PMID- 32871960
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 35
DP  - 2020 Aug 28
TI  - Fecal microbiota transplantation therapy for Parkinson's disease: A preliminary 
      study.
PG  - e22035
LID - 10.1097/MD.0000000000022035 [doi]
LID - e22035
AB  - Imbalances in the gut microbiota mediate the progression of neurodegenerative 
      diseases such as Parkinson's disease (PD). Fecal microbiota transplantation (FMT) 
      is currently being explored as a potential therapy for PD. The objective of this 
      study was to assess the efficacy and safety of FMT on PD. Fifteen PD patients 
      were included, 10 of them received FMT via colonoscopy (colonic FMT group) and 5 
      received FMT via nasal-jejunal tube (nasointestinal FMT group). The score of 
      PSQI, HAMD, HAMA, PDQ-39, NMSQ and UPDRS-III significantly decreased after FMT 
      treatment (all P < .05). Colonic FMT group showed significant improvement and 
      longer maintenance of efficacy compared with nasointestinal FMT (P = .002). Two 
      patients achieved self-satisfying outcomes that last for more than 24 months. 
      However, nasointestinal FMT group had no significant therapeutic effect, although 
      UPDRS-III score slightly reduced. There were no patients were satisfied with 
      nasointestinal FMT for more than 3 months. Among 15 PD patients, there were 5 
      cases had adverse events (AEs), including diarrhea (2 cases), abdominal pain (2 
      cases) and flatulence (1 case). These AEs were mild and self-limiting. We 
      conclude that FMT can relieve the motor and non-motor symptoms with acceptable 
      safety in PD. Compared with nasointestinal FMT, colonic FMT seems better and 
      preferable.
FAU - Xue, Liu-Jun
AU  - Xue LJ
AD  - Department of Neurology, The Affiliated Huaian No. 1 People's Hospital of Nanjing 
      Medical University.
FAU - Yang, Xiao-Zhong
AU  - Yang XZ
AD  - Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of 
      Nanjing Medical University, Huaian, Jiangsu Province, China.
FAU - Tong, Qiang
AU  - Tong Q
AD  - Department of Neurology, The Affiliated Huaian No. 1 People's Hospital of Nanjing 
      Medical University.
FAU - Shen, Peng
AU  - Shen P
AD  - Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of 
      Nanjing Medical University, Huaian, Jiangsu Province, China.
FAU - Ma, Shi-Jie
AU  - Ma SJ
AD  - Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of 
      Nanjing Medical University, Huaian, Jiangsu Province, China.
FAU - Wu, Shang-Nong
AU  - Wu SN
AD  - Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of 
      Nanjing Medical University, Huaian, Jiangsu Province, China.
FAU - Zheng, Jin-Long
AU  - Zheng JL
AD  - Department of Neurology, The Affiliated Huaian No. 1 People's Hospital of Nanjing 
      Medical University.
FAU - Wang, Hong-Gang
AU  - Wang HG
AUID- ORCID: 0000-0003-4761-0407
AD  - Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of 
      Nanjing Medical University, Huaian, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Colonoscopy
MH  - Fecal Microbiota Transplantation/adverse effects/methods/*statistics & numerical 
      data
MH  - Female
MH  - Humans
MH  - Intubation, Gastrointestinal
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*therapy
MH  - Patient Satisfaction
MH  - Pilot Projects
MH  - Young Adult
PMC - PMC7458210
COIS- The authors report no conflicts of interest.
EDAT- 2020/09/03 06:00
MHDA- 2020/09/15 06:00
PMCR- 2020/08/28
CRDT- 2020/09/03 06:00
PHST- 2020/09/03 06:00 [entrez]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2020/08/28 00:00 [pmc-release]
AID - 00005792-202008280-00103 [pii]
AID - MD-D-20-04459 [pii]
AID - 10.1097/MD.0000000000022035 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Aug 28;99(35):e22035. doi: 
      10.1097/MD.0000000000022035.