PMID- 32876991
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 44
IP  - 12
DP  - 2020 Dec
TI  - The protective effects of umbilical cord-derived endothelial colony forming cells 
      on hepatic veno-occlusive disease.
PG  - 2541-2552
LID - 10.1002/cbin.11461 [doi]
AB  - Hepatic veno-occlusive disease (HVOD) characterized by endothelial cell 
      dysfunction is one of the serious complications after hematopoietic stem-cell 
      transplantation or chemotherapeutic drug application. The mortality of HVOD 
      patients with multiorgan dysfunction is as high as 80%. The primary aim of this 
      study was to evaluate whether the infusion of human umbilical cord-derived 
      endothelial colony forming cells (hUC-ECFCs) could mitigate HVOD injury and 
      investigate the underlying mechanism. We found that the expression of chemokine 
      C-X-C chemokine ligand 12 (CXCL12) was markedly increased in the livers of HVOD 
      mice. Meanwhile, hUC-ECFCs infusion could significantly ameliorate liver injury 
      in HVOD mice, which was accompanied by hUC-ECFCs recruitment in the liver, 
      reduced liver pathological alterations, and decreased serum alanine 
      aminotransferase and aspartate aminotransferase activity. Besides, CXCL12-induced 
      migration in hUC-ECFCs was partly impeded by chemokine receptor type 7 (CXCR7) 
      silence or CXCR4 blockage. In conclusion, our results demonstrated that hUC-ECFCs 
      could mitigate HVOD through homing to the injured liver via the 
      CXCL12-CXCR4/CXCR7 signaling pathway.
CI  - (c) 2020 International Federation for Cell Biology.
FAU - Chen, Lulu
AU  - Chen L
AD  - Department of Clinical Medicine, Graduate School, Jining Medical University, 
      Jining, Shandong, China.
AD  - Department of Hematology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
AD  - Institute of Blood and Marrow Transplantation, Jining Medical University, Jining, 
      Shandong, China.
FAU - Zhang, Jingjing
AU  - Zhang J
AD  - Department of Hematology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
AD  - Institute of Blood and Marrow Transplantation, Jining Medical University, Jining, 
      Shandong, China.
FAU - Liu, Xin
AU  - Liu X
AD  - Department of Clinical Medicine, Graduate School, Jining Medical University, 
      Jining, Shandong, China.
AD  - Department of Hematology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
AD  - Institute of Blood and Marrow Transplantation, Jining Medical University, Jining, 
      Shandong, China.
FAU - Yao, Mingkang
AU  - Yao M
AD  - Department of Clinical Medicine, Graduate School, Jining Medical University, 
      Jining, Shandong, China.
AD  - Department of Hematology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
AD  - Institute of Blood and Marrow Transplantation, Jining Medical University, Jining, 
      Shandong, China.
FAU - Zhang, Hao
AU  - Zhang H
AUID- ORCID: 0000-0002-1925-6618
AD  - Department of Clinical Medicine, Graduate School, Jining Medical University, 
      Jining, Shandong, China.
AD  - Department of Hematology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
AD  - Institute of Blood and Marrow Transplantation, Jining Medical University, Jining, 
      Shandong, China.
LA  - eng
GR  - ZR2017LH029/Natural Science Foundation of Shandong Province/
GR  - 2017WS514/Medicine and Health Science Technology Development Program of Shandong 
      Province/
GR  - JY2017FS008/Scientific Research Supported Foundation for Young Teacher of Jining 
      Medical University/
GR  - 2016-BS-001/Doctoral Research Foundation of Affiliated Hospital of Jining Medical 
      University/
GR  - MP-2016-007/Project of Scientific Research Program of Affiliated Hospital of 
      Jining Medical University/
PT  - Journal Article
DEP - 20200928
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (CXCR4 protein, mouse)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Cmkor1 protein, mouse)
RN  - 0 (Receptors, CXCR)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Animals
MH  - Cell Movement/drug effects
MH  - Cells, Cultured
MH  - Chemical and Drug Induced Liver Injury/prevention & control
MH  - Chemokine CXCL12/metabolism
MH  - China
MH  - Endothelial Cells/metabolism
MH  - Hepatic Veno-Occlusive Disease/metabolism/pathology/*therapy
MH  - Human Umbilical Vein Endothelial Cells/*metabolism/physiology
MH  - Humans
MH  - Liver/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Receptors, CXCR/metabolism
MH  - Receptors, CXCR4/metabolism
MH  - Umbilical Cord/cytology
OTO - NOTNLM
OT  - cell adhesion
OT  - cytokines/interleukins
EDAT- 2020/09/03 06:00
MHDA- 2021/07/10 06:00
CRDT- 2020/09/03 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/08/28 00:00 [revised]
PHST- 2020/08/30 00:00 [accepted]
PHST- 2020/09/03 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/09/03 06:00 [entrez]
AID - 10.1002/cbin.11461 [doi]
PST - ppublish
SO  - Cell Biol Int. 2020 Dec;44(12):2541-2552. doi: 10.1002/cbin.11461. Epub 2020 Sep 
      28.