose. EDAT- 2020/09/03 06:00 MHDA- 2020/09/15 06:00 PMCR- 2020/08/28 CRDT- 2020/09/03 06:00 PHST- 2020/09/03 06:00 [entrez] PHST- 2020/09/03 06:00 [pubmed] PHST- 2020/09/15 06:00 [medline] PHST- 2020/08/28 00:00 [pmc-release] AID - 00005792-202008280-00052 [pii] AID - MD-D-20-07228 [pii] AID - 10.1097/MD.0000000000021855 [doi] PST - ppublish SO - Medicine (Baltimore). 2020 Aug 28;99(35):e21855. doi: 10.1097/MD.0000000000021855.