PMID- 32875774
OWN - NLM
STAT- MEDLINE
DCOM- 20200903
LR  - 20200903
IS  - 1003-0034 (Print)
IS  - 1003-0034 (Linking)
VI  - 33
IP  - 8
DP  - 2020 Aug 25
TI  - [Research advances in pathomechanism and treatment of joint contracture].
PG  - 788-92
LID - 10.12200/j.issn.1003-0034.2020.08.020 [doi]
AB  - Joint contracture is one of the common musculoskeletal disorders. It has 
      seriously disturbed patients' activities of daily living in various aspects. The 
      pathogenesis of it is eager to explore to distinct degree. Nowadays the 
      thickeness and fibrosis of joint capsular is redarded as the major reason to 
      joint contracture. It is reported that excessive fibroblasts and myofibroblasts 
      activity, collagen hyperplasia, and extracellular matrix (ECM) deposition in 
      these fibrotic condtions lead to the contracture. In addition, upregulators of 
      myofibroblast and collagen synthesis, transforming growth factor-beta 1 (TGF-beta1), 
      and connective tissue growth factor (CTGF) were shown to be increased. Altered 
      levels of cytokines were also thought to play a role in this process as elevated 
      levelsof tumor necrosis factor-alpha(TNF-alpha), matrix metalloproteinases(MMPs) and 
      abnormal distribution tissue inhibitors of MMPs(TIMPs) were demonstrated in 
      contracted capsules. At present, the methods for clinical treatment of joint 
      contracture mainly include two major categories:stretching therapy, physical 
      factor therapy, exercise therapy, botulinum toxin injection and other 
      non-surgical treatments, arthroscopic lysis, open lysis, and other surgical 
      treatments. Surgical treatment is performed when non-surgical treatment is 
      difficult to achieve further improvement. It has a good effect on mild to 
      moderate joint contracture, but it is difficult to completely restore joint 
      activity for serious joint contracture. Although clinical treatment methods are 
      diverse, the clinical effects are staggered and the effectiveness of their 
      treatment is controversial. Joint contracture is an important challenge faced by 
      orthopedics and rehabilitation physicians, therapists and patients. The review 
      summarized the pathogenesisand treatment of joint contracture and provided a 
      theoretical basis for clinical diagnosis and treatment.
FAU - Wang, Lu
AU  - Wang L
AD  - Department of Rehabilitation Medicine, the first Medical Center of Chinese PLA 
      General Hospital, Beijing 100853, China.
FAU - Jia, Zi-Shan
AU  - Jia ZS
AD  - Department of Rehabilitation Medicine, the first Medical Center of Chinese PLA 
      General Hospital, Beijing 100853, China.
FAU - Zhang, Li-Ning
AU  - Zhang LN
AD  - Department of Rehabilitation Medicine, the first Medical Center of Chinese PLA 
      General Hospital, Beijing 100853, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Gu Shang
JT  - Zhongguo gu shang = China journal of orthopaedics and traumatology
JID - 9815790
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - *Activities of Daily Living
MH  - *Contracture
MH  - Fibroblasts
MH  - Fibrosis
MH  - Humans
MH  - Joint Capsule
MH  - Transforming Growth Factor beta1
OTO - NOTNLM
OT  - Contracture
OT  - Joint capsule
OT  - Myofibroblast
OT  - Stretch
EDAT- 2020/09/03 06:00
MHDA- 2020/09/04 06:00
CRDT- 2020/09/03 06:00
PHST- 2020/09/03 06:00 [entrez]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
AID - 10.12200/j.issn.1003-0034.2020.08.020 [doi]
PST - ppublish
SO  - Zhongguo Gu Shang. 2020 Aug 25;33(8):788-92. doi: 
      10.12200/j.issn.1003-0034.2020.08.020.