PMID- 32872002
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 33
DP  - 2020 Aug 14
TI  - The correlational study about neutrophil-to-lymphocyte ratio and exercise 
      tolerance of chronic obstructive pulmonary disease patients.
PG  - e21550
LID - 10.1097/MD.0000000000021550 [doi]
LID - e21550
AB  - To study the relationship between neutrophil to lymphocyte ratio (NLR) and 
      exercise tolerance of patients with chronic obstructive pulmonary disease 
      (COPD).235 patients with COPD were selected as the study subjects. Complete blood 
      count, C reactive protein (CRP), pulmonary function tests, the 6-minute walk 
      distance (6MWD), Modified Medical Respiratory Council, the COPD assessment test, 
      and clinical COPD questionnaire were tested. Heart rate, oxygen saturation, and 
      Borg scale were tested before or after 6MWD test.By the median of NLR, the 
      subjects were divided into 2 groups, NLR >/=4.5 group and NLR <4.5 group. The white 
      blood cell count (WBC), CRP and deoxygenation saturation in the NLR >/=4.5 group 
      were higher than those in the NLR <4.5 group, while the age, body mass index 
      (BMI), 6MWD, and heart rate variation were lower than those in the NLR <4.5 
      group. CRP, WBC, and deoxygenation saturation had positive effects on NLR, BMI, 
      6MWT, and heart rate variation had negative effects on NLR. The Pearson 
      correlation analysis showed NLR was positively correlated with WBC, CRP, BMI 
      index, 6MWT, and deoxygenation saturation, while it was negatively correlated 
      with BMI and heart rate variation.NLR might associate with exercise tolerance and 
      cardiorespiratory reserve of COPD patients, and could be used as an indicator of 
      muscle function in COPD patients.
FAU - Yuan, Lindong
AU  - Yuan L
AD  - Department of Respiratory Medicine, Liaocheng People's Hospital, Liaocheng, 
      Shandong, China.
FAU - Li, Lili
AU  - Li L
FAU - Yu, Tong
AU  - Yu T
FAU - Yang, Ziyun
AU  - Yang Z
FAU - Jiang, Tingting
AU  - Jiang T
FAU - Ma, Qiuxia
AU  - Ma Q
FAU - Qi, Jun
AU  - Qi J
FAU - Shi, Yan
AU  - Shi Y
FAU - Zhao, Peige
AU  - Zhao P
AUID- ORCID: 0000-0002-7268-7302
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - *Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Lymphocyte Count
MH  - Lymphocytes/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/*metabolism
MH  - Pulmonary Disease, Chronic Obstructive/*blood/*physiopathology
MH  - Respiratory Function Tests
MH  - Surveys and Questionnaires
MH  - Walk Test
PMC - PMC7437780
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/09/03 06:00
MHDA- 2020/09/15 06:00
PMCR- 2020/08/14
CRDT- 2020/09/03 06:00
PHST- 2020/09/03 06:00 [entrez]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2020/08/14 00:00 [pmc-release]
AID - 00005792-202008140-00036 [pii]
AID - MD-D-20-03627 [pii]
AID - 10.1097/MD.0000000000021550 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Aug 14;99(33):e21550. doi: 
      10.1097/MD.0000000000021550.