PMID- 32872402
OWN - NLM
STAT- MEDLINE
DCOM- 20210223
LR  - 20210223
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 17
DP  - 2020 Aug 29
TI  - Endocannabinoid-Epigenetic Cross-Talk: A Bridge toward Stress Coping.
LID - 10.3390/ijms21176252 [doi]
LID - 6252
AB  - There is no argument with regard to the physical and psychological stress-related 
      nature of neuropsychiatric disorders. Yet, the mechanisms that facilitate disease 
      onset starting from molecular stress responses are elusive. Environmental stress 
      challenges individuals' equilibrium, enhancing homeostatic request in the attempt 
      to steer down arousal-instrumental molecular pathways that underlie 
      hypervigilance and anxiety. A relevant homeostatic pathway is the endocannabinoid 
      system (ECS). In this review, we summarize recent discoveries unambiguously 
      listing ECS as a stress coping mechanism. As stress evokes huge excitatory 
      responses in emotional-relevant limbic areas, the ECS limits glutamate release 
      via 2-arachydonilglycerol (2-AG) stress-induced synthesis and retrograde 
      cannabinoid 1 (CB1)-receptor activation at the synapse. However, ECS shows 
      intrinsic vulnerability as 2-AG overstimulation by chronic stress rapidly leads 
      to CB1-receptor desensitization. In this review, we emphasize the protective role 
      of 2-AG in stress-response termination and stress resiliency. Interestingly, we 
      discuss ECS regulation with a further nuclear homeostatic system whose nature is 
      exquisitely epigenetic, orchestrated by Lysine Specific Demethylase 1. We here 
      emphasize a remarkable example of stress-coping network where transcriptional 
      homeostasis subserves synaptic and behavioral adaptation, aiming at reducing 
      psychiatric effects of traumatic experiences.
FAU - Rusconi, Francesco
AU  - Rusconi F
AD  - Department of Medical Biotechnology and Translational Medicine, Universita degli 
      Studi di Milano-Via Fratelli Cervi 93, 20090 Segrate (MI), Italy.
FAU - Rubino, Tiziana
AU  - Rubino T
AD  - Department of Biotechnology and Life Sciences, Universita degli Studi 
      dell'Insubria-Busto Arsizio (VA), 21052 Busto Arsizio, Italy.
FAU - Battaglioli, Elena
AU  - Battaglioli E
AD  - Department of Medical Biotechnology and Translational Medicine, Universita degli 
      Studi di Milano-Via Fratelli Cervi 93, 20090 Segrate (MI), Italy.
LA  - eng
GR  - 2016-0908/Fondazione Cariplo/
PT  - Journal Article
PT  - Review
DEP - 20200829
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Arachidonic Acids)
RN  - 0 (Endocannabinoids)
RN  - 0 (Glycerides)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 8D239QDW64 (glyceryl 2-arachidonate)
RN  - EC 1.14.11.- (Histone Demethylases)
SB  - IM
MH  - *Adaptation, Psychological
MH  - Animals
MH  - Arachidonic Acids/metabolism
MH  - Endocannabinoids/*metabolism
MH  - Epigenesis, Genetic
MH  - Glutamic Acid/metabolism
MH  - Glycerides/metabolism
MH  - Histone Demethylases/*metabolism
MH  - Homeostasis
MH  - Humans
MH  - Receptor, Cannabinoid, CB1/metabolism
PMC - PMC7504015
OTO - NOTNLM
OT  - 2-arachidonoylglycerol (2-AG)
OT  - Hypothalamus-Pituitary-Adrenocortical (HPA)
OT  - Lysine Specific Demethylase 1
OT  - endocannabinoid system
OT  - epigenetics
OT  - homeostasis
OT  - psychiatric disorders
COIS- The authors declare no conflict of interest.
EDAT- 2020/09/03 06:00
MHDA- 2021/02/24 06:00
PMCR- 2020/09/01
CRDT- 2020/09/03 06:00
PHST- 2020/07/20 00:00 [received]
PHST- 2020/08/26 00:00 [revised]
PHST- 2020/08/27 00:00 [accepted]
PHST- 2020/09/03 06:00 [entrez]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2021/02/24 06:00 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - ijms21176252 [pii]
AID - ijms-21-06252 [pii]
AID - 10.3390/ijms21176252 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Aug 29;21(17):6252. doi: 10.3390/ijms21176252.