PMID- 32872032
OWN - NLM
STAT- MEDLINE
DCOM- 20200910
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 33
DP  - 2020 Aug 14
TI  - Long-term neurodevelopment outcomes of regional vs general anesthesia for infants 
      undergoing inguinal herniorrhaphy: A protocol for systematic review and 
      meta-analysis.
PG  - e21669
LID - 10.1097/MD.0000000000021669 [doi]
LID - e21669
AB  - BACKGROUND: Whether regional anesthesia (RA) offers better long-term 
      neurodevelopment outcomes compared to general anesthesia (GA) to infants 
      undergoing inguinal herniorrhaphy is still under heated debate. The aim of this 
      meta-analysis is to compare the long-term neurodevelopment impact of RA with GA 
      on infants undergoing inguinal herniorrhaphy. METHODS: A systematic search of 
      MEDLINE, EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, 
      clinicaltrials.gov and controlledtrials.com will be performed. Published eligible 
      randomized controlled trials (RCTs) or quasi-RCTs (including abstracts) through 
      May 20, 2020 with language limit of English will be enrolled in the 
      meta-analysis. Two reviewers will independently conduct the procedures of study 
      selection, data extraction, methodological quality assessment, and risk of bias 
      assessment. The primary outcome is long-term neurodevelopmental state (at 2- and 
      5-year follow-up) as reflected in the Bayley and the Wechsler Preschool and 
      Primary Scale of Intelligence (WPPSI) scales of infants development following 
      surgeries. The secondary outcomes consist of satisfactory intraoperative infants 
      immobility, duration of surgery, any anesthetic failure, the supplement of 
      postoperative analgesia, postoperative apnea, and postoperative bradycardia. The 
      pooled weighted mean differences (WMDs) or odds ratios (ORs) of each outcome 
      measurement and relative 95% confident intervals (CIs) will be calculated. 
      EndNote X8 (Clarivate Analytics) software will be applied to manage all 
      citations. The Cochrane Review Manager version 5.3 software (RevMan 5.3) will be 
      employed for statistical analysis. DISCUSSION: This study will summarize 
      scientific and practical evidence and provide evidence-based individualized 
      decision-making guidance on anesthesia regimen for inguinal herniorrhaphy in 
      infants. REGISTRATION: This protocol was registered with the International 
      Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 
      17 June 2020 (registration number INPLASY202060064).
FAU - Yuan, Tao
AU  - Yuan T
AD  - Department of Anesthesiology.
AD  - Translational Neuroscience Center, Laboratory of Anesthesia and Critical Care 
      Medicine.
FAU - Yang, Wenming
AU  - Yang W
AD  - Department of Gastrointestinal Surgery.
FAU - Yang, Lei
AU  - Yang L
AD  - Department of Anesthesiology.
AD  - Translational Neuroscience Center, Laboratory of Anesthesia and Critical Care 
      Medicine.
FAU - Liu, Xueting
AU  - Liu X
AD  - Department of Evidence-Based Medicine and Clinical Epidemiology, West China 
      Hospital of Sichuan University, Chengdu, China.
FAU - Yang, Lie
AU  - Yang L
AD  - Department of Gastrointestinal Surgery.
FAU - Li, Yu
AU  - Li Y
AUID- ORCID: 0000-0002-9277-1827
AD  - Department of Anesthesiology.
AD  - Translational Neuroscience Center, Laboratory of Anesthesia and Critical Care 
      Medicine.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Anesthesia, Conduction/*adverse effects
MH  - Anesthesia, General/*adverse effects
MH  - Child Development
MH  - Child, Preschool
MH  - Cognition/*drug effects
MH  - Hernia, Inguinal/surgery
MH  - Herniorrhaphy/*methods
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Meta-Analysis as Topic
MH  - Systematic Reviews as Topic
PMC - PMC7437770
COIS- The authors report no conflicts of interest.
EDAT- 2020/09/03 06:00
MHDA- 2020/09/12 06:00
PMCR- 2020/08/14
CRDT- 2020/09/03 06:00
PHST- 2020/09/03 06:00 [entrez]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2020/08/14 00:00 [pmc-release]
AID - 00005792-202008140-00066 [pii]
AID - MD-D-20-06343 [pii]
AID - 10.1097/MD.0000000000021669 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Aug 14;99(33):e21669. doi: 
      10.1097/MD.0000000000021669.