PMID- 32876755 OWN - NLM STAT- MEDLINE DCOM- 20210826 LR - 20220531 IS - 1615-6714 (Electronic) IS - 1434-5293 (Print) IS - 1434-5293 (Linking) VI - 82 IP - 5 DP - 2021 Sep TI - Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets. PG - 329-336 LID - 10.1007/s00056-020-00247-1 [doi] AB - PURPOSE: During orthodontic treatment with fixed appliances, demineralization around brackets often occurs. The aim of this in vitro study was to investigate the effect of the caries-protective self-assembling peptide P11‑4 (SAP P11-4) on the shear bond strength of metal brackets. METHODS: In all, 45 extracted human wisdom teeth were available for the study. The teeth were randomly divided into 3 groups (each n = 15) and pretreated as follows: test group 1: application of SAP P11‑4 (Curodont Repair, Windisch, Switzerland) and storage for 24 h in artificial saliva; test group 2: application of SAP P11‑4; control group: no pretreatment with SAP P11‑4. A conventional metal maxillary incisor bracket (Discovery, Dentaurum, Ispringen) was adhesively bonded to each buccal surface. The shear bond strength was tested according to DIN 13990. After shearing, the Adhesive Remnant Index (ARI) was determined microscopically (10 x magnification). Analysis of variance (ANOVA) was used to check the groups for significant differences (alpha = 0.05). The distribution of the ARI scores was determined with the chi (2) test. RESULTS: There was no significant difference in shear forces between the groups (p = 0.121): test group 1 = 17.0 +/- 4.51 MPa, test group 2 = 14.01 +/- 2.51 MPa, control group 15.54 +/- 4.34 MPa. The distribution of the ARI scores between the groups did not vary (p-values = 0.052-0.819). CONCLUSION: The application of the caries protective SAP P11‑4 before bonding of brackets did not affect the shear bond strength. Therefore, pretreatment of the enamel surface with SAP P11‑4 shortly before bracket insertion can be considered. CI - (c) 2020. The Author(s). FAU - Knaup, Thomas AU - Knaup T AD - Dental School, Dept. of Orthodontics, Philipps-University Marburg, Georg-Voigt Str. 3, 35039, Marburg, Germany. FAU - Korbmacher-Steiner, Heike AU - Korbmacher-Steiner H AD - Dental School, Dept. of Orthodontics, Philipps-University Marburg, Georg-Voigt Str. 3, 35039, Marburg, Germany. FAU - Jablonski-Momeni, Anahita AU - Jablonski-Momeni A AUID- ORCID: 0000-0001-5763-7924 AD - Dental School, Dept. of Orthodontics, Philipps-University Marburg, Georg-Voigt Str. 3, 35039, Marburg, Germany. momeni@staff.uni-marburg.de. LA - eng PT - Journal Article PT - Randomized Controlled Trial TT - Der Einfluss des kariesprotektiven Peptids P11-4 auf den Haftverbund zwischen Metallbracket und Zahnschmelz. DEP - 20200902 PL - Germany TA - J Orofac Orthop JT - Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie JID - 9713484 RN - 0 (Peptides) RN - 0 (Resin Cements) SB - IM EIN - J Orofac Orthop. 2021 May 21;:. PMID: 34021382 MH - *Dental Bonding MH - Dental Caries Susceptibility MH - Dental Stress Analysis MH - Humans MH - Materials Testing MH - *Orthodontic Brackets MH - Peptides MH - Resin Cements MH - Shear Strength MH - Stress, Mechanical MH - Surface Properties PMC - PMC8384806 OTO - NOTNLM OT - Dental caries, prevention OT - Dental enamel OT - Dental white spots OT - Oral hygiene OT - Orthodontic appliances, fixed COIS- T. Knaup, H. Korbmacher-Steiner and A. Jablonski-Momeni declare that they have no competing interests. EDAT- 2020/09/03 06:00 MHDA- 2021/08/27 06:00 PMCR- 2020/09/02 CRDT- 2020/09/03 06:00 PHST- 2020/01/28 00:00 [received] PHST- 2020/06/21 00:00 [accepted] PHST- 2020/09/03 06:00 [pubmed] PHST- 2021/08/27 06:00 [medline] PHST- 2020/09/03 06:00 [entrez] PHST- 2020/09/02 00:00 [pmc-release] AID - 10.1007/s00056-020-00247-1 [pii] AID - 247 [pii] AID - 10.1007/s00056-020-00247-1 [doi] PST - ppublish SO - J Orofac Orthop. 2021 Sep;82(5):329-336. doi: 10.1007/s00056-020-00247-1. Epub 2020 Sep 2.