PMID- 32871943
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 35
DP  - 2020 Aug 28
TI  - Evaluation of H-type hypertension prevalence and its influence on the risk of 
      increased carotid intima-media thickness among a high-risk stroke population in 
      Hainan Province, China.
PG  - e21953
LID - 10.1097/MD.0000000000021953 [doi]
LID - e21953
AB  - H-type hypertension, defined as a combination of hypertension and 
      hyperhomocysteinemia (Hhcy), is associated with atherosclerosis and, therefore, 
      increased stroke risk. However, the role of hypertension and Hhcy in high-risk 
      stroke populations has not been studied. The present study investigated the 
      prevalence of H-type hypertension in a high-risk stroke population of Hainan 
      Province, China and to assess possible joint effects between hypertension and 
      Hhcy for increased carotid intima-media thickness (CIMT). In this community-based 
      cross-sectional study, 959 high-risk stroke subjects (age, 65.8 +/- 10.8 years; 
      46.6% men) were recruited from Hainan Province, China. The demographic and 
      clinical characteristics were collected, and blood samples were obtained. 
      Analysis of variance or chi-square tests were performed to compare variates among 
      groups based on both homocysteine levels and blood pressure status. The 
      associations of hypertension and Hhcy with increased CIMT were evaluated through 
      logistic regression. The prevalence of H-type hypertension was 34.8% in this 
      population, with a higher ratio of H-type hypertension in men than in women. 
      Compared with the normotension and normal homocysteine subgroup, the risk of 
      increased CIMT was significantly higher in the subgroup with hypertension and 
      Hhcy (odds ratio [OR] = 2.639; 95% confidence interval [CI], 1.690-4.091) after 
      adjusting for age and sex. Increased CIMT was affected by an additive synergetic 
      interaction between Hhcy and hypertension (synergy index = 1.105). It emphasized 
      the clinical importance of anti-hypertension and lowering Hhcy in the high-risk 
      stroke population.
FAU - Zhou, Feng
AU  - Zhou F
AUID- ORCID: 0000-0002-2322-5793
AD  - Department of Neurology, First People's Hospital of Foshan, Foshan.
FAU - Hou, Dan
AU  - Hou D
AD  - Department of Neurology, Affiliated Haikou Hospital, Central South University 
      Xiangya School of Medicine, Haikou, China.
FAU - Wang, Yukai
AU  - Wang Y
AD  - Department of Neurology, First People's Hospital of Foshan, Foshan.
FAU - Yu, Dan
AU  - Yu D
AD  - Department of Neurology, Affiliated Haikou Hospital, Central South University 
      Xiangya School of Medicine, Haikou, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Carotid Intima-Media Thickness
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/physiopathology
MH  - Hypertension/*complications/epidemiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retrospective Studies
PMC - PMC7458159
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/09/03 06:00
MHDA- 2020/09/15 06:00
PMCR- 2020/08/28
CRDT- 2020/09/03 06:00
PHST- 2020/09/03 06:00 [entrez]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2020/08/28 00:00 [pmc-release]
AID - 00005792-202008280-00086 [pii]
AID - MD-D-19-01505 [pii]
AID - 10.1097/MD.0000000000021953 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Aug 28;99(35):e21953. doi: 
      10.1097/MD.0000000000021953.